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Biomedical subjects

E Flatau

Publications and source records attributed to E Flatau.

At least 19 recordsLinked to original sources
PubMed1992

[Pyogenic liver abscess caused by Streptococcus milleri].

Streptococcus milleri is a facultative anaerobic pathogen of the viridans group associated with serious suppurative infections, mainly abscesses. We saw 3 cases of liver abscess due to this organism in 1990 in women aged 43, 59 and 67 years, respectively. The coccus was grown from blood cultures in 2 of the cases and from abscess drainage in the 3rd. The importance of prompt diagnosis of liver abscess by means of CT and ultrasonography is stressed. Conservative treatment consists of CT-guided percutaneous drainage, followed by prolonged antibiotic treatment. Such conservative measures avoid complex and sometimes hazardous surgical procedures.

Adult↗
PubMed1992

[Antibodies against double-stranded and single-stranded DNA in the aged].

Sera from 183 healthy, elderly subjects and 92 young, control subjects were tested by the Elisa method for antibodies against double-stranded (ds) and single-stranded (ss) DNA, and sera from the elderly were tested for antinuclear antibodies as well. Significantly higher levels of anti-ss-DNA were found in the elderly, but levels of anti-ds-DNA did not differ significantly; no sera positive for anti-ds-DNA were found. levels of antibodies to DNA were similar in men and women. In those 85 and over, mean levels of anti-ds-DNA were lower than in those 65-84 (63 vs. 44, p less than 0.05). 13 of those over 65 (7.1%) tested positive for antinuclear factor, 2 of whom had positive titers of anti-ss-DNA. The results of this study support the hypothesis that elevated levels of anti-ss-DNA are age-related and not disease-related.

Aged↗
PubMed1990

Clindamycin in the treatment of an outbreak of streptococcal pharyngitis in a kibbutz due to beta-lactamase producing organisms.

During the winter of 1987-88, an epidemic of streptococcal pharyngitis (SP) affected almost 25% of the 800 inhabitants of a community settlement (kibbutz), and failed to respond to treatment with penicillin and/or erythromycin, despite the fact that the streptococci were highly sensitive to penicillin (minimum inhibitory concentration: MIC less than 0.001 micrograms/ml). We suggested that the concomitant presence of beta-lactamase producing organisms in the pharyngeal cavities of the affected individuals with SP could inactivate the antibiotics, rendering the streptococci resistant to penicillin. Throat swabs were taken and tested for aerobic and anaerobic beta-lactamase producing organisms and for beta-lactamase activity and clindamycin treatment was given to 110 patients with SP. Beta-lactamase activity was detected in 90 cases and the cultures were positive for Staphylococcus aureus (25 cases), Haemophilus sp. (22 cases) and anaerobes, which we did not identify in 68 cases. Ninety-eight patients completed the ten-day course of treatment with clindamycin and 96 were cured clinically and bacteriologically. The epidemic was controlled.

Adolescent↗
PubMed1989

[Tuberculous meningitis].

2 cases of tuberculous meningitis are presented, 1 in a 54-year-old woman who had immigrated to Israel from Turkey 36 years before, and the other in a 10-year-old girl who recently immigrated from Ethiopia. Since diagnosis is difficult and prompt antituberculous treatment is life-saving, treatment may be instituted before the bacteriological diagnosis is established. A short term treatment of 9 months and a combination of rifampicin and isoniazid were successful in our patients.

Child↗
PubMed1989

Determination by ELISA of anti-DNA antibodies in patients with familial Mediterranean fever.

Positive titers of antibodies against double-stranded (ds) and single-stranded (ss) DNA were found in the sera of 4 and 6 patients, respectively, of 18 who had familial Mediterranean fever (FMF). While anti-dsDNA antibodies were found only in patients with active disease, there was no correlation between the presence of anti-ssDNA antibodies and disease activity. The antibody titers were lower than those found in patients with active systemic lupus erythematosus. This may be due in part to the fact that all the FMF patients were treated with colchicine.

Adult↗
PubMed1985

Extraosseous accumulation of 99mTc-MDP in a benign intrapulmonary calcified focus.

A patient with a benign calcified pulmonary focus concentrating 99mTc-methylenediphosphonate is described. To the best of our knowledge, this is the first description of the accumulation of 99mTc-phosphate compounds in a benign calcified focus of the lung. The value of a routine correlation with X-ray study in every case of focal chest concentration of 99mTc-MDP is emphasized.

Bone and Bones↗
PubMed1977

Variability of splenomegaly in Crohn's disease.

Splenomegaly is an unusual finding in Crohn's disease and can be persistent or transient. In three febrile patients it was so prominent that the diagnosis of lymphoma was considered. In two additional patients the splenomegaly was an incidental finding. It is probably a nonspecific response to the basic disease in most cases, or occasionally a response to the chronic liver disease that can occur in inflammatory bowel disease.

Abdominal Neoplasms↗
PubMed1976

The influence of oral glucose loading on the insulin response to i.v. glucagon in children and adolescents.

Fourteen children and adolescents with slight constitutional growth retardation (12 males and two females) aged from 7 1/2 to 18 1/2 yr underwent an oral glucose tolerance test (OGTT 1.75 g/Kg followed at 180 min by an i.v. glucagon injection (0.03 mg/Kg). On a separate occasion these children underwent a simple i.v. glucagon test. Comparing the glucose and insulin response in the two glucagon tests for each child we found that whereas in the single test the blood glucose rose slowly with a peak at 30 min, in the combined test the peak was at 5 min. The mean peak values were similar (129 and 121 mg/100 ml). The mean peak insulin response in the single test was 70 muU/ml (at 2 min) as compared to 253 muU/ml (at 2 min) in the combined test. Our studies provide further evidence for a direct effect of glucagon on insulin release and that glucose preloading augments this effect, without relation to the concomitant blood glucose concentrations.

Adolescent↗
PubMed1976

Response to LH-RH and HCG in two brothers with the Reifenstein syndrome.

Two brothers with Reifenstein syndrome underwent LH-RH and HCG tests at various ages ranging from 13 to 17 years. We found that at age 13 the plasma LH and FSH response to one LH-RH injection was normal. After the age of 14, the basal plasma concentration of LH and FSH and their response to LH-RH became elevated. Concomitantly the plasma testosterone levels rose to abnormal levels. These findings are compatible with progressive development of primary gonadal dysfunction and with peripheral insensitivity to testosterone.

17-Ketosteroids↗