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Biomedical subjects

E G Larskiĭ

Publications and source records attributed to E G Larskiĭ.

At least 19 recordsLinked to original sources
PubMed1992

[Pathological status of catecholamines in the corpus striatum in hepatocerebral dystrophy (Wilson-Konovalov disease)].

The content of catecholamines in the striatum was measured in 2 patients suffering from hepatocerebral dystrophy (Wilson-Konovalov disease). It is noted that in different clinical manifestations of the disease, the changes in the content of noradrenaline in the striatum varied. A male patient with marked tremor spreading manifested a considerable rise of the content of catecholamines, primarily in the n. caudatus. At the same time in a female patient with a grave akinetic -rigid syndrome and the signs of liver failure, the content of catecholamines, particularly dopamine, in the putamen was low. In view of this fact it is assumed that disorders of cerebral metabolism of catecholamines, dopamine in particular, evidently related to deposition of excess copper, leading to the changes of their content in basal ganglia underline the clinical pleomorphism of the disease and play the key role in the development of extrapyramidal motor disturbances characteristic of hepatocerebral dystrophy.

Adult↗
PubMed1991

[A micromodification of the method of determining the activity of processes of free radical oxidation].

A micromodification of the method for registration of bivalent iron ion-initiated chemiluminescence of the apo-beta-lipoprotein total fraction isolated from the blood serum is described. A significant elevation of lipid peroxide levels and of lipid ability to oxidation, paralleled by reduced levels of endogenous antioxidants as against the norm were revealed in the patients with acute disorders of brain circulation with the use of this method. Chemiluminescent studies of lipid peroxidation processes permit monitoring lipid peroxidation reactions and thus obtain a complex of parameters that characterize the status of these processes in the studied system. Due to its high sensitivity and specificity, chemiluminescent analysis may become one of the principal methods in studies of lipid peroxidation processes.

Cerebrovascular Disorders↗
PubMed1990

[A comparative evaluation of the efficacy of methods of determining osmolality and middle molecules in the prognosis of the course of strokes].

The authors compare the efficacies of methods for assessing osmolality (OSM) and analysis of medium molecules (MM) in the prediction of the post-stroke period course in the first 7 days from the stroke onset. Prognostically unfavorable MM and OSM values were found, predicting the possible lethal outcome. On the whole the MM index was found 1.7 times more sensitive for this prediction than the OSM index; the possibility of predicting a lethal outcome from the MM value within the first 24 hrs was 3 times higher and within the first 48 hrs 4 times higher vs. the OSM value.

Adult↗
PubMed1990

[Endogenous toxemia in acute disorders of cerebral circulation].

Critical conditions that develop because of hypoxia of different genesis are accompanied by endogenous intoxication induced to a considerable degree by the appearance in the blood of an excess amount of medium-sized molecules (MSM). An appreciable increase of the content of MSM was demonstrated since the very first days after the brain stroke as a result of examining 100 patients who suffered brain stroke, including 83 patients during the first week of the disease and 17 patients of the reference group with a history of acute impairment of cerebral circulation which had occurred over a month before. A reverse correlation was established between the level of endogenous intoxication and the clinical status of the patients which could be observed every day during the acute disease phase. The critical level of MSM was determined in the patients' blood plasma. In the majority of cases, the attainment of the above level resulted in a lethal outcome irrespective of the pattern of acute impairment of cerebral circulation. The data obtained make it possible to recommend using the level of MSM as one of the simple and rapid quantitative methods for assessment of the patients' status gravity and monitoring of persons with acute impairment of cerebral circulation.

Acute Disease↗
PubMed1990

[Catecholamine metabolism in extrapyramidal disorders in patients with chronic hypertensive encephalopathy].

Total and cerebral metabolism of catecholamines (CA) was examined in patients with associated chronic hypertonic encephalopathy and extrapyramidal disorders. It was discovered for the first time that there was an increase in noradrenaline in the blood and cerebrospinal fluid together with a lowering of the content of dopamine and major metabolite thereof along the pathway of oxidative deamination of homovanillic acid. CA metabolism was shown to correlate with the patients' age, duration and gravity of extrapyramidal disorders. It is suggested that the revealed metabolic disorders of CA--neurotransmitters which are likely to underlie the development of neurological deficiency and characteristic mental disorders occur as a result of the diverse complex of biochemical alterations and are related both to the complex mechanisms of the pathogenesis of essential hypertension and ischemic injury to the brain as well as to the localization in the brain of lacunar infarctions. The complexity of the pathogenic treatment of the disease is emphasized. The main approaches to the pharmacological correction of the revealed disorders are outlined.

