PubMed Health⌕ Search

Biomedical subjects

E F Dempsey

Publications and source records attributed to E F Dempsey.

8 recordsLinked to original sources
PubMed1988

Skeletal muscle pathology in ovine congenital progressive muscular dystrophy. 1. Histopathology and histochemistry.

The histopathological lesions of ovine congenital progressive muscular dystrophy (CPMD) were characterized by myofiber hypertrophy, focal myofibrillar degeneration, formation of peripheral and central sarcoplasmic masses devoid of myofibrils and internal nuclei often in chains. Progressive loss of myofibrils was associated with atrophy of the fiber and eventual collapse of the sarcolemma. The process was polyphasic, consequently in mature lesions there was great variation in fiber diameter. Split fibers were common but ring fibers occurred rarely. Myofiber loss was associated with fatty or fibrous tissue replacement. Only type I (red, slow twitch, oxidative) fibers were affected and there was no histological evidence of effective regeneration. Ovine CPMD has many histopathological features in common with dystrophia myotonica in humans.

Adenosine Triphosphatases↗
PubMed1988

Skeletal muscle pathology in ovine congenital progressive muscular dystrophy. 2. Myofiber morphometry.

Fiber-type proportions were determined in 12 skeletal muscles (peronaeus tertius, tibialis cranialis, tensor fascia lata, psoas major, extensor digitorum lateralis, tensor fascia antibrachii, vastus intermedius, soleus, anconaeus, and flexor digitorum superficialis of fore and hind limb) from infantile (20 weeks), juvenile (16 months) and adult (2.5 and 3.5 years) Merino sheep with ovine congenital progressive muscular dystrophy and in age-matched controls. Although confined to type I fibers, lesions were severe not only in type I fiber dominant muscles (vastus intermedius, soleus and anconaeus) but also in the type II dominant medial triceps brachii and in the superficial digital flexors which had approximately equal proportions of both fiber types. The frequency distribution curves of myofiber diameter in dystrophic anconaeus and superficial digital flexor of the fore limb altered as the disease progressed. In young sheep (20 weeks) type I fibers increased in size, then in juvenile and adult sheep the curves became flatter and broader and lost symmetry due to the presence of hypertrophic and atrophic fibers. The fiber diameter profiles were similar to those seen in Duchenne dystrophy in humans.

Animals↗
PubMed1984

Abdominal aortic aneurysms: Rotorua 1972-1982.

The experience of abdominal aortic aneurysms in Rotorua Hospital from 1972 to 1982 is analysed. During this time sixteen abdominal aortic aneurysms were resected. Thirteen were acute operations for leaking aneurysms and three were elective operations. Among the thirteen acute cases, preoperatively four were in shock and three of these died. There was one peri-operative death among the nine unshocked but acute aneurysms.

Aged↗
PubMed1981

Hydatid disease at a peripheral hospital: a review of 25 years' experience.

A review of all patients presenting to Rotorua Hospital over a 25 year period with a diagnosis of hydatid disease was undertaken. The type of presentation, symptoms, signs, and results of investigations were all recorded. Where patients were submitted to surgery, the nature of the procedure and the postoperative course were noted. Mortality, and the presence or absence of recurrent disease at follow up was noted. Thirty-six patients were thus reviewed and the male to female ratio was 24:12. Twenty-nine of the patients were Maori and seven were European. Twenty-one of the patients (58 percent) had liver cysts alone, and 12 of the patients presented acutely. All but six of the patients underwent surgery at rotorua Hospital with a wide variation in the nature of the operative procedures. The overall mortality from hydatid disease was 11 percent and over a mean period of 8.9 years, of the 25 patients available for follow up, 22 remained free of the disease.

Acute Disease↗
PubMed1977

Seat belt injury of the colon.

Two cases of seat belt injury of the colon are presented. In each case a gangrenous tube of mucosa remained while the muscle layers and adjacent mesentery were divided. The delay before the severity of the injury is appreciated is emphasised.

Colon↗