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Biomedical subjects

E Fellinger

Publications and source records attributed to E Fellinger.

27 records · Page 2Linked to original sources
PubMed1985

[A possibility of cutting frozen sections of bone tissue in routine pathology].

A low priced, efficient frozen section cutting device is described to produce 5 microns sections of frozen undecalcified bone specimen blocks in routine pathology. The device was developed by combining two commercially-available instruments, namely a frozen section microtome with methyl alcohol cooling and a hard tissue microtome. Bore holes were drilled in the hard tissue knife to permit cooling, using the methyl alcohol system of the other microtome.

Bone Neoplasms↗
PubMed1980

Effect of electrical stimulation of the neurohypophysis on ACTH release in rats with hypothalamic lesions.

Electrical stimulation of the neural lobe (NL) of the pituitary induces a rise in plasma corticosterone indicating the release of adrenocorticotropin (ACTH) in rats pretreated with dexamethasone, morphine and pentobarbitone. 7-8 days after placing an anterolateral cut around the medial basal hypothalamus (MBH), the rats failed to respond with ACTH release to electrical stimulation of the NL; the number of nerve fibers and terminals in the NL decreased to less than 5% of the normal; and ACTH releasing activity of acid extracts of the NL was undetectable using both in vivo and in vitro tests, which are insensitive to vasopressin. After lesions of the paraventricular nuclei the stimulation of the NL elecited a rise of plasma corticosterone that was significantly less than that in the controls. These results suggest that the NL of the pituitary contains electrically excitable fibers capable of releasing corticotropin-releasing factor (CRF; distinct from vasopressin) and that these fibers probably originate from outside the MBH, with a portion of them coming from or through the paraventricular nuclei or their immediate vincinity.

Adrenocorticotropic Hormone↗
PubMed1977

Ultrastructure of lymphatic capillaries in the human dental pulp.

Occlusal intradentinal cavities, prepared in normal human premolars and third molars to be extracted for orthodontic reasons, were filled for 7 to 11 days with gutta percha. A superficial pulpitis with localized small abscesses developed in the pulp chamber. Under local anesthesia, 0.2 to 0.3 cc of sterile colloidal carbon was injected in the pulp horn and the teeth were extracted 1 to 3 h later. Lymphatic capillaries could thus be identified in the pulpal tissues. They were characterized by a thin endothelium with occasional large intercellular clefts, absence or incompleteness of basement membrane, absence of pericytes, absence of luminal red blood cells, and presence of a filamentous material between the endothelium and the surrounding collagen fibrils. Moreover, some structural variations were observed.

Adolescent↗
PubMed1976

[Ultrastructure of the alveolodental ligament of the rat].

The ultrastructural study of periodontal ligaments of adult rat molars showed that the predominant cellular element consisted of fibroblasts and fibrocytes. These cells were responsible for the elaboration of the collagen precursors and for their destruction as was demonstrated by the presence of ellipsoidal intracytoplasmic vacuoles containing collagen. The abundance of microfilaments and microtubules as well as the presence of intermediary and tight junctions and nexus between the cell processes seemed to indicate that these cells are contractile and motile. Other cell types were intrequent. The ligament presented a high density of collagen fibrils grouped in bundles. Oxytalan fibrils were also observed. The blood capillaries showed mainly a continuous endothelium. Numerous myelinated and non-myelinated nerve fibrils, as well as nerve endings and mechano-receptors were identified.

Animals↗
PubMedDate not supplied

[Results of treatment of primary exclusively pulmonary metastatic Ewing sarcoma. A retrospective analysis of 41 patients].

41 patients presenting with primary metastatic Ewing's sarcoma or malignant peripheral neuroectodermal tumor (PNET) with initial metastases restricted to the lungs and/or pleural space were analysed with respect to clinical manifestation and treatment results retrospectively. All patients were treated according to the protocols CESS 81 and CESS 86 of the German Society of Pediatric Oncology and Hematology (GPOH). The time since diagnosis ranges from 19 to 137 months, with a median of 72 months. Median relapse-free survival time was 21.8 months. 18 patients were female, 23 were male. The majority of primary tumors exceeded 100 ml of volume. Preferred sites were the pelvis with 16 cases, the limbs with 14 cases and the chest wall with 6 cases. The histological specification of the tumor was Ewing's sarcoma in 22 and PNET in 11 patients, in 8 cases no specific distinction was given. As to local therapy of the primary tumor, 12 patients underwent radiotherapy, 11 surgery, and 18 a combination of both. Patients were allocated to one of these three options on an individual basis. Cytostatic drug treatment was given according to the GPOH-CESS 81 and CESS 86 protocols. As calculated by means of the Kaplan-Meier analysis, relapse-free survival was 30% ten years after diagnosis. Surgery or pulmonary irradiation of 12-20 Gy was applied to lung metastases. 12 of 27 patients are in continuous complete remission following this therapeutic approach.

Adolescent↗
PubMedDate not supplied

[Results following spongiosa transplantation in giant cell tumor of bone].

Between 1952-1988 47 giant cell tumors of the bone were treated at the Orthopedic University Clinic of Vienna with different surgical margins: In 9 cases a radical or wide, in 3 cases a marginal and in 35 cases an intralesional resection was performed. In the cases with intralesional resections the tumors were diligently curatted and the resulting bone cavity was shaved with a rase. In addition in eleven cases a chemical cauterization was done with phenol. Afterwards the lesion was filled up with autogenous or homogeneous bone chips with or without fibrin tissucol. In the cases where phenol was used no local recurrence was observed over a mean period of 39 months (max. 91, min. 6) of follow up. Because of the subchondral joint location of the giant cell tumors of the extremities a radical or wide resection usually causes the loss of a part of the joint which is followed by poor functional results. Intralesional resections in combination with phenol cauterization not only achieved good functional results, but also succeeded in reducing the rate of local recurrencies from 25-44% in 0 as described by other authors.

Adolescent↗
PubMedDate not supplied

[Intraoperative fatal fat and bone marrow embolism of the lung in implantation of a hip endoprosthesis with polymethylmethacrylate bone cement].

We report on an intraoperative lethal fat embolism and bone marrow embolism of the lung caused by implantation of hip endoprosthesis using acrylic bone cement. Autopsy revealed massive fat embolism of the lung and multiple bone marrow emboli within branches of the pulmonary arteries. It is concluded that there is a close relationship between implantation of hip endoprosthesis and death because fat embolism and bone marrow embolism was the only available evidence on post mortem examination.

Aged↗