Adult↗
PubMed1989

[Analysis of the composition of the microelements in the hair of normal subjects and in disseminated sclerosis].

The modification of analysis of the hair trace elements involves hair dissolution in nitric acid and analysis of the iron, manganese, and copper by flameless atomic-absorption spectrometry and of zinc by the flame technique. Trace element content has been measured in the hair of 26 normal subjects aged 20-50 and of 20 children. In adults iron, manganese, zinc, and copper concentrations were 12.2 +/- 0.6, 0.55 +/- 0.11, 172 +/- 8, and 12.8 +/- 0.6 micrograms/g, respectively. Higher concentrations of manganese have been observed in females, as well as a tendency to an increase of zinc levels in adults. Analysis of copper in the hair of 44 patients with disseminated sclerosis, carried out by the suggested technique and by direct analysis of the solid sample in a graphite cuvette, has revealed a trend to an elevation of copper content vs. the norm. No significant differences between the hair manganese levels of females and males have been revealed in the patients, such differences being typical of normal subjects. Fluctuations in copper concentrations at different sites of a single hair and a strand have been analyzed in the patients and in normal subjects.

Adult↗
PubMed1989

[Use of a conductometric detector in capillary isotachophoresis of blood serum proteins].

Conductometric detectors can be employed for analysis of the blood serum proteins. Conductometric curves of various sera show at least 12 peaks corresponding to certain protein fractions and inorganic components. Isotachophoresis of individual protein preparations detects impurities in them. The type of conductometric curves of various blood sera helps diagnose abnormal shifts. Use of a spacer is not conducive to a more accurate detection of the blood serum protein compounds.

Blood Protein Electrophoresis↗
PubMed1989

[Ceruloplasmin activity in the blood during progressive diseases of the central nervous system].

Ceruloplasmin (CP) preparations have been used as the reference agents in transition of this protein oxidase activity to blood serum concentrations; the mean concentrations of serum CP varied from 175 to 310 mg/l, depending on the biochemical characteristics of the preparations. Adjustment by the blood serum copper level has proved adequate for clinical studies. CP activity has been found increased in some patients with disseminated sclerosis and lateral amyotrophic sclerosis. CP activity grows with age in normal subjects and in the patients with hereditary extrapyramidal and cerebellar diseases and phenocopies thereof (except hepatocerebral dystrophy). CP activity is higher in women than in men.

Adolescent↗
PubMed1989

[Analysis of trace elements of the brain and liver tissues in Wilson's disease].

In a patients with extrapyramidal-cortical form of the Wilson-Konovalov disease, brain and liver tissues were tested for Ca, Cu, Fe, Ka, Mg, Mn, Mo, P, Pb, Se, Sn, Sz, Zn, S, using plasma emission spectrometry. The tissues autopsied from 2 cerebral hemorrhage victims served as controls. Hepatic Cu concentration was increased 24-fold (6.89 mumole/g of tissue dry weight); Cu accumulation in the brain cortex and basal ganglia were 10 times as high as control levels; hepatic (8.78 mumole/g) and brain cortical (2.23 mumole/g) Zn contents were higher than controls, respectively by factors of 2 and 1.7; hepatic S content (289.4 mumole/g) was 1.2 times the control level; Mn brain content was above the control value. Mg was below the appreciable amount in the brain that was not the case in control. On the contrary, Sr was detected only in basal ganglia and liver in the patient and not detected in control tissues. Pb content in the patient's liver was above the control level.

Adult↗
PubMed1986

[Cyclic nucleotides in multiple sclerosis].

The authors studied concentrations of cyclic nucleotides (cAMP and cGMP), as well as their ratio in the blood plasma and cerebrospinal fluid (CSF) of 83 patients with disseminated sclerosis of different forms and variants. An elevation in cAMP concentrations in the plasma and CSF detected in all the patients was more expressed in cases of a long standing and disseminated process. Blood levels of cAMP showed greater variability in the period of exacerbation versus remission of the disease.

Adult↗