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Biomedical subjects

E Gloor

Publications and source records attributed to E Gloor.

At least 19 recordsLinked to original sources
PubMed1991

[Malacoplakia of the vagina. Cytological, histological and ultrastructural study of a case].

A case of vaginal malakoplakia is reported in a 65 year old patient receiving prednisone for fifteen months for the treatment of collagen colitis. The macroscopic and microscopic appearance, cytological examination of the vaginal smear and ultrastructural examination were typical of malakoplakia. To our knowledge, this is the seventh detailed case of vaginal malakoplakia and the twenty-sixth case of malakoplakia of the female genital tract.

Aged↗
PubMed1988

[Necrotic oophoritis due to cytomegalovirus].

In a 54-year-old woman with malignant lymphoma, cytomegalovirus oophoritis was disclosed at autopsy. The virus, which is recognized by its typical nuclear inclusions, reaches the cortical stroma of the ovaries and causes zones of necrosis there. Its presence is confirmed by ultrastructural and immunohistochemical examination. The real frequency of ovarian involvement is difficult to evaluate since histological examination of ovaries is not routinely performed at autopsy. As far as we know the present case is the seventh detailed observation of cytomegalovirus oophoritis published in the literature.

Cytomegalovirus Infections↗
PubMed1986

Cervical intraepithelial glandular neoplasia (adenocarcinoma in situ and glandular dysplasia). A correlative study of 23 cases with histologic grading, histochemical analysis of mucins, and immunohistochemical determination of the affinity for four lectins.

Twenty-three cases of cervical intraepithelial glandular neoplasia (CIGN)--a term encompassing adenocarcinoma in situ and glandular dysplasia of the uterine cervix--were studied histologically, histochemically for mucins (neutral mucins, sialomucins and sulfomucins), and immunohistochemically for the affinity of four lectins (WGA, PNA, RCA, UEA). For comparison, six cases of cervical invasive adenocarcinoma and ten cases of cervices without tumor were similarly studied. Criteria for histologic grading of CIGN into three degrees were proposed according to the hyperchromasia and the stratification of nuclei, number of mitoses, and amount of intracellular mucin. Two different types of CIGN were distinguished according to their histological aspect and their mucin pattern: CIGN type A, where the mucin pattern was qualitatively similar to that of normal endocervical mucosa, i.e., neutral mucins, sulfomucins and sialomucins; and CIGN type B, where the glandular cells resembled small intestinal goblet cells and the mucins consisted of neutral mucins and sialomucins with the absence of sulfomucins. Nine cases of CIGN were of type A, 2 of type B, and 12 of both type A and B. Differences in lectin binding existed between normal columnar cells, CIGN, and invasive adenocarcinomas, as well as between CIGN of type A and B. The intensity of the positive immunochemical reaction varied, as well as the type of binded lectin and its localization in the cell. There was a great heterogeneity in the same histologic group from one case to another, and even in the same case from one cell to another.

Adenocarcinoma↗
PubMed1986

[Detectability of glaucomatous visual field defects with the Octopus automatic perimeter. A comparison between program G-1 and programs 31 and 32 and their combinations].

Twenty-three patients between 31 and 76 years of age suffering from either hypertension or glaucoma underwent automatic perimetry with Octopus programs 31 or 32, followed by program G-1. This was done to compare the information content of the latter, new program with that of the former two, long-used in different combinations. Only one eye of any one patient was considered in this study. Using an evaluation program, the G-1 program calculates the so-called "field indices" which help to interpret the results. These field indices are the mean differential light sensitivity threshold (mDLS), the mean defect (MD), the loss variance (LV), and the corrected loss variance (corrected for short-term fluctuations (CLV)). In order to compare programs 31, 32, and their combination 31 + 32, with the field indices of program G-1, the mean DLS was taken from the Delta evaluation program, while the mean defect, the loss variance, and the corrected loss variance were calculated on the basis of programs 31, 32, and the combination of them. The mDLS and mean defect determined with program G-1 were significantly different from those found with programs 31, 32, and the combination of them. On the one hand, this was due to the difference in test patterns, that of G-1 being more centrally weighted; on the other hand, this is indicative of the precision and discrimination capability of Octopus measurements. Calculation of loss variance and corrected loss variance reveals no significant difference between the examination methods as regards these field indices, that is, between G-1 and 31, 32, or 31 + 32.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1986

[Early diagnosis of premalignant and malignant lesions of the endometrium. Evaluation of a device for collecting intrauterine samples (the Inocurette) compared with exploratory curettage].

