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Biomedical subjects

E Gerling

Publications and source records attributed to E Gerling.

3 recordsLinked to original sources

Age-dependent variations in the distribution of methaqualone in rat.

Rats at 1, 4, 8, 12, 20 and 60 postnatal days received orally 5 mg/kg 14C-methaqualone (MTQ) and were sacrificed at 0.5, 1.5 and 6 h. Several tissues were analyzed for unchanged MTQ. In most cases, concentrations reached peak levels at 1.5 h. Highest concentrations were found in the liver followed by the lung, spleen, heart, kidney, eye, and brain. Levels of MTQ were higher in all organs of 1- to 12-day-old rats at all time intervals than the corresponding organs of 20- and 60-day-old rats, apparently resulting from initial higher accumulation and slower rate of disappearance. The 1.5-hour brain:plasma concentration ratio in 8-day-old rats was 0.82 and progressively declined to 0.27 in 60-day-old rats; a similar trend with respect to changes in concentration ratio also occurred for the eye, spleen, kidney, and heart. The fact that the age-related reduction in tissue:plasma concentration ratios occurred in several tissues including brain suggests generalized decreases in tissue accumulation of MTQ. The reduction in brain:plasma concentration ratios, therefore, cannot be ascribed to the blood-brain barrier which develops progressively with the advancing age.

Aging

The effects of social sex-role stereotypes and sexual orientation on psychotherapeutic outcomes.

This paper examines the relationship of biological sex, social sex-role stereotypes, and sexual orientation of client and the therapist to psychotherapeutic outcomes. It was hypothesized that analogus biological sex, departures in social sex-role, and sexual orientation of client and therapist would have positive effects on psychotherapeutic outcomes. Twenty-four clients and 16 therapist, including five client-therapist pairs, were interviewed on how issues of social sex-role stereotyping and sexual orientation arose and were dealt with in therapy. The results indicated (a) a trend toward more positive outcomes when client and therapist were of the same sex, and (b) that similarity of sexual orientation of client and therapist is related to positive psychotherapeutic outcomes. The results for deparature from social sex-role stereotypes were inconclusive.

Adolescent