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Biomedical subjects

E From

Publications and source records attributed to E From.

At least 37 records · Page 2Linked to original sources
PubMed1985

Biological false positives to serological tests for syphilis in herpes genitalis.

A survey was made of 17 patients (4 females and 13 males) with herpes genitalis who, during period 1971-84, developed biological false positive serological tests for syphilis. Of 121 patients with herpes genitalis diagnosed by herpes culture in 1982-84, 4.1% developed biologically false positive reaction. Duration of symptoms before biologically false positive reaction was 12 days. Duration of false positive reaction was on average 32 days. Eight had borderline reactions, 7 uneven positive titers and 2 serological patterns simulating secondary syphilis.

Adolescent↗
PubMed1983

Fluctuations in natural killer cell activity in early syphilis.

The natural killer cell activity was studied in 25 patients with primary, secondary, or latent syphilis before and after treatment. In primary syphilis natural killer cell activity was increased, especially in patients lacking circulating lipoidal antibodies. In patients who had become seroreactive in the lipoidal tests it was depressed in those with secondary and latent syphilis. The natural killer cell activity thus becomes activated by the syphilitic infection but is significantly reduced during progression of the disease. The importance of the natural killer cell activity in controlling syphilitic infection is questionable.

Adolescent↗
PubMed1982

Alterations in T lymphocytes and T-lymphocyte subpopulations in patients with syphilis.

The distribution of T-lymphocyte subpopulations was studied in 34 patients with primary or secondary syphilis before and after treatment. An absolute and relative T lymphopenia was found in all patients. In primary syphilis the concentration of helper cells--T cells with Fc receptors for IgM (T mu)--was low whereas in secondary syphilis the suppressor cell concentration--T cells with Fc receptors for IgG (T gamma)--was reduced. Using lymphocytes from healthy subjects this could be imitated in vitro by the addition of serum from patients with secondary syphilis. In many autoimmune diseases a low concentration of T gamma may be a primary factor in the production of autoantibodies. The occurrence of similar changes in patients with secondary syphilis, however, indicates that such fluctuations in the T-cell subpopulations may take place during a strong immune response.

Adolescent↗
PubMed1982

The role of immune complexes in early syphilis and in the Jarisch-Herxheimer reaction.

Circulating immune complexes (CIC) were detected in one of 11 patients with primary syphilis and in 5 of 12 patients with secondary syphilis. The level of CIC was significantly increased in patients with secondary syphilis. Four weeks later a significant decline in CIC was found. No relationship was demonstrated between CIC and affection of the skin, lymph nodes, or kidneys. An increased albumin excretion rate was demonstrated before treatment. No differences were found in the excretion rate of beta-2-microglobulin before or after treatment. Nineteen patients had a Jarisch-Herxheimer reaction during treatment. An increase in CIC was found in 5 patients and a decrease in 7 patients. No correlation could be demonstrated between the level of or changes in CIC and the severity of the Jarisch-Herxheimer reaction.

Adult↗
PubMed1980

Some aspects of venereal diseases in Greenland.

For many years venereal diseases have been a major problem in Greenland. Since the early 1950s gonorrhoea has been widely prevalent; in the middle of the 1960s the incidence increased rapidly. Since the early 1970s syphilis has become widespread in the population, and in 1977 an epidemic of chancroid occurred. The high figures for venereal diseases are basically due to the social change towards a modern industrial society. Improvements in the health services could be made by encouraging health education on venereal diseases, training Greenlander health personnel, and appointing a venereologist.

Adolescent↗
PubMed1980

Prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae infections in Greenland. A seroepidemiological study.

In a sero-epidemiological study of the prevalence of chlamydial and gonococcal infections in Greenland three groups of subjects were studied--262 patients attending an outpatient department in the town of Nuuk (of whom 12% harboured Chlamydia trachomatis and 54% Neisseria gonorrhoeae), 63 controls from the same town, and the entire population of 150 in the settlement of Uvkusigsat. Using a microimmunofluorescence test evidence of exposure to C trachomatis was found in 79% of the female and 26% of the male patients, in 12% and 50% of the female and male controls respectively, and in 51% and 21% of the female and male populations of Uvkusigsat respectively. Using an indirect haemagglutination test antibodies to gonococcal pili were found in sera of 92% of the female and 70% of the male patients, in 30% of the male and 10% of the female controls, and in 41% of the women and 33% of the men in Uvkusigsat. The study indicates that genital chlamydial and gonococcal infections are serious public health problems in Greenland and that such infections are acquired early in both sexes and often occur concomitantly.

Adolescent↗
PubMed1978

Dyskeratosis benigna intraepithelialis mucosae et cutis hereditaria. A report of this disorder in father and son.

