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Biomedical subjects

E F Onishchenko

Publications and source records attributed to E F Onishchenko.

12 recordsLinked to original sources

[The potentials of echocardiography in the diagnosis of interatrial communications and in the determination of surgical treatment indices].

The authors have examined 550 patients (210 men and 340 women) with the suspected diagnosis of interatrial communication. The age of the patients was from 4 to 53 years (80% of the patients were 10-20 years of age). An original method of prolonged infusion contrast echocardiography and catheterization of the heart were used in 186 patients. Respiration tests were performed in 88 of them. A great defect of the interatrial septum (DIAS) was diagnosed in 31 patients, 15 patients had small DIAS, 40 patients had potent foramen ovale, 464 patients had functional noise. The prolonged infusion contrast echocardiography allowed the right-left shunt to be detected in all the patients with great DIAS, in 86.7% of the patients with small DIAS and in 87.5% of the patients having potent foramen ovale (false positive result was noted only in 2% of the patients with functional noise). The respiration test in patients with functional noise was (21.4 +/- 4)%, with foramen ovale (20 +/- 8)%, with small DIAS (17 +/- 6)% and with great DIAS (8.3 +/- 3)%. The prolonged infusion contrast echocardiography and the respiration test are though by the authors to be indicated to all patients with the suspected diagnosis of the interatrial communication. They allow making the exact diagnosis, estimating the degree of hemodynamic disturbances and determining indications to surgical treatment.

Adolescent↗

[Heart murmurs associated with organic murmurs].

157 patients with congenital heart disease were examined clinically and echocardiographically. Patients with interventricular septal defect, interatrial septal defect or patent ductus arteriosus having typical organic murmur exhibited atypical sound oscillations forming concording epicenter (42.3% of patients). It is believed that all patients with congenital heart disease have additional morphofunctional peculiarities of intracardiac structures. It is thought that these are associated factors forming cardiac murmurs and residual murmurs after the disease correction.

Adolescent↗

[Prolonged contrast infusion echocardiography with hydrogen peroxide].

A new method of prolonged C-echo-CG with HP implies intravenous administration of 0.3% HP solution for continuous contrasting of right heart chambers for 5-20 minutes. A new technique of C-echo-CG was introduced in 277 patients with innocent cardiac murmur (93), interventricular septal defects (19), interatrial septal defects (26), open oval foramen (42), tricuspid regurgitation (56), pulmonary artery regurgitation (41). Prolonged C-echo-CG with HP was combined with respiratory stress tests. The technique is simple, more effective than short-term C-echo-CG, free of severe side effects and complications.

Adolescent↗

[The "flickering" phenomenon in the right atrium].

To specify characteristics and reasons of flickering in the right auricle (FRA) detected at two-dimensional ECG, 278 patients with innocent cardiac murmur (ICM) and 93 patients with congenital heart disease (CHD) underwent clinical and ECG examinations. FRA was found in 34.5% of ICM and 57.0% of CHD patients. Topographic-anatomical, ECG, intraoperative comparative investigations suggested that FRA may result from the eustachian valve movements and fenestration-filament structure of the endocardium at the opening of the inferior vena cava, interatrial septum, coronary sinus valve, base of the atrioventricular cusps. The movement of the eustachian valve was followed through the cardiac cycle. It is thought advisable that FRA characteristics should be taken into consideration for valid understanding of right atrial circulation in normal and CHD conditions.

Adult↗

["Innocent" heart murmurs].

The paper presents the review of the literature data and the results of the authors' own experience in the aspects of the origin and clinical interpretation of "innocent" cardiac murmurs (ICM). It was suggested that ICM were a regular phenomenon in the majority of the young people. Contradictions in current views on the problem of ICM appearance were discussed from the point of view of the leading importance of disproportion in the development of the major vessels and cardiac cavities, systolic regurgitation at atrioventricular valvular dysfunction, hyperkinetic cardiac effects. The paper presents the data which permit one to consider morphofunctional features of intracardiac structures violating the uniformity and equality in the cardiac release tracts as leading causes of ICM appearance. Pathogenetic unity of ICM and organic murmurs was distinguished as the manifestation of murmuring turbulent flows. Principle difference between the leading mechanisms of these murmurs occurrence was discussed as well.

