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Biomedical subjects

E G Zimmerman

Publications and source records attributed to E G Zimmerman.

17 recordsLinked to original sources
PubMed1984

Autistic children who become schizophrenic.

Infantile autism and schizophrenia have been regarded as unrelated and distinct disorders. There is, however, some evidence in the literature that supports a relationship between the two disorders in that there may be a subgroup of autistic children in whom schizophrenia develops. The diagnostic criteria used in the literature to describe infantile autism and schizophrenia in childhood has not been uniform. The three cases in this report, diagnosed on the basis of current criteria and detailed clinical descriptions, clearly point to an initial diagnosis of infantile autism followed by the development of schizophrenia.

Adolescent↗
PubMed1983

Measurement of delta 9-tetrahydrocannabinol (THC) in whole blood samples from impaired motorists.

The major psychoactive cannabinoid in marihuana, delta 9-tetrahydrocannabinol (THC) was measured in 1792 randomly selected blood specimens from erratic motorists arrested for impairment who submitted to blood alcohol sampling. Of these specimens, 14.4% were positive for THC (greater than or equal to 5.5 ng/mL). In those erratic driver specimens negative for alcohol THC positives rose to 23%. Drivers who used marihuana covered a broad age range. Aliquots of hemolyzed blood (10 microL) were analyzed by a sensitive radioimmunoassay (RIA) not requiring extraction. RIA accuracy and specificity were validated by gas liquid chromatography/mass spectroscopy (GLC/MS) split pair analysis (correlation coefficient = 0.93). This initial experience should facilitate and amplify a program designed to set forth the epidemiology of marihuana use in motorists and possible behavioral correlates.

Adolescent↗
PubMed1976

Hybridization in the Mexican and 13-lined ground squirrels, Spermophilus mexicanus and Spermophilus tridecemlineatus.

Evidence of hybridization between the ground squirrels, Spermophilus tridecemlineatus and S. mexicanus is presented on the basis of chromosomal and protein data. The hybrids produced appear to be completely interfertile. Based on the evidence of hybridization and the recent reestablishment of contact between these two species, they are considered to be semispecies.

Animals↗
PubMed1976

Hemoglobin polymorphism in the encinal mouse, Peromyscus pectoralis.

Horizontal starch gel electrophoresis revealed five hemoglobin phenotypes in natural populations of the encinal mouse, Peromyscus pectoralis, from northeastern Mexico. Populations of the encinal mouse from Texas, Oklahoma, and northwestern and north central Mexico were monomorphic for multiple-band phenotypes. Analysis of the hemoglobin polymorphism indicates that two loci control this variation.

Animals↗
PubMedDate not supplied

A rapid procedure for isolating mitochondrial DNA.

A technique for the rapid isolation of mitochondrial DNA (mtDNA) from animal tissues is described that eliminates the time-consuming separation of nuclear and mtDNAs using cesium chloride gradient ultracentrifugation. The procedure utilizes digestion of the nuclear DNA with DNase, after which lysis of mitochondria and subsequent extraction of proteins results in relatively pure mtDNA. Up to 5 micrograms of mtDNA per gram of liver tissue resulted, a suitable yield for five digests with restriction enzymes and staining with ethidium bromide.

Animals↗
PubMedDate not supplied

Microcomputer-assisted open field measures of rats given ethanol on postnatal days 1-8.

This study examined direct effects of postnatally administered ethanol upon growth and adult open field behaviors in male rats. Charles Rivers CD albino rats (13 litters) were used in 5 groups; ethanol, Sustagen, pair-fed, handled, or unhandled. Experimental animals were intragastrically fed ethanol (Sustagen [Mead Johnson] vehicle) twice daily, comparable volumes isocaloric Sustagen, handled or left unhandled. Ethanol doses on postnatal days 1-8, respectively, were: 1, 2, 3, 4, 4, 3, 2, 1 g/kg. Ethanol-pups ceased weight gains at 4 g/kg; a handled pup, kept with a nonlactating female until its body weight matched its ethanol littermate, became a pair-fed control. Group body weights did not differ from day 21 throughout the experiment, day 154. Open field testing (day 120-124) used microcomputer programs to record event times and frequencies. Ethanol-treated rats had lower activity and longer start latencies (p less than 0.05) but did not differ on other computer-timed measures. Unhandled animals displayed some differences. When underfeeding effects are eliminated, ethanol (up to 4 g/kg) given on postnatal days 1-8 produced open field activity changes that persisted until day 120.

Animals↗