Screening methods for detecting more accurately carcinoma of the endometrium is becoming increasingly important because of the rising incidence of the condition. Inocurette has recently been invented to combine a scraping action with suction. This study investigates 385 patients who were admitted for diagnostic curettage or hysterectomy to which were added a series of 120 patients who were examined as out patients. Inocurette has a sensitivity of 86% and a specificity of 99%. It therefore can be considered as a reliable method of screening for the limits within which fractional diagnostic curettage should be used. Marked pain and great difficulty in introducing the apparatus made its use limited in respectively 15% and 14.5% of cases. So, the method is acceptable and useful within these limits. The results could be improved if on the one hand a thinner apparatus could be designed and on the other hand a substance could be found to soften the cervix so that it became easier to introduce the apparatus.

Adenocarcinoma↗
PubMed1985

[Prevalence of infectious diseases at the Vaud University Hospital Center].

The prevalence of infectious diseases at our hospital (Centre hospitalier universitaire vaudois, Lausanne [CHUV], 900 beds) was studied retrospectively over a two years period (1980-1981). The medical diagnosis of 30203 patients recorded in the computerized medical archives, representing 93% of the patients admitted during the period of observation, was reviewed. To assess the reliability of the computerized data, quality control was carried out through detailed analysis of all the histologically proven appendicitis recorded during 1981. 88% of the histologically proven appendicitis were registered in the computer and the diagnosis was specific in 87% of cases. An infectious disease was the primary reason for admission in 12.8% of the patients (3873) during the study period. Altogether, 20.2% of patients presented with an infection during their hospital stay. Because of the retrospective nature of the study it was not possible to determine whether these additional infections were nosocomially acquired. The organ systems most frequently infected were the respiratory tract (28.5% of all infections), the digestive tract (20.5%), the skin and osteoarticular system (16%) and the urogenital tract (11.6%). An infection was the primary reason for admission of 40.2% of the patients hospitalized in the dermatology service, of 19.7% of patients admitted in internal medicine, of 15-17% of the patients admitted in pediatrics, ENT and general surgery, and of 1-2% of the patients admitted in neurosurgery and radiotherapy. These observations highlight the continuing importance of infectious diseases in a modern hospital, in spite of high socio-economic levels, stringent hygiene and epidemiologic measures, and modern antibiotic availability.

Appendicitis↗
PubMed1984

Adenocarcinoma in situ and invasive adenocarcinoma of the uterine cervix. An immunohistologic study with antibodies specific for several epithelial markers.

The distribution of carcinoembryonic antigen (CEA), secretory component (SC), fat globule membrane antigens ( FGMA ), and keratin was determined immunohistochemically in 22 invasive adenocarcinomas of various types and in 9 adenocarcinomas in situ of the uterine cervix. In the invasive adenocarcinomas 77% were positive for CEA, 47% for SC, 89% for keratin, and 77% for FGMA . In adenocarcinomas in situ 67% were positive for CEA, 11% for SC, and 44% for keratin. The location of the markers was variable in the cells, and the cells in a tumor were irregularly positive. For a given histologic type there were several phenotypes. No correlation was found between histologic types of invasive adenocarcinomas and the various phenotypes. It remains to be shown whether a particular phenotype has a particular biological behavior. The detection in the serum of the markers shown in histologic preparations could be useful in the postsurgical monitoring.

Adenocarcinoma↗
PubMed1984

Autoimmune oophoritis.

A 43-year-old para 3 woman presented with a six-year history of progressive oligomenorrhea and hypomenorrhea. A total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed for the suspicion of ovarian cysts. On histologic examination, the ovaries contained lymphocytic and plasma cell infiltrates in relation to the theca interna of growing follicles, to the corpora lutea and to the endocrine hilar cells. The infiltrates increased in density with the follicular maturation and culminated against the corpora lutea. The plasma cell population was polyclonal. No antibodies to ovarian tissue components could be demonstrated in the patient's serum by means of immunohistochemistry; but antibodies to the zona glomerulosa of adrenal cortex were detected by serologic means. Although a rare disease, autoimmune oophoritis must be recognized histologically because it is a cause of ovarian failure and because it indicates that the patient is at risk of developing associated Addison's disease.

Adrenal Cortex↗
PubMed1983

Placental site trophoblastic tumor (trophoblastic pseudotumor) of the uterus with metastases and fatal outcome. Clinical and autopsy observations of a case.

A 41-year-old woman who 5 years earlier had a hysterectomy for a placental site trophoblastic tumor (formerly called trophoblastic pseudotumor) was readmitted to the hospital with pelvic recurrence and multiple lung metastases. Despite an initial decrease in the size of the lung metastases and concomitant lowering of the serum values of human chorionic gonadotropin (beta-HCG) from 2,200 to 40 ng/ml, combined chemotherapy became ineffective. The patient died 4 months later with widespread metastases. The clinical course and the autopsy findings of this case are reported and compared with the two similar cases reported in the literature.

