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Biomedical subjects

E Güney

Publications and source records attributed to E Güney.

13 recordsLinked to original sources
PubMed2003

Is the effect of fine-needle aspiration biopsy on the thyroid nodule volume important to evaluate the effectiveness of suppression therapy?

Fine-needle aspiration biopsy (FNAB) is recommended for the initial evaluation of thyroid nodule. If a benign cytology is obtained, suppression therapy with levothyroxine is the first choice in the management of nodular goiter with a follow-up of nodule size with ultrasonography, but the effects of FNAB have not been taken into consideration in this approach. We aimed at evaluating the effect of FNAB on thyroid volume and other ultrasonographic dimensions by measurement of these parameters before and immediately after the procedure, and in later periods, and to clarify the necessity of regarding the effects of FNAB on thyroid. Forty-six patients (34 females, 12 males; mean age: 36.3+/-10.7 yr) with solitary thyroid nodules were included in the study. The nodules were solid in ultrasonography, thyroid function tests were normal and results of FNAB were found as benign cytology. Thyroid hormone suppression therapy was not initiated. Ultrasonographic measurements were made before FNAB, repeated immediately after FNAB, and 1 month and 6 months later. There were no statistically significant changes in the mean thyroid nodule volume, nodule area and circumference of patients before, immediately after FNAB, 1 month and 6 months later. Size differences and individual variability at each time period were analyzed. These parameters changed by more than 10% in a great majority (69.5-78.2%) of patients, and more than 50% change was observed in 17.3-26.0% of patients. Changes in thyroid dimensions were bi-directional, both increment and decrement being noticed. It was thought that this is the reason why there was no significant change in mean nodule volume, area and circumference. Evaluating the difference in nodule volume according to ultrasonographic parameters obtained before FNAB may be misleading because of the individual change in these parameters with FNAB. It may be useful to evaluate the nodule size and volume closely after FNAB to make a true correspondence of these parameters in the long term.

Adult↗
PubMed1999

Otorhinolaryngological aspects of Xeroderma pigmentosum.

OBJECTIVE: to evaluate the probable presence of otorhinolaryngological pathology accompanied by head and neck region skin findings in patients with Xeroderma pigmentosum. METHODS: a total of 19 patients with Xeroderma pigmentosum were investigated for otorhinolaryngological findings. The patients gave their anamnesis and underwent physical examination, audiological tests and endoscopic examination. RESULTS: various malignancies developed in 14 patients on the sun-exposed areas of the head and neck region. Multiple malignancies were found in six of them. There was no other pathological condition secondary to this rare clinical entity. CONCLUSION: Xeroderma pigmentosum causes skin lesions. Some otolaryngological findings such as rhinitis, sinusitis etc. were thought to be coincidental.

Adolescent↗
PubMed1999

Management of N0 neck in T1-T2 unilateral supraglottic cancer.

Early-stage supraglottic cancers (stage I and II) are treated with several different programs. Previously reported data have led us to design a therapeutic protocol in treatment of patients with early-stage squamous cell carcinoma of the supraglottic larynx. From 1991 to 1996, 39 patients with unilateral supraglottic carcinoma were treated according to this protocol. All patients underwent unilateral functional neck dissection and resection of the primary carcinoma in an en bloc fashion. Histopathologic studies showed that 9 (23%) of them had positive nodes, and they received planned adjuvant radiotherapy. None of the 30 patients with histopathologically NO necks received either adjuvant irradiation or contralateral neck dissection. The mean follow-up period was 34 months. All patients are alive, and none have developed any recurrence in either dissected or undissected sides of the neck. This treatment policy seems satisfactory and will avoid unnecessary therapeutic interventions. Routine bilateral neck dissection may not be necessary in the surgical treatment of all supraglottic laryngeal cancers.

Aged↗
PubMed1998

Value of thallium-201 scintigraphy for primary tumour detection in patients with malignant neck masses.

The aim of this study was to assess the contribution of thallium-201 scintigraphy to primary tumour detection in patients with malignant neck masses and to evaluate its sensitivity and specificity. A total of 30 patients with histopathologically proven malignant tumours were included in the study. The sensitivity, specificity and accuracy of 201Tl scintigraphy were found to be 54%, 75% and 57% respectively. These results suggest that 201Tl scintigraphy has a limited value in the detection of the primary tumour in patients with malignant masses of the neck.

