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Biomedical subjects

E Fuchs

Publications and source records attributed to E Fuchs.

At least 361 records · Page 20Linked to original sources
PubMed1979

[The "rubtest" and RAST].

The "rubtest" to induce an immediate reaction with various inhalative and ingestive allergens has proved to be a very reliable, easily demonstrable and extremely simple method for detection of allergy-type I, especially of the "highest-sensitivity-type". Recent examinations confirmed the clinical importance and the high correlation between the "rub-test", the IgE-titre (RAST) and the endpoint-skin test-titration.

Allergens↗
PubMed1979

[Clinical diagnosis of allergy (author's transl)].

"Allergic" manifestations are not necessarily of allergic origin; they can also be produced by non-allergic factors and their true allergic nature must, therefore, be proved. A detailed personal history and the presence of eosinophilia (in the blood or secretions) are suggestive evidence which has to be confirmed by the identification of specific antibodies of the immunoglobulin-E type. Criteria for arriving at the diagnosis "allergy" are (a) demonstration of antibodies by skin and mucous membrane tests with allergen extracts; (b) demonstration of the activity of the identified allergen by challenge tests on the reacting organ (conjunctiva, nose, bronchi); (c) in-vitro demonstration of the allergen-specific immunoglobulin-E by means of the radio-allergo-sorbent test. Details for the performance of the various tests are given and the interpretation and significance of the findings are discussed.

Allergens↗
PubMed1979

[Obstructive diseases of the respiratory tract caused by industrial allergens (author's transl)].

Obstructive diseases of the respiratory tract caused by allergising substances at the place of work, must be classified and compensated as occupational diseases - provided certain conditions are fulfilled - according to item No. 4301 of the currently valid Industrial Health Insurance legislation. The article discusses the aetiopathogenesis as well as the special features of clinic and diagnosis of occupationally conditioned allergic obstruction of the respiratory tract, previously known as asthma bronchiale. In contrast to "spontaneous" allergy, the occupational cause of the disease is due to the often massive exposition to allergens at the place of work, as well as the frequently aggressive potency of several industrial allergens, these being considered as the actual "shaping" factors. The article stresses the need for early diagnosis, as far as possible already in the is allergic conjunctivitis and rhinitis. Treatment directed at removing the causes includes, fundamentally, prophylaxis against exposure (considering the time during which the allergens remain dormant without triggering an allergy); obviously, this involves change of occupation or place of work, whereas specific treatment aimed at producing hyposensibilisation must remain an exception. The article concludes with a description of the possibilities of prevention mainly from the medical point of view.

Air Pollutants↗
PubMed1978

The expression of keratin genes in epidermis and cultured epidermal cells.

Cultured human epidermal cells and human stratum corneum (callus) contain a number of keratins of different molecular size, but the size distribution is not the same in the two cases. To characterize these keratins in more detail, we compared them by amino acid analysis, immunological reactivity and one-dimensional peptide mapping (Cleveland et al., 1977). No differences in amino acid compositon could be detected among keratins of stratum corneum differing in molecular size by as much as 50%, suggesting that some repeating structure may be present in these molecules. Examination of polypeptide fragments produced by partial enzymatic hydrolysis showed strong similarities among all the keratins of stratum corneum and of cultured epidermal cells, even extending to the keratins of rodents; but the keratins of similar size, whether of stratum corneum or cultured cells, were more closely related than keratins of different size. This conclusion was supported by studies of the immunological reactivity of the keratins. How the epidermal cell generates a family of keratins is a problem of considerable interest. The differences in size and structure between the keratins of stratum corneum and cultured epidermal cells suggest that the epidermal cell can modify the expression its keratin genes.

Amino Acids↗
PubMed1978

Short RNA chains synthesized at low pH are initiated at promoter sites.

Under non optimal conditions- either with limiting substrate concentrations (1) or at low pH (2)- RNA polymerase of Escherichia coli synthesizes very short RNA chains. By sequencing one RNA species synthesized at pH 5.8 upon T7 DNA we were able to demonstrate that under these conditions transcription is initiated at a normal promoter site (here A1) but however is terminated soon afterwards at specific artificial sites not used in vivo.

Binding Sites↗
PubMed1977

Propantheline as a diagnostic tool--a serious complication.

Propantheline bromide is a synthetic quaternary ammonium compound widely used in urologic patients to block the action of acetylcholine at the postganglionic nerve endings of the bladder's parasympathetic innervation. It is used clinically in a wide range of doses in ambulatory outpatients as well as hospitalized patients. To document its effects on the bladder, test doses are given with a cystometrogram documenting the dynamic changes. Herein we report a case of serious cardiac toxicity from a diagnostic test dose.

Aged↗
PubMed1977

[Studies on influence of intensity factors on the population dynamic of migratory root nematodes with special consideration of the genus Pratylenchus Filipjev. III. Influence of three years irrigation (author's transl)].

Results of a field experiment on the effect of three years irrigation on the population dynamic of migratory nematodes of the cereals are described. In case of constant high moisture content the Pratylenchus spec. were inhibited. A cumulation of this effect during three years was not observed. The influence was only low on the species of the genus Tylenchorhychus, Paratylenchus, on the species of the families Aphelenchoididae/Aphelenchidae, Dorylaimidae, and on the saprophytic nematodes of the order Rhabditida.

Animals↗