Adolescent↗

[The significance of the chordal apparatus of the heart in forming "innocent" murmurs (clinical echocardiographic research)].

Clinical and echocardiographic studies were carried out in 100 young men (mean age 18.0 +/- 3.0 years) with "harmless" murmur (HM). 20 young men (mean age 17.0 +/- 2.0 years) were examined as control. In these men, murmur could not be detected both at rest and after 15 squattings and the hyperventilation test. No relationship was discovered between the murmur intensity and gravity of heart hyperdynamia, although in persons with HM, the predominance of hyperdynamia could be observed. It is believed that the intensity of HM is due to the morphofunctional features of the cardiac structures. The chordal apparatus of the heart is viewed as one of them. In 37% of persons with HM, echocardiography revealed a phenomenon of the "fluttering" chorda, which lies in diastolic-systolic hypermobility of one of the commonly attached chordae of the mitral valve because of its excessive length and weak tonic tension. That phenomenon is usually associated with so-called Steele's murmur. It is concluded that via the phenomenon of the "fluttering" of the chorda of the mitral valve there may occur labile and, in some cases, of "musical" non-regurgitation systolic murmur in local dysfunction of the papillary muscles.

Adolescent↗

[Characteristics of cardiac structure and function in young persons with so-called functional murmurs (clinical echocardiographic research)].

As many as 70 males aged 14 to 28 years with functional systolic murmur and 16 young persons of the same age, in whom murmur failed to be detected both at rest and after 15 squattings and the hyperventilation test. It was shown by echocardiography that in addition to the proneness to the hyperdynamic type hemodynamics, the patients with functional murmurs manifested, in different anatomicofunctional heart zones, definite characteristics of the heart structure which in the majority of the examined (77.1%) were marked by deformity of the left ventricular contours. Therefore, the left ventricular chamber is the main area where in young persons there occurs functional systolic murmur. Frequent combination with each other of heart structure characteristics in persons with functional systolic murmur attests to the diversity of the causes and mechanisms by which it forms.

Adolescent↗

[The mitral valve chordal system as a cause of innocuous heart murmur].

To specify the role of morphofunctional features of mitral chorda in forming innocent cardiac murmur (ICM), 107 and 20 young men with or without ICM, respectively, were examined clinically and instrumentally at rest, muscular load and hyperventilation. Echocardiography was recorded in one-dimentional, sectoral and Doppler regimens. Fluttering chorda (FC) of the mitral valve (MV) manifesting by hyperkinesia of usually fixed MV chorda, its early systolic dislocation into the left ventricular outflow tract was registered in 34.5% of ICM patients, 11.2% of them had echocardiographic evidence of the chordal shift in the systole into the above tract. In ICM-free subjects the phenomenon FC and the systolic chordal shift were absent (the difference was significant, p < 0.05). The FC phenomenon is attributed to local dysfunction of the papillary muscles and may produce distinct labile nonregurgitation systolic murmur.

Adolescent↗

[Possibilities of radiodiagnosis in systemic connective tissue syndromes].

Two cases with a rare systemic disease are described. The first of them is as follows: a female aged 58 developed sclerodermic cardiomyopathy manifesting by cardiomegaly which resulted in myocardial infarction followed by heart aneurysm. In the second observation a female aged 60 developed mixed systemic connective-tissue Sharp-type syndrome though with calcinosis in heart structures (similarly as in Thibierge - Weissenbach syndrome) and with renal cysts, possibly of a connective-tissue origin. In this latter case the role of ultrasonic examinations in the detection of heart and kidney involvement was of particular importance. In both cases glucocorticoids were found diagnostically valuable for the detection of autoimmune pathologic processes.

Diagnosis, Differential↗