Female↗
PubMed1998

Functional neck dissection: cure and functional results.

In this study, the cure and functional results of 133 functional neck dissections performed between 1992-1997 in Erciyes University Medical Faculty were evaluated. The overall recurrence rate was three per cent. This rate was 1.4 per cent for elective functional neck dissections and five per cent for curative functional neck dissections. Electromyographic studies showed that there was severe neurogenic deficit in the trapezius muscle of seven patients (12.5 per cent), and in the sternocleidomastoid muscle of 12 patients (21.4 per cent) among 56 randomly selected patients. In all cases, the flow rate and diameter of the internal jugular vein was found to be normal by Doppler ultrasonography. The results of this study showed that functional neck dissection is a reliable technique for obtaining a high cure rate and functional results.

Adult↗
PubMed1998

201Tl imaging for differentiating between malignant and benign neck masses.

The aim of this study was to assess the ability of 201Tl scintigraphy to differentiate between malignant and benign neck masses. Fifty-eight patients with neck masses, whose diagnoses were confirmed by histological examination, were examined. The sensitivity, specificity and accuracy of 201Tl scintigraphy were 80%, 96% and 88% respectively; when salivary gland masses were excluded, these values were 87%, 95% and 91% respectively. Our results suggest that 201Tl scintigraphy is highly reliable in determining the malignancy of neck masses, especially when salivary gland masses are excluded.

Adolescent↗
PubMed1998

Total lymphocyte and T lymphocyte subpopulation levels in head and neck squamous cell carcinomas.

This study was performed on 72 patients with head and neck squamous cell carcinoma. Total lymphocyte, natural killer cell and total lymphocyte subpopulation levels in peripheral blood were determined and the correlation of these levels with TNM and Histopathologic Malignancy Grading (HMG) systems were investigated. TNM and HMG systems, which are two important prognostic indicators, were significantly correlated whereas total lymphocyte, natural killer cell and total lymphocyte subpopulation levels in peripheral blood had no correlation with TNM and HMG scores.

Carcinoma, Squamous Cell↗
PubMed1994

Bacteriology of chronic suppurative otitis media.

Aspiration of exudate through an open perforation was performed in 183 patients with chronic otitis media. The pus was cultured aerobically and anaerobically. Aerobes only were isolated from 71 patients (39%); 20 patients (11%) had only anaerobes; and 91 patients (50%) had both aerobes and anaerobes. Only 1 specimen had no growth. There were 259 aerobic isolates. Pseudomonas aeruginosa was recovered from 68 patients. Other aerobes commonly recovered included Staphylococcus aureus and Klebsiella pneumoniae. There were 178 anaerobic isolates. Only anaerobic gram-positive cocci were isolated in 20 instances. Sixty-three Bacteroides isolates were recovered, including 12 Bacteroides fragilis group and 21 Bacteroides melaninogenicus.

Adolescent↗
PubMed1993

Ultrasonography in laryngeal cancers.

Endolaryngeal spread of laryngeal malignant tumours is usually determined by conventional endoscopy; however, it can not measure the outward extension of the tumour. As an alternative method for assessing the extension of a tumour and detecting metastatic lymph nodes, we have introduced high-resolution ultrasonography (US) in 34 patients with laryngeal epidermoid carcinoma. The ultrasonographic results were compared with the clinical, operative and histological findings. The ultrasonography revealed malignant extensions in the thyroid cartilage in nine cases, in the carotid artery in four cases, and in the thyroid gland in five cases. These were confirmed by surgical and histopathological examinations. Six patients out of the 34 were subclinical cases, who had metastatic lymph nodes, which were diagnosed by US only. In this study US had a sensitivity of 94.44 per cent and a specificity of 93.75 per cent. The sensitivity and specificity of palpation of the cervical lymph nodes were 66.66 per cent and 87.55 per cent respectively. It may be concluded that high-resolution real-time US is a sensitive, simple and inexpensive method for evaluating laryngeal cancers and subclinical cervical lymph node metastasis.

Adult↗