A congenital syndrome affecting the skin, oral mucosa and bulbar conjunctiva is reported in father and son. Skin lesions consisted of brownish papules with central keratotic plugs. Trauma was able to provoke lesions. In addition, changes of oral mucosa with premature loss of the teeth, and recurrent eye symptoms with conjunctivitis were present. Histological examination of specimens from skin, oral mucosa and conjunctiva revealed a uniform picture of dyskeratosis (single cell keratinization). The symptoms reported do not seem to fit into any of the existing muco-cutaneous syndromes. An autosomal dominant mutation is suggested as the cause of the disease.

Adult↗
PubMed1978

Circulating immune complexes in syphilitic nephropathy. A case report.

A case of transient nephrotic syndrome caused by secondary syphilis is described. A renal biopsy was performed revealing subepithelial hump-like electron-dense deposits and fusion of epithelial foot-processes. Complement C1q-binding-activity and anticomplementarity were demonstrated in the blood, indicating the presence of circulating immune complexes. This strongly suggests that circulating immune complexes are significant in the immunopathogenesis of syphilitic nephropathy.

Adult↗
PubMed1978

Circulating immune complexes in syphilis.

13 patients with syphilis were investigated regarding the presence of circulating immune complexes by the methods of C 1q-binding-activity and anticomplementarity. Elevated C1q-binding-activity was demonstrated in 6 of 7 patients with secondary syphilis, a significantly greater incidence than among patients with primary syphilis and neurosyphilis. Anticomplementarity was demonstrated in five of seven patients with secondary syphilis and in two patients with neurosyphilis. Anticomplementarity was found in only one of four patients with primary syphilis. The presence of immune complexes may be of importance in the aetiology of some of the lesions of secondary and perhaps tertiary syphilis.

Antigen-Antibody Complex↗
PubMed1976

Reactivity of lymphocytes from patients with syphilis towards T. pallidum antigen in the leucocyte migration and lymphocyte transformation tests.

The reactivity of lymphocytes to Treponema pallidum antigen was studied before and after treatment in nine patients with early syphilis using a leucocyte migration test and a lymphocyte transformation test. Lymphocyte reactivity was also investigated in six patients treated for syphilis within the last 4 years, and in five untreated patients with a positive result to the T. pallidum immobilization test, but negative results to other serum tests for syphilis antibodies and without any known exposure to risk of infection by syphilis. Ten seronegative patients with different dermatological disorders served as a control group. A significant increase in lymphocyte reactivity to T. pallidum antigen was recorded in both tests in vitro after treatment. There was no difference in lymphocyte reactivity to T. pallidum antigen between the other patients studied and the control group. In early syphilis the spontaneous migration was found to be inhibited before treatment. Tuberculin skin tests were also performed and found to be suppressed in patients with primary and secondary syphilis. No difference in phytohaemagglutinin response was found between any of the groups. Plasma from patients with primary and secondary syphilis was found to change the in vitro reactivity of normal lymphocytes when stimulated with different mitogens.

Antigens, Bacterial↗
PubMed1975

Methotrexate pneumonitis in a psoriatic.

A life-threatening respiratory disease, characterized by fever, cough, dyspnoea, cyanosis and wide-spread bilateral pulmonary infiltrates, developed in a 40-year-old patient receiving intermittent methotrexate therapy for psoriasis. Blood eosinophilia accompanied the illness. A prominent feature in the clinical picture was a discrepancy between auscultatory findings and the pronounced changes in the chest X-ray. Systemic corticosteroids produced rapid improvement. It is suggested that the pulmonary syndrome represents a hypersensitivity reaction.

Adult↗
PubMed1975

Trimethoprim-sulphamethoxazole in gonorrhoea. A comparison with privampicillin combined with probenecid.

419 patients with uncomplicated gonorrhoea were treated with sulphamethoxazole 4 g. combined with trimethoprim 0-8 g. divided into two doses with an 8-hr interval. The failure rate was 1-9 per cent. Parallel with this trial, 319 patients received pivampicillin 1-4 g. combined with probenecid 1 g,; the failure rate was 0-9 per cent. Side-effects were few, four patients in the first group and one in the second group developing a rash. No recurrences were noted in nine patients treated for tonsillar gonorrhoea with the trimethoprim-sulphamethoxazole schedule, while two recurrences were found in thirteen patients treated with pivampicillin-probenecid. The frequency of post-gonococcal urethritis was 7-7 per cent. in the pivampicillin-pro-benecid group against 3-4 per cent. in the trimethoprim-sulphamethoxazole group, a difference which was not statistically significant.

Ampicillin↗