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Biomedical subjects

E Farthmann

Publications and source records attributed to E Farthmann.

At least 37 records · Page 2Linked to original sources

[Study on the protective effect of vitamin A on stress ulcer of the rat (author's transl)].

The protective effect of vitamin A on "restraint stress" ulcer formation was studied in rats. Animals receiving i.m. injections of 1000 or 2000 IU vitamin A, respectively, every 6 h after 19 h of immobilisation had significantly fewer and smaller ulcers than had the controls. There was no difference between the 2 doses. Only a few rats had no gastric ulcers at all, that means the protection was not absolute. Therapeutic use of vitamin A in the prophylaxis of stress ulcer is discussed.

Animals↗

[Duodenal reflux and gastritis after Billroth I gastric resection (author's transl)].

Endoscopic and biopsy studies were undertaken in 92 patients who had undergone partial gastric resection (end-to-end gastroduodenostomy, Billroth I) one to seven years previously. In addition, the amound of duodeno-gastric reflux was evaluated by measuring bromsulphalein excretion in gastric juice. Atrophic gastritis occurred in 36%, while superficial gastritis was noted in 49% of patients. The degree and severity of the inflammatory changes was most marked near the anastomosis. The severity of the duodenal gastric reflux was decisive in the development of the atrophic mucosal changes. There was no demonstrable relationship between the degree of mucosal changes and the interval since the operation.

Atrophy↗

[Esophagojejunostomy anastomosis technique (author's transl)].

To overcome the specific problems of esophagojejunostomy, leakage and reflux, a method of end-to-side anastomosis completely surrounded by the proximal jejunal stump was developed. A proximal jejunal loop is isolated and used for isoperistaltic interposition between esophagus and duodenum. About 15 cm of the jejunal segment are left orally to the proximal anastomosis which is performed end-to-side using a single layer of interrupted sutures. The blind loop is then wrapped completely and symmetrically around the anastomosis and sutured to itself and the esophagus to keep it in place. Complete envelopment of the leakage-prone anastomosis is thus achieved. The distal end of the jejunal segment is anastomosed to the duodenum end-to-end. The technique in addition provides protection against reflux into the esophagus by gaseous distension of the proximal jejunal segment surrounding the anastomosis without impeding the passage due to a valve-like action which allows unidirectional flow. Clinical results so far are promising and show absence of leakage and/or stenosis in all cases of esophagojejunostomy operated according to the method described.

Esophagoplasty↗

[Splenic artery ligature and latero-lateral anastomosis in portal hypertension (author's transl)].

A new type of shunt for decompressing portal hypertension is described, consisting of ligation of the spleno-renal anastomosis. This reduces the pressure in the portal territory and in the dangerous gastric and oesophageal varices. In addition the procedure also abolishes the marrow inhibition due to splenic activity without removing the spleen and maintaining part of the portal circulation. The advantages and disadvantages of various decompression operations are discussed and compared with other methods in current use.

Arteriovenous Shunt, Surgical↗

[Nitrogen balance in routine surgical interventions with the use of Vivasorb].

With Vivasorb, the surgical patient's full alimentation can be maintained up to a few hours before the operation. In the postoperative phase, the nitrogen balance of patients having undergone minor surgical intervention and in a state of moderate catabolism can be kept under control in a slightly negative range by the exclusive administration of Vivasorb. In patients with more severe catabolism, the oral supply of Vivasorb cannot fully replace parenteral nutrition, it can, however, support it.

Diet↗