[Recruiting of Norwegian physicians in the 19th century].
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History, 19th Century↗
Biomedical subjects
E F Hjort
Publications and source records attributed to E F Hjort.
Continued experimental study of the pathogenesis of sporadic bacteriuria in the rat. III.
With reference to a previously published experimental model, the author relates continued experiments with sporadic, experimental hydronephrosis. The experimental animals were as previously, white female rats. The results confirmed the author's assertion that sporadic infection of an experimental hydronephrosis occurs under conditions where ascending infection of the urinary tract is precluded. In these experiments, age and environment of the animals did not influence sporadic infection. In experimental, intravenously induced Escherichia coli bacteremia, however, old age seemed to increase the frequency in the experimental model.
Age Factors↗
Continued experimental study on the pathogenesis of sporadic bacteriuria in the rat. II.
The previously described experimental model implying ligature of the left ureter in the rat has been used in continued experiments. The present experiments intended to saturate the reticuloendothelial system with dead E. coli, and thereby produce a possible increase in the seeding of bacteria into the experimental locus minoris resistentiae. The results indicate that usage of organic material as E. coli may also stimulate the RES system. Most probably, the incidence of experimental infections in the left ureter is influenced upon by 2 main variables: the size of the experimental bacteremia and the current state of host defence mechanisms.
Animals↗
[Vis medicatrix naturea and the surgery breakthrough in Norway].
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General Surgery↗
Continued experimental study on the pathogenesis of sporadic bacteriuria in the rat.
An experimental model implying ligature of the left ureter in the rat has previously (1977) been described by the author. The same model has been used in the experiments which are presented in this paper. The aim has been to study further the hematogenous seeding of bacteria to the hydronephrotic left kidney. The experiments seem to confirm the author's view that sporadic hematogenous infection with intestinal bacteria occasionally takes place and can be demonstrated by this method. Intravenous injection of E. coli showed that the minimal kidney infecting dose amounted to 0.5 ml E. coli 10(6) bacteria per ml. The author found considerable increase of sporadic infection after splenectomy and partial liver resection.
Animals↗
Experimental hydronephrosis. Influence of infection on the histological picture.
The present paper is concerned with a histological examination of 110 pairs of rat kidneys from an experimental investigation on unilateral hydronephrosis previously published. Urine sampled by puncture of the obstructed pelvis remained sterile in cultures from most of the cases, though in 22 of a total of 184 cases growth of bacteria occurred. Intravenous injection of E. coli resulted in substantial growth of the bacteria in similar samples. In 2 cases the untreated control kidney displayed histological evidence of infection. The histology indicated that damage to the renal parenchyma in hydronephrotic kidneys probably predisposes the kidney for hematogenous infection.
Animals↗
An experimental study on the pathogenesis of sporadic bacteriuria in the rat.
An experimental model is used in which one ureter of a rat is ligated with the object of forming a hydronephrosis from which urine specimens can subsequently be collected. Ascending urinary infection from the bladder is excluded by the ligation. The investigations with this experimental model showed that growth of intestinal bacteria occasionally occurred in culture of urine obtained from the occluded renal pelvis. Ascending infection being excluded, these bacteria had in all probability entered the renal pelvis via the hydronephrotic kidney. The frequency of infection seemed to increase with age. Whedronephrotic kidney. The frequency of infection seemed to increase with age. When intravenous injection of E. coli was added to the standard experiment, substantial growth of these bacteria was found in the left upper urinary tract in 16 out of 17 animals thus treated.
Animals↗
Partial resection of the renal pelvis and lower pole of the kidney for hydronephrosis.
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Adolescent↗
[Course in urology].
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Education, Medical, Continuing↗