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Biomedical subjects

E G Gilerovich

Publications and source records attributed to E G Gilerovich.

14 recordsLinked to original sources
PubMed1990

[Transplantation of embryonal nerve tissues in the treatment of Parkinson disease].

The authors describe the results of experimental studies of transplants of embryonal nervous tissues of man in the brain of adult animals. Base the use of transplantation of the embryonal dopaminergic structures for the treatment of patients suffering from parkinsonism. Provide the first results of the treatment of 2 patients suffering from parkinsonism by means of transplanting parts of the medium cerebral vesicle of human embryos. The observation period amounts to 6 months.

Animals↗
PubMed1990

[Structural basis of developmental changes in the cytoarchitecture of human neocortex transplants].

Early stages in development of transplants of the embryonal anlages of the human neocortex into the brain of mature rats have been studied at light optic level. The main attention has been paid to processes of proliferation, migration and differentiation of cells. Increasing amount of cells in the transplants takes place only at the expense of neuroepithelium; its reorganization results in a peculiar rearrangement of cells with formation of so called rosellas with numerous mitotically dividing cells. Owing to this growth the differentiating cells migrate from the rosellas radially, unlike their layer-by-layer organization in the control. These deviations are probably dominant in the disturbance of cytoarchitectonic organization of cells in transplants of neocortex in mature mammalia.

Animals↗
PubMed1990

[Transplantation of human embryonal nervous tissue to the spinal cord of mature rats].

Pieces of the wall obtained from the anterior cerebral bladder of human embryos at the age of 8-10 weeks can survive in the spinal cord of mature animals. In the transplant, unlike the normal embryonal histogenesis, neuroepithelial cells make groups of rosellas. The differentiation process of cells of the human nervous tissue transplant can be followed in the rat spinal cord without any immune suppression up to the end of the 2d month of development. During the 3d month the transplant neuroblasts perish as a result of the immune reaction.

Age Factors↗
PubMed1989

[The role of the neurons of the locus coeruleus and ventral tegmental area in the development of catecholamine-deficient conditions].

Selective neurotoxic effect of 6-hydroxydopamine on the catecholaminergic systems was used to study the structural changes in the locus coeruleus and ventral tegmental neurons. Compared with the earlier published data on the blood-brain barrier permeability, the peculiarities of the responses of a part of neurons and synapses of the sites under study suggest that this selective catecholaminergic systems lesion leads to a decrease in their influence on the brain structures innervated. This causes impairment of inter-neurotransmitter relations and provide a morphological basis of various functional CNS shifts.

Animals↗
PubMed1985

[Transplantation of embryonal anlagen of the human neocortex into the brain of the rat].

A possibility for transplanting anlages of human embryonal neocortex into mature rat brain has been studied. Light- and electron-microscopic investigations demonstrate that the embryonal tissue of the human neocortex implants into the cerebral grey and white substance of mature rats. In the grafts cellular elements proliferate and differentiate, neuropil is formed. These results open certain perspectives for modelling investigations on histogenesis of neural tissues and on studying possibilities for clinical use of grafts of the human embryonal brain.

Animals↗
PubMed1984

[Morphological restructurings in the brain due to a decrease in the catecholamine level].

Using light and electron microscopic examinations, the authors studied various portions of the rat brain following intracysternal administration of 6-hydroxydopamine. The lowered levels of noradrenaline in the cerebral tissue and an altered ultrastructure of neurons of the catecholaminergic centres and their processes were discovered in various areas of the brain. The time-course and the pattern of these readjustments may serve as a model for the investigation of the etiopathogenesis of various mental diseases and the elaboration of the methods of their pharmacotherapy.

Animals↗
PubMed1984

[Morphologic characteristics of locus coeruleus neurons after selective chemical damage to the catecholaminergic system of the brain].

The initial part of the noradrenergic cerebral system--the locus caeruleus neurons--has been studied light and electron microscopically at various time after injection of 6- hydrodopamine (6-OHDA), a substance possessing a selective neurotoxic effect on the catecholaminergic mediatory system. Intracisternal injection of 6-OHDA (300 mcg) produces a number of reactive rearrangements in the neurons and large dendrites. Nevertheless, the death of the neural cells is not observed even by the 36th day.

Animals↗
PubMed1979

[Localization of ATPase in the cerebral cortex and its role in the functional activity of neurons].

By analogy of defensive conditioned reflex formation in rats using a cytochemical method, dependency of localization and concentration of the product of ATP-ase activity on neuronal and synaptic functional activity has been demonstrated. It corresponds to the notion that only a part of the cortical cells are simultaneously at the state of structural-functional activity. The experimental data demonstrate that the CNS excitation in the animals during the process of learning is connected with increasing ATP-ase activity in ultrastructures of the nucleolus, pericaryon and synapses of some neurons participating in the formation of trace processes in the brain.

Adenosine Triphosphatases↗
PubMed1979

[Changes in the ultrastructure and protein fractions of the cortex of the motor and visual analyzers during conditioned reflex avoidance reactions].

In avoidance conditioning, rats developed changes in the range of electrophoretic proteins as well as subcellular reconstructions in neurons and synapses which enabled them to fulfill specific functions on the basis of genetically fixed biochemical processes and ultrastructures. This corroborates ideas of information storage in the c. n. s. on the basis of formation of certain neuronal ensembles by means of changes in neurons' synapses facilitating the conduction.

Animals↗
PubMedDate not supplied

[Morphofunctional characteristics of the associative region of the cerebral cortex in experimental neuroses in the dog].

Ultrastructure of neurones and synapses of the cortical associative area of dogs has been studied under conditions of experimental neuroses caused by prolonged informational loads with constant time deficit and high motivational signals significance. Analysis of subcellular reorganization of a number of neuronal and synaptic organelles showed the degenerative changes of afferent conducting systems in various neuropil parts leading to the falling out of definite neuronal groups from stable functional connections and to the disturbance of intracortical interrelations. In the cortex simultaneously with destructive processes, are developing intracellular compensatory-adaptive reactions.

Animals↗