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Biomedical subjects

E Fromm

Publications and source records attributed to E Fromm.

At least 37 records · Page 2Linked to original sources

The effect of an extraluminal transducer on the reproductive capability of the rabbit.

An extraluminally attached microminiature force transducer, designed for reproductive tract contractility measurements, was investigated in terms of its effects on the physiology of the uterotubal junction in the rabbit. The presence or attachment process of the extraluminal force transducer (EFT) did not affect the rate of pregnancy or the number of embryonic implantation sites whether the attached device was silicone rubber or polyethylene-encased. The uterotubal junction was able to retain the blastocyst for the required time after mating, while an examination of postembryonic mortality revealed a rate of one resorption in some experimental groups. The gestation period was unaffected by the EFT, ranging from 30 to 40 days with a mode of 32, while histologic examinations revealed formation of a thin fibroblastic layer, some increased vascularity, and no abnormal leukocytic accumulation.

Animals

Studies of rabbit ovarian contractility using chronically implanted transducers.

A chronically implanted, highly sensitive force transducer was used to study ovarian contractions in the rabbit. The transducer is implanted into the medulla of the ovary through its long axis. The leads are then drawn through the abdominal wall and directed subcutaneously to the back of the neck. The miniature pin connector is fixed into place beneath the skin to facilitate accessibility for repeated recordings, obviating the necessity for anesthesia or serial laparotomies. Intraovarian transducers were implanted in isolated rabbits. Serial recordings of ovarian contractions were made at weekly intervals for 3 weeks, following which ovulation was induced with 100 IU of human chorionic gonadotropin (HCG). Extended recordings were made from 3 through 13 hours after HCG administration to six animals. Recordings revealed increased ovarian contractile activity beginning just before the anticipated time of ovulation. The observations support those of previous acute experiments and demonstrate a relationship between ovarian contractile activity and the process of follicle rupture.

Animals