PubMed Health⌕ Search

Biomedical subjects

E G Volkova

Publications and source records attributed to E G Volkova.

14 recordsLinked to original sources
PubMed2005

[Clinical genetic determinants of carbohydrate metabolism disturbances in patients with hypertension and excessive weight].

AIM: To elucidate associations of polymorphic markers of PPAR, PPARG2, IRS1, IRS2 genes with disturbances of carbohydrate metabolism in patients with hypertension and excessive weight. MATERIAL: Patients (n=145, 53 men and 92 women, age 40-75 years) with untreated stage 1 hypertension (systolic BP 140-159 and diastolic BP <100 mm Hg) and excessive weight or obesity (body mass index >27 kg/m(2)) were divided into 2 groups: with (group 1, n=124) and without (group II, n=21) disturbances of carbohydrate metabolism. Group I comprised patients with insulin resistance, abnormal fasting blood glucose or glucose tolerance, type 2 diabetes. Results of oral glucose tolerance test were normal in 25 and abnormal in 99 of these patients. RESULTS: Carriers of Pro allele compared with carriers of Ala allele of PPARG2 gene had higher frequency of insulin resistance. No association was found between insulin resistance and alleles and genotypes of PPAR, IRS1, and IRS2 genes. There was an association between diastolic BP and polymorphic markers Pro12Ala of PPARG2 gene and C24313G of PPARA gene. Carriers of C allele of PPARA gene and Ala allele of PPARG2 gene had higher diastolic BP. No association was found between systolic BP and alleles and genotypes of polymorphic markers of PPARG2 and PPARA genes.

Adult↗
PubMed2004

[Dependence of nitric oxide level in blood on the degree of damage in coronary vessels in women younger than 55 years with ischemic heart disease].

AIM: To estimate content of nitric oxide (NO) metabolites in women under 55 years with reference to affection of coronary vessels as shown by coronaroangiography (CAG). MATERIAL AND METHODS: A case-control study included 32 women under 55 years of age with verified coronary heart disease (CHD) and matched controls. The blood of the examinees was tested for NO metabolites--nitrites and nitrates--according to N. E. Emchenko technique. RESULTS: Subnormal levels of nitrites and nitrates were found both in angina pectoris and myocardial infarction, in unaffected coronary vessels as well. In atherosclerotic coronary vessels NO metabolites' concentrations were the lowest. A significant negative correlation was found between the magnitude of nitrates reduction and the number of atherosclerosis-affected coronary vessels. CONCLUSION: Women under 55 years of age suffering from IHD (any type of coronary affection) had significantly lowered blood levels of NO metabolites compared to healthy women.

Adult↗
PubMed2002

[The role of an overall coronary bed affection in heart remodeling in patients with stenocardia and arterial hypertension].

AIM: To study a possible role of coronary circulation condition in remodeling heart in ischemic heart disease (IHD) patients with hypertension or without it. MATERIAL AND METHODS: The examination (veloergometry, echo-CG and Doppler echocardiography, selective coronaroangiography and left ventriculography) covered 45 hypertensive men with angina of effort functional class III and 69 normotensive patients. Mean age of the patients was 51.8 +/- 1.2 years, duration of the angina 3 to 10 years. RESULTS: Correlation analysis of the data on hypertensive examinees discovered a direct correlation between proportional overall lesion of the coronary arteries, myocardial mass index and left ventricular (LV) index of systolic sphericity, between the sphericity index and myocardial mass index. An inverse correlation--with LV ejection fraction. CONCLUSION: In anginal patients, coronary circulation is an independent factor influencing LV remodeling. With progression of coronary failure remodeling intensifies. In patients with angina arterial hypertension contributes to the same degree to an increase in the personage of overall affection of the coronary bed, LV systolic sphericity index and index of its myocardial mass, forms an integral, global risk of heart remodelling and, later, heart failure.

Angina Pectoris↗
PubMed1999

[Coronary artery function and myocardial perfusion in patients with ischemic heart disease isolated and in combination with arterial hypertension].

AIM: To characterize coronary arteries and myocardial perfusion in isolated ischemic heart disease (IHD) and IHD combined with blood hypertension (BH). MATERIALS AND METHODS: 20 patients with isolated IHD and 25 patients with combined IHD have undergone coronarography, scintigraphy of the myocardium with Tc-99m, echocardiography. RESULTS: In the combined IHD, overall involvement of the heart arteries appeared less than in isolated IHD (33.40 +/- 7.07% versus 41.40 +/- 8.9%). In the combined IHD and left ventricular hypertrophy (LVH) overall involvement of the heart arteries was less while occurrence of perfusion disorders higher than in the absence of LVH (35.98 +/- 4.73% vs 47.21 +/- 5.91%, and 33.7 vs 25.0%, respectively). Defects in the myocardial perfusion both in right and left coronary artery, isolated and combined IHD were of the same type location. CONCLUSION: Disturbed myocardial perfusion is an essential factor in the onset of coronary insufficiency.

Adult↗
PubMed1998

[Lipid peroxidation processes in chronic bronchitis].

AIM: Comparison of the levels of lipid peroxidation (LPO) products in condensate of the exhaled air (CEA) and in the biopsy samples from the inflammation focus. MATERIALS AND METHODS: Extraction spectrophotometry was used to measure LPO products in CEA and biopsies from 30 males aged 30-60 years suffering from chronic bronchitis and 30 healthy controls of the same age. RESULTS: There was activation of local accumulation of isopropanol-soluble LPO products in the bronchopulmonary system accompanied by lowered content of lipoperoxides and high antioxidant activity in CEA. CONCLUSION: Chronic bronchitis is characterized by multidirectional shifts in LPO in the inflammation focus and CEA.

Adult↗
PubMed1990

[Diagnostic potential of the first ECG derivative in assessing the coronary artery status of patients with ischemic heart disease].

The results of the maximal rate of heart ventricle activation (HVA) determined according to the ECG readings and its first derivative were compared in 38 patients suffering from coronary disease (CD) with the coronarography data. 54 healthy men without the clinical and bicycle ergometry signs of CD were examined as control. In patients with angina pectoris, postinfarction cardiosclerosis and acute myocardial infarction, there was a significant decrease of HVA. As the rate of the degree of coronary artery stenosis increased, there was a progressive reduction of the rate of HVA.

Adult↗
PubMed1989

[Intravenous use of low-energy helium-neon laser irradiation in unstable angina].

The effects of low-energy He/Ne laser on some functional characteristics of cardiac activity have been examined in 90 patients with unstable angina pectoris. Altogether 618 sessions of venous blood irradiation have been carried out. A random-sample reference group consisted of 25 patients. Antianginal effect has been assessed by the number of anginal attacks and by the number of daily nitroglycerin tablets. Exercise tolerance has been examined by paired bicycle ergometry; the ventricular rate activation parameters have been examined by the ECG technique and its first derivative. The data evidence a true antianginal clinical effect of intravenous laser therapy, increase of exercise tolerance in respect of both the total exercise performed and the time increment, and an essential acceleration of the ventricular activation in the patients with unstable angina.

Adult↗