Adult↗
PubMed1981

Trophoblastic pseudotumor of the uterus: clinicopathologic report with immunohistochemical and ultrastructural studies.

The clinicopathologic feature of two cases of trophoblastic pseudotumor of the uterus are presented and compared with previously reported cases. In both cases, cancer was erroneously diagnosed. One patient, 27 years of age when first examined, presented metrorrhagia 10 months after a full-term delivery. The lesion was entirely removed by curettage and was no longer found in the hysterectomy specimen. The patient is alive and well more than 17 years after therapy. The other patient, 36 years of age at the initial examination, presented with metrorrhagia 23 months after a therapeutic abortion. The pseudotumor infiltrated the full thickness of the uterine wall. The patient is alive and well 3 years and 7 months after hysterectomy and radiation therapy. Histologically, the tumor consisted of large cells invading the myometrium in small clusters either as cords or as single cells. There were 2 mitoses/10 HPF of which some were atypical. Tumor cells containing chorionic gonadotropin (hCG) and a pregnancy-specific protein (SP1) were demonstrated immunohistochemically (alpha 2-PAG) and placental lactogen (hPL) in one case. Ultrastructurally, trophoblastic pseudotumor closely resembled cytotrophoblastic cells of the basal plate of the placenta.

Adult↗
PubMed1979

[Elements of the prognosis of invasive epidermoid carcinoma of the cervix. Study in terms of the clinical stage and histologic criteria].

The prognosis in 143 cases of squamous cell carcinoma of the uterine cervix was studied in terms of clinical stage and various histological parameters. The results were compared with those in the world literature. In our series the clinical stage proved to be the most decisive element in the prognosis: the survival rates of stages I to IV were 77.1%, 58.3%, 28.6% and 0% at five years and 65.7%, 51.7%, 20.0% and 0% at ten years. The majority of deaths due to cancer occurred in the first five years after treatment. The prognosis was less favorable when the carcinoma occurred on the cervical stump after subtotal hysterectomy. The authors found Wentz and Reagan's histological classification adopted by the WHO to be difficult if not impossible to apply uniformly without error, due to numerous mixed forms. In addition, it has no statistically significant prognostic value. Among the other parameters considered in this study, only the type of stroma appeared to have some prognostic value. The prognosis was less favorable in tumors with a stroma of the fibrous type.

Carcinoma, Squamous Cell↗
PubMed1979

[Mature benign teratomas with malignant tumors and malignant monodermal ovarian teratomas. Anatomo-clinical presentation of 10 cases].

The clinicopathologic features are presented of 8 malignant neoplasms occurring in adult teratomas, and of 2 malignant monodermal teratomas found in a continuous series of 1029 cases of ovarian adult teratomas. The age of the patients was 44--76 years. The first 8 observations included 6 epidermoid carcinomas, 1 undifferentiated carcinoma and 1 strumal carcinoid. In the epidermoid carcinomas malignancy was recognized peroperatively only in three instances. One tumor had infiltrated the broad ligament on one side and another the urinary bladder. The neoplasm appeared as a mass which thickened the wall of a typical dermoid cyst. Four patients died of the tumor from 3 months to 1 year after operation; one is alive more than 19 years later and one is lost to follow-up. The crucial factor in prognosis is the integrity of the ovarian capsule. The undifferentiated carcinoma, which had infiltrated the pelvic walls, could only be incompletely resected and caused death within 3 1/2 months. The strumal carcinoid was discovered by chance during laparotomy for a far-advanced adenocarcinoma of the pancreas which led to death within 2 months. The two cases of malignant monodermal teratoma comprised 1 thyroid papillary carcinoma and 1 carcinoid. Both patients are alive more than 8 and 5 years after operation. The carcinoid manifested itself by persistant diarrhea which ceased soon after operation and did not recur subsequently.

Adult↗
PubMed1979

[Female genital bilharziasis. 1 case].

In a Swiss woman who had travelled in Africa ovarian and tubal bilharziasis (Schistosoma haematobium) was found by chance during laparotomy. In both sexes genital bilharziasis is nearly always caused by Sch. haematobium and is a complication of bilharziasis of the bladder and intestine. Genital bilharziasis in woman is found principally in the cervix and in the vagina, less commonly on the vulva and in the fallopian tubes and ovaries, and rarely in the body of the uterus.

Egypt↗
PubMed1979

Ovarian sex cