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Biomedical subjects

E Ferrario

Publications and source records attributed to E Ferrario.

7 recordsLinked to original sources
PubMed1979

[Changes in the acid-base and water-electrolyte balance induced by salbutamol. "In vivo" studies in patients with chronic broncho-pulmonary disease and "in vitro" by tonometry of venous blood].

The Authors studied the effects of e.v. Salbutamol evaluating the acute "in vivo" variations of acid-base and hydro-electrolitic balance in 16 chronic obstructive lung patients undergoing e.v. drug administration, and also ionic variations "in vitro" of venous blood samples incubated and tonometrated with the drug. The results "in vivo" do not show variations of acid-base equilibrium (paO2, paCO2, pH, HCO3-); whereas diminution of haematocrit (Ht), rise of urinary osmolarity and variations of hydro-electrolitic balance (Na+, K+, Cl-) are demonstrated. The results "in vitro" do not show considerable variations on ionic assessment. These data, according to the other latest result, indicate the possible role of haemodilution. We think that the explanation of these phenomena could be a modification of renal water and electrolytes reabsorption, likely under the influence of antidiuretic hormone (ADH), stimulated in the hypothalamus and activated also by the beta-stimulant drug at tubular cell receptors.

Acid-Base Equilibrium↗
PubMed1979

[Plasma ion changes in venous blood incubated with beta receptor blockers and subjected to tonometry in vitro. 1. Study using propranolol].

The Authors considered the variations in electrolyte plasmatic assessment in blood samples incubated "in vitro" with propranolol (48 gamma/10 cc) and part of sample incubated with propranolol and theophyllin-ethilandiamin. The evaluation of electrolyte assessment was performed at 20'-40'-60' after tonometration. Sodium and potassium values increase in the samples with the beta-blocking agent and are statistically significant only after 20'; in further controls the increasing values persist. Chloride rises too, marked by a low statistic significance. No variations were observed in samples incubated also with propranolol and antiphosphodiestherasic agent. The Authors suggest trat data should confirm ionic transport blockage across the red cell membrane obtained with theophylline.

Biological Transport↗
PubMed1979

[Physiopathological and clinical data on post-hypercapnic metabolic alkalosis. A case of severe hypercapnia treated with drugs and in an "iron lung"].

The Authors produce a further contribution on metabolic post-hypercapnic alkalosis on the basis of clinical observation of a patient with severe hypercapnia and respiratory failure undergoing intensive care as well as treatment with iron lung (Pulmolife). The improvement of respiratory acid-base umbalance was associated with alteration of electrolytic assessment, especially of the plasmatic chloride ratio. The Authors consider this remark as a starting point for a physiopathological pattern and a more complete analysis of the pathways which generate the metabolic post-hypercapnic alkalosis condition in such patients.

Alkalosis↗
PubMed1979

[The use of oral potassium chloride (BS 560) in the treatment of mixed acid-base imbalance in patients with chronic broncho-pulmonary diseases].

The Authors, after giving an outline of metabolic alterations on acid-base balance in chronic obstructive lung disease, describe the need of correction of electrolytic umbalance, signally in relationship to metabolic alkalosis dued to hypochloremia. The Authors emphasize the importance of correction of jonic balance during long term therapy in such patients, especially diuretic and steroid long term treatment. The Authors studied the comparative effects on jonic assessment by correction with potassium chloride e.v. and potassium chloride by oral administration with a new capsulate preparation, (BS 560). Last they underline the good tolerance of this preparation and report the favourable effects on electrolytic patterns.

Acid-Base Imbalance↗
PubMed1976

[Gasometric changes and acid-base equilibrium of venous blood oxygenated in vitro and incubated with or without a phosphodiesterase inhibitor].

Changes in partial tension of the respiratory gases and in acid-base balance were studied in venous blood subjected to oxygenation, with or without incubation with theophylline. The following modifications were noted: 1) increased pO2; 2) decreased CO2 due to true wash-out caused by tonometry in oxygen; 3)decreased hydrogen ion concentration and bicarbonates following CO2 washing in both experimental models. A smaller reduction in pH and HCO3 was statistically significant in specimens treated with theophylline. This is seen as proof of the view that theophylline inhibits red cell membrane ion exchanges, such as to oppose or at any rate limit metabolic changes in acid-base balance induced by oxygenation.

Acid-Base Equilibrium↗