Interview with Elizabeth Gilmore. Interview by Ina May Gaskin.
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Attitude to Health↗
Biomedical subjects
E Gilmore
Publications and source records attributed to E Gilmore.
A multiyear study of blood cholinesterase activity in urban pesticide applicators.
This article is a review of blood cholinesterase activity in a cohort of urban pesticide applicators ranging from 1680 to over 3800 workers. During the period 1981-1991, 208, 788 blood samples were taken for measurement of cholinesterase activity with an average of 6 samples per year from each worker. A total of 150 workers or 0.44% of the cohort was removed from exposure to cholinesterase-inhibiting insecticides because of decreased cholinesterase activity. No worker required treatment for signs of cholinesterase inhibition.
Adult↗
Detection of the PTC/retTPC oncogene in human thyroid cancers.
We have investigated the PTC/retTPC oncogene, an activated form of ret proto-oncogene with a specific rearrangement, in thyroid malignancies. Southern analysis was used to screen 36 thyroid papillary carcinomas (PC), 22 normal thyroid tissues from glands with PC elsewhere, three follicular carcinomas, eight follicular adenomas and 30 other non-malignant thyroids. Rearrangements were detected in four PCs (11%) using probes derived from the ret proto-oncogene. Genomic breakpoints from a PC and a PC cell line (TPC-1) were cloned and sequenced. The rearrangement points of ret proto-oncogene were found in the intron between the exon for the transmembrane domain and the first exon for the tyrosine kinase domain. Furthermore, the PTC/retTPC chimeric transcripts were detected in two PCs with the rearrangement by reverse transcription polymerase chain reaction. Distant metastases were present in 50% (2/4) of PCs with the rearrangement, but in only two out of 32 PCs without a detectable rearrangement (P = 0.05, Fisher exact test). Our study suggests that the rearrangement of the ret proto-oncogene may be involved in the development of distant metastases in patients with papillary thyroid carcinomas. However, a larger clinical study will be required to verify this observation.
Adolescent↗
Insulin disappearance rate in pregnant and non-pregnant women, and in non-pregnant women given GHRIH.
The half-life of injected monocomponent insulin, as judged by radioimmunoassay, has been found to be 3-3 1/2 min in a group of healthy women. This value is unaffected by pregnancy. Tests were repeated in non-pregnant women during an infusion of GHRIH to ensure that endogenous insulin secretion was suppressed by the dose of insulin given. Similar values were obtained.
Blood Glucose↗
Treatment of essential hypertension with combined vasodilation and beta-adrenergic blockade.
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Administration, Oral↗
Treatment of essential hypertension with a new vasodilator in combination with beta-adrenergic blockade.
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Adrenergic alpha-Antagonists↗
Vivamos! A summer program for teenage parents.
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Adolescent↗