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Biomedical subjects

E F Gauron

Publications and source records attributed to E F Gauron.

At least 19 recordsLinked to original sources

Long-term follow-up of patients with chronic back pain treated in a multidisciplinary rehabilitation program.

STUDY DESIGN: The study evaluated the long-term outcomes of 129 chronic low back pain patients who had completed a multidisciplinary rehabilitation program. OBJECTIVES: Two major outcome issues were addressed--one related to the effectiveness of the program as measured by return to work, use of the medical system, and sense of well being, and the other concerning the stability of the outcome effect over time. SUMMARY OF BACKGROUND DATA: Other outcome studies have established the short-term effectiveness of rehabilitation programs such as the present one with between 50% and 75% of patients. However, long-term follow-up--i.e., 1 1/2 to 2 years or more--has been lacking to determine what happens later. METHODS: Graduates of the program were contacted by telephone to complete a 23-item questionnaire. Every effort was made to include all who had completed the program. Many had moved away or were inaccessible, but few of those contacted refused to participate. RESULTS: An attempt was made to classify the job outcome into good, fair, and poor outcomes by weighting return to work, remaining at work, and continuing to look for work. Forty-nine percent of the sample attained a good job outcome, 13% a fair job outcome, and 38% a poor job outcome. Regarding general well-being, 53% reported doing better or much better, 27% reported being about the same, and 20% reported being worse or much worse at follow-up. CONCLUSIONS: The results provide support for the efficacy of programs such as this.

Adult↗

The art of cognitive self-regulation.

We like to think our minds were created to serve as truth-finding instruments, but it is difficult to imagine a mechanism that could do a worse job of straight thinking, and yet give the illusion of doing a first-class job. This article presents an instructional format to promote increased rationality of thinking as well as greater cognitive flexibility and cognitive self-regulation.

Adaptation, Psychological↗

Effects of chronic administration of diphenylhydantoin on learning and offspring behavior.

An original parent group of 72 Sprague-Dawley albino rats was subdivided into four treatment groups that were administered 5, 10 or 15 mg/kg diphenylhydantoin and distilled water on days 5 to 55 after birth. At 85 days of age the drug females were bred to naive males to produce an F1 generation. In similar fashion, the F1 females were bred at maturity to produce and F2 generation. Neither offspring group received any drug administrations or experimental treatments. All three groups were tested on avoidance conditioning at 75 days of age for a total of 150 trials. The results of statistical analysis indicated no significant differences in number of correct responses in the parent group, a significant Drug effect in the offspring groups and a significant Dose effect in the F2 generation. This detrimental cross-generational effect on avoidance conditioning, caused by chronic diphenylhydantoin administration, is consistent with previously noted cross-generational effects of trifluoperazine, chlorpromazine, and methylphenidate.

Animals↗

Effects of methylphenidate on avoidance learning in the aged rat.

Twenty Sprague Dawley rats, aged 22 to 26 months were given subcutaneous injections of 4.5 mg/kg methylphenidate or distilled water. Twelve minutes after the single injection was given, rats began 90 trials of avoidance conditioning. Drug animals made significantly more correct responses than did the control animals. tresults indicate that use of methylphenidate in aged rats improved avoidance learning.

Aging↗

Chronic methylphenidate effects on learning in an F2 generation.

This study investigated chronic methylphenidate effects on the learning of undrugged second generation offspring. Seventy-two albino rats were tested on avoidance conditioning. The results indicated that (a) the learning of the undrugged offspring was affected, (b) differential sex effects were obtained, and (c) some difficulty was encountered in reproduction.

Animals↗

Methylphenidate effects on avoidance learning at two ages in the rat.

The major purpose of this investigation was to assess the effects of methylphenidate on avoidance learning at two ages. The subjects were 96 naive albino rats, equally divided between the sexes. One-half received daily drug administrations beginning at 47 days of age; one-half began at 87 days of age. Both groups were divided into three drug dosage levels (0.5, 1.5 and 4.5 mg/kg) and a distilled water control group. Methylphenidate was administered s.c. for a total of 18 days. Following 3 days of drug administrations only, 10 daily trials on avoidance conditioning were administered approximately 10 min after drugging to a total of 150 trials. The major findings indicated that: (1) no significant difference in avoidance response acquisition was obtained in the comparison between drug and control groups, (2) a dose effect was obtained in that the M4.5 group made siginificantly more correct responses than the M1.5 group, and (3) animals drugged beginning at 87 days made significantly more correct responses than those drugged beginning at 47 days.

Aging↗