PubMed Health⌕ Search

Biomedical subjects

E Forsythe

Publications and source records attributed to E Forsythe.

4 recordsLinked to original sources
PubMed2006

Sexual rehabilitation of women with a spinal cord injury.

STUDY DESIGN: Literature review and a qualitative study. OBJECTIVE: This article reviews literature examining the sexual rehabilitation of women following spinal cord injury (SCI). It includes recommendations for improvements in initial clinical rehabilitation efforts and counselling services. SETTING: United Kingdom, Denmark and Sweden. METHODS: Articles concerning sexual rehabilitation following SCI from the last two decades have been reviewed and critiqued. Qualitative results from discussions with women with SCI in Denmark and Sweden are presented. RESULTS: The literature focuses on the effect of neurological change on women's ability to achieve sexual arousal and orgasm. Urinary and bowel incontinence, spasticity, vaginal lubrication and autonomic dysreflexia are the physical consequences of SCI that appear to have most impact on sexual activity. More recent studies have acknowledged that psychosocial factors such as age and partnership status may also affect the successful sexual rehabilitation. Discussions with women with SCI in Denmark and Sweden on their reactions to information and counselling offered during rehabilitation revealed an overwhelming need for the exchange of information and experience with other women with SCI, and a desire for opportunities for counselling after initial rehabilitation. CONCLUSION: Successful sexual rehabilitation of women with SCI demands a holistic approach that considers individual neurological, physical and psychosocial circumstances. Peer-counselling could make a significant contribution to the sexual rehabilitation of women with SCI.

Autonomic Nervous System Diseases↗
PubMed1994

Studies on tetragonal lysozyme crystal growth rates.

A computer-controlled apparatus able to simultaneously follow the face growth rate of up to 40 crystals was developed. This apparatus was used to investigate the effects of solution pH on the (110) and (101) face growth rates of tetragonal lysozyme. Growth rates were measured at pH 4.0, 4.4, 4.8 and 5.2, in 0.1 M sodium acetate buffer with 5% NaCl, 295 K. Initial crystal sizes ranged from 10 to 40 microm. Plots of log supersaturation ratio (either C/C(sat) or C/C(sat) - 1) versus log(growth rate) are not linear, typically having a slope of approximately 8 at the lowest growth rates determined (10(-6) microm s(-1)), which falls off to a slope of approximately 2 at the highest growth rates (10(-2) microm s(-1)) measured. Ratios of C/C(sat) ranged from 4 to >20. The data show that lower solubility solutions require higher supersaturation ratios for equivalent growth rates. Data for the growth rate of the (101) face at pH 4.0 were widely scattered, especially at lower supersaturation ratios. Time-lapse video of crystals at low supersaturations shows that initially only the (110) faces grow, leaving 'notches' at the (110)-(110) corners. These corners then fill in and macro-steps appear on the (101) faces which rapidly move inward in the form of an octagon, restoring the crystal to a 'normal' appearance. This phenomenon has been observed for tetragonal crystals grown in either still or flowing solutions. Flowing solutions at lower supersaturations also gave cases where the corners did not fill in, with the (110) faces continuing to grow out until growth ceased.

Journal Article↗
PubMed1994

Orthorhombic lysozyme solubility.

The orthorhombic, or high-temperature, form of chicken egg-white lysozyme typically appears at temperatures >/=298 K. Solubility diagrams have been determined for this form of lysozyme from pH 4.0 to 5.4 in 0.2 pH increments using the micro-column technique. Data were collected in the 297-317 K temperature range which resulted in phase diagrams similar in overall shape to those obtained for the lower temperature tetragonal form. Specifically, the solubility increased with increasing temperature and decreased with increasing precipitant concentration. However, the solubility of the orthorhombic form is considerably less sensitive to temperature than the tetragonal form, resulting in a more flattened slope. On the other hand, pH effects on the high-temperature form were opposite to those on the low-temperature form. When holding the precipitant concentration constant, the solubility decreased with increasing pH for the orthorhombic form. Previous tetragonal data were incorporated with these orthorhombic data to produce intercept values. These values varied with both pH and precipitant concentration, but the general tendency of the slope was to decrease with increasing pH.

Journal Article↗