[Epilepsy as a late sequela of therapy in acute lymphoblastic leukosis--case report].
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Biomedical subjects
Publications and source records attributed to E Gebauer.
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In order to evaluate the specificity of hemostatic mechanism in premature Infants, the following examinations of coagulation and fibrinolytic parameters have been done: platelet number, concentrations of fibrinogen prothrombin, factors V, VII X, X, VIII, IX and XIII, antithrombin III, plasminogen, euglobulin lysis time, fibrin degradation products, alpha-1 antiplasmin and alpha-2 macroglobulin. The examinations have been done in the whole of 18 premature infants of both sexes. The obtained results show that lowered level of coagulant activity was not exclusively the consequence of low activity of vitamin-K dependent factors, but the result of more complex disorders partly connected with the transient reduction of factors VIII, XIII and fibrinogen. The total fibrinolytic activity, in the meantime, was of the normal intensivity. The established disorder of coagulation-fibrinolytic balance probably represents the certain contributing factor in more frequent occurrence of haemorrhagic syndrome in premature infants.
In the group of 391 examined children in the third trimester of their life the mean values have been established for the principal hematological parameters of the red family (hemoglobin = 11,52 +/- 0,87 g/100 ml, hematocrit = 36,12 +/- +/- 3,12%), as well as anemia frequency which is 29,06% if the lower lewel of the normal hemoglobin value is 11 g/100 ml for that period of infants' life. These investigations have been stated statistically significant lower hemoglobin values and a higher anemia frequency in group of infants with low weight at birth (17,5 of anemic children were prematurely born, and 55,38% weighted under 3.250 g. at their birth), than in the group of infants with non-adequate nutrition, and among infants with frequent infections. The prophylactic measures were suggested to decrease frequency of sideropenic anemia - the most widely spread type of anemia in early life of children.
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