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E Globocnik

Publications and source records attributed to E Globocnik.

4 recordsLinked to original sources
PubMed1980

Bone sarcomas in 239Pu-treated mice.

Female ICR mice were injected with a monomeric form of 239Pu (180.1 kBq/kg) at the age of 10 weeks and during the long-term contamination the incidence of bone sarcomas was studied. Average survival of 100 control mice was 545 +/- 14 days, the 100 plutonium-given mice survived 420 +/- 10 d and 50 sarcoma-bearing animals 456 +/- 11 days. Most of the 61 induced sarcomas were located in the spine (70%) and in trabecular parts of the other bones. Among these 61 tumors there were 55 osteoblastic osteosarcomas, 4 immature undifferentiated sarcomas and 2 angiosarcomas. In 6 tumor-bearing mice metastases were observed in lungs, liver, intracranial cavity and in mediastinal lymph nodes. Among control mice only one osteogenic mandibular sarcoma was verified. The osteosarcoma incidence was evaluated with respect to the retained activity and cumulative average skeletal dose. The results were discussed and compared with data published by others.

Animals↗
PubMed1978

[Histological examination of changes due to aging in the femur compacta of laboratory and house mice].

The age changes in the histological structure of the femur corticalis in ICR laboratory mice (from 20 to 300 days) and in house mice (from 50 to 520 days) were studied. In both forms of mice the circumferential lamellae prevailed, with increased age they are substitued by secondary but mainly primary Haversian systems and the interstitial systems of vartious shape. Certain differences in the construction of the femur corticalis, were found in both species of mice; from among the latter the mouse is more suitable for the demonstration of age changes.

Aging↗