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Biomedical subjects

E Fineberg

Publications and source records attributed to E Fineberg.

5 recordsLinked to original sources
PubMed1979

Effect of iontophoretic and topical application of antiviral agents in treatment of experimental HSV-1 keratitis in rabbits.

Cathodal (-) iontophoresis of 9-beta-D-arabinofuranosyl-adenine 5'-monophosphate (vidarabine monophosphate; Ara-AMP) was performed once daily for 3 days for the treatment of experimental herpes simplex virus type 1 (HSV-1) keratitis in rabbit eyes, and the therapeutic efficacy was compared with that of topical treatment of Ara-AMP and idoxuridine (IDU) administered five times daily for 4 days. With the treatment initiated 24 hr after viral inoculation, Ara-AMP cathodal iontophoresis resulted in significant suppression of epithelial and anterior segment disease processes. Topical IDU (0.5%) or Ara-AMP (10%) also significantly improved the disease process when compared to the placebo-treated group; however, iontophoresis of Ara-AMP resulted in a more marked improvement. Slit-lamp examination indicated that iontophoresis did not cause any observable pathologic changes in corneal epithelium, stroma, conjunctiva, or iris of rabbit eyes. This experiment suggests that iontophoresis of Ara-AMP is a safe and effective approach for preventing the development of herpes simplex keratitis in rabbits.

Administration, Topical↗
PubMed1977

A stable base for an operating microscope.

We developed a 1/4-inch mild steel plate underbase with reinforced steel angles and three-inch diameter casters for our nonmotorized operating microscope floorstand. When fully weighted with an automatic focus zoom microscope head, a stereoscopic assistant scope, and a television camera, the unit proved stable and safe. It can be moved more easily than the existing floorstand.

Humans↗
PubMed1975

Proliferation and metaplasia of intravitreal retinal pigment epithelium cell autotransplants.

Pigment epithelium cells autotransplanted into the vitreous cavity of owl monkey eyes, proliferated and metaplased. The metaplastic cells looked like pigmented macrophages, membrane forming fibrocyte-like cells, and frank epithelium cells. This in vivo experiment demonstrated that the vitreous cavity is an adequate culture medium for cells deriving from the pigment epithelium and that pigment epithelium cells could be the source of intraocular proliferation seen in massive periretinal proliferation.

Animals↗
PubMed1975

Sulfur hexafluoride in owl monkey vitreous cavity.

Sulfur hexafluoride (SF6) gas, tested in the vitreous chamber of owl monkey eyes, remained in the vitreous cavity about twice as long as air (ten to 11 days vs. five to six days). Its volume expanded from the diffusion of other gases into the created gas pocket. Lens opacities developed when the lens was in continuous contact with SF6 or air. Sulfur hexafluoride appeared to be no more toxic to the retina than air, using electroretinographic, histologic, and electron microscopic criteria.

Air↗