Neurosyphilis: is it really a reversible cause of dementia?
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Biomedical subjects
Publications and source records attributed to E G Margolin.
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A review of 431 outpatient geriatric assessments conducted over 2 years examined the associations of referral problems, assessment diagnoses, and therapeutic recommendations with the source of patient referral, as well as that referral source's diagnostic accuracy in identifying the referral problems. Families referred 52% of patients, primarily for problems of memory and behavior, whereas social service agencies made 32.9% of all referrals, primarily for bladder control problems or safety-related concerns. Physicians made only 6% of referrals in this setting. Referral source was found not to be associated with any of the seven categories of medical diagnoses resulting from the assessment process and was associated with only two of the functional diagnostic categories. Therapeutic recommendations were also broadly distributed among referral sources, though social service agencies did refer more patients who required urgent nursing home placement, financial representation, or adult protective service involvement. The performance of family referral sources in accurately referring patients with dementia and psychiatric impairment was comparable to that of physicians, though all referral sources frequently missed patients with incontinence. Non-physician referral sources appear to serve as important and quite valid case-finders for outpatient geriatric assessment.
Six patients are reported with nephrotic syndrome and relatively rapid progression to irreversible renal failure. The renal histologic findings are unusual. The most striking changes are collapse of glomerular capillary loops, such as might occur with glomerular hypoperfusion; significant tubulointerstitial damage is also seen. These patients appear to have a clinicopathologic entity hitherto unreported. Its differentiation from other causes of progressive glomerular damage, and particularly from focal and segmental glomerulosclerosis, is discussed.
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From 1980 to 1994, a total of 73 patients were treated at the Russian Research Surgery Institute named after A. L. Polenov for damage to the brachial plexus during birth injury. The authors proposed an original procedure for treating these patients. This involved conservative therapy, surgical intervention on the brachial plexus and correction of the arm locomotor apparatus by orthopedic techniques. The conservative treatment were performed by original methods: namely in combination with hyperbaric oxygenation, low-energy laser exposure of the brachial plexus or by administering cholinesterase agents into the bioenergetic points, followed by electrostimulation of the neuromuscular apparatus. The original conservative treatment led to a significantly improved arm function in 53% of the patients. If the conservative therapy failed, obstacles to the restoring the conduction of the brachial plexus were eliminated via operations (neurolysis, suture, autoplasty, reinnervation). The operation gave the benefit to 74% in whom conservative therapy turned out to be ineffective. If surgical recovery of the brachial plexus failed, arm locomotor intervention was applied.