Apaf1 reduced expression levels generate a mutant phenotype in adult brain and skeleton.
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Biomedical subjects
Publications and source records attributed to E Ferraro.
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Primary ovarian leiomyosarcomas are rare neoplasms of the ovary, particularly in the pediatric population. Their occurrence following radiation therapy for previous malignancy has important implications. We present a case of primary ovarian leiomyosarcoma in an adolescent following therapy for medulloblastoma.
The Authors used two different materials: amalgam and composite, for the restoration of the same dental element. This type of reconstruction, defined as "mixed-restoration" is analysed both theoretically, demonstrating the principles which allowed its realization, and from a practical view-point, through the presentation of three clinical cases which clarify the technique used.
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Different cellular pathways can lead to apoptosis. Apaf1 is the molecular core of the apoptosome, a multiproteic complex mediating the so-called mitochondrial pathway of cell death. The importance of this pathway during development has been clearly demonstrated by knocking out key genes. Also, the relevance of Apaf1 dosage during development has been recently underlined. Moreover, a growing body of evidences seems to point out a possible role of the mitochondria-dependent apoptosis in different pathologies. In particular, we discuss here some recent evidences regarding the putative role of the apoptosome in neurodegeneration and cancer.
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