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Biomedical subjects

E G Pedachenko

Publications and source records attributed to E G Pedachenko.

At least 19 recordsLinked to original sources
PubMed1992

[Differential treatment of focal traumatic brain injury].

On the basis of observation of 65 patients with focal traumatic injury to the brain (hematoma of mater encephali was noted in 24, intracerebral--in 27, a focus of type III brain contusion--in 24, type IV--in 11, multiple hematomas and foci on contusion-crush--in 21), the criteria for their non-surgical treatment have been substantiated. Choice of a method for the treatment depends on the sizes of a hematoma, focus of contusion-crush, location of an injury, degree of its influence on the brain structures (deformation, shift), value of intracerebral pressure, dynamics of the clinico-roentgenologic symptoms.

Adolescent↗
PubMed1990

[Clinical characteristics of repeated cranio-cerebral injury].

The clinical manifestations of repeated craniocerebral injury indicate that repeated brain injury is a graver form of traumatic disease of the brain. As compared to the primary injury, patients with repeated craniocerebral injury manifest more pronounced general cerebral, focal hemispheric symptomatology. In such patients, stem symptoms are also encountered more often. Analysis of 163 cases has demonstrated that the clinical manifestations of repeated craniocerebral injury depend on the gravity of the primary and repeated brain injury, age of the victims and by the rate of repeated injuries.

Adolescent↗
PubMed1990

[Clinical aspects, diagnosis and treatment of cranio-thoracic injuries in patients of different age].

The comparative analysis of the clinical manifestations and informative value of the adjuvant methods of investigation in 125 patients with ++cranio-thoracic injuries and 53 patients with isolated craniocerebral trauma was carried out. This permitted to define more precisely the possibilities of the methods of neurosurgical diagnosis and find the optimal methods for the treatment of patients of different age with ++cranio-thoracic injuries.

Adult↗
PubMed1990

[The clinical manifestations of epidural hematomas in the anterior cranial fossa].

Epidural hematomas of the anterior cranial fossa are a relatively rare localization of intracranial hemorrhage. Hematomas of this localization show a peculiar course and clinical manifestation. By the character of clinical manifestations, course of the injury, results of surgical treatment two groups of patients were distinguished: patients with isolated hematomas of the frontal region characterized by a paucity of clinical manifestations and patients with epidural hematomas of the frontal region associated with other intracranial lesions and are characterized by a grave course and high lethality.

Adolescent↗
PubMed1989

[Features of mild repeated cranio-cerebral injuries].

An analysis of 97 cases indicates that the clinical manifestations of mild repeated head injuries do not reflect the real severity of the traumatic brain disease which determines the necessity of complex clinico-instrumental examination of these patients. Objective clinical and instrumental methods suggest that complete cure does not occur in mild repeated head injury in patients of all age groups.

Brain Injuries↗
PubMed1989

[Prevention of intracranial hemorrhage in the postoperative period in severe cranio-cerebral trauma].

An analysis of 463 patients operated upon for severe cranio-cerebral traumas has shown that one of the main factors improving results of treatment is using the methods of neurosurgical prophylactics of intracranial hemorrhages in the postoperative period. A considerably less incidence of intracranial hemorrhages can be achieved by using the inflow-outflow dialysis system, removing the crushed brain substance, suturing the dura mater to the periosteum at the borders of the bone defect. The ends of the ligature are taken out onto the skin through the holes in the center of the osseous flap.

Brain Injuries↗
PubMedDate not supplied

[Multiple traumatic intracranial hematomas].

An analysis of 133 cases furnished a background to the study of features specific for the clinical course, symptomatology, diagnosis and surgical treatment of patients with multiple traumatic intracranial hematomas. The available clinical material was scrutinized in 3 groups of cases under observation (with "floor-wise", bilateral and "neighbouring" multiple intracranial hematomas) by using a complex set of up-to-date auxilliary diagnostic methods of investigation (EEG, echoencephalography, serial angiography, etc). The results of the surgical treatment were studied depending upon the specificity marking the clinical evolution of the disease, as well as upon the method and technique of the operative intervention.

Brain Injuries↗
PubMedDate not supplied

[The characteristics of craniocerebral trauma in diffuse toxic goiter].

The specific features of craniocerebral trauma in diffuse toxic goiter were studied from analysis of 34 cases. The craniocerebral trauma aggravated the course of diffuse toxic goiter with the development of thyreotoxic crises in the first days after the trauma in one of five patients. The therapeutic tactics in thyreotoxic crisis and the preoperative and postoperative management of patients are discussed.

Adult↗
PubMedDate not supplied

[The characteristics of closed craniocerebral trauma in older persons].

It is shown that in the recent 2 decades the incidence of craniocerebral trauma increased from 4.8 to 7.2% among old-aged individuals and from 53 to 72% in the group of patients over 60. The dynamics of changes in the clinical course of mild craniocerebral trauma in 21% of old-aged patients were marked by secondary acute cerebral circulatory disorders which often led to a fatal outcome. Mortality rate in craniocerebral trauma at old age was 52.3%.

Aged↗
PubMedDate not supplied

[The use of myelopid in the combined treatment of infectious-inflammatory complications in the postoperative period in neuro-oncology patients].

Clinical observations over 48 neurosurgical patients with infectious inflammatory complications and study of their immune status showed that a course of immunocorrective therapy with myelopid produces a favourable clinical effect and normalizes the patient's immune status. Myelopid causes the best normalizing effect in patients with nontumorous pathology of the central nervous system and in extracerebral neoplasms.

Activins↗
PubMedDate not supplied

[The pathogenetic substantiation of the periods of traumatic brain disease].

Advances in the study of the molecular mechanisms of the pathogenesis of closed craniocerebral trauma (CCCT) which was conducted on an experimental model, a clinical equivalent of CCCT, allow one to form a new view of the course of traumatic disease and its division into periods. The data obtained provide evidence that increase of the pathological process in the posttraumatic period is of a skipping and cascade character. The existence of such breaks makes it possible to distinguish periods with consideration for the pathogenetic essence of the pathological changes. 1. The period of intensified metabolic processes, "conflagration of metabolism". 2. The period of development of energy deficit in the nerve tissue. 3. The period of development of cell intoxication processes and secondary structural changes. 4. The period of formation of posttraumatic homeostasis (a) in the regimen of stable homeostasis, (b) in the regimen of stress and subsequent exhaustion of the activity of adaptation systems with the formation of late-term progressive sequelae.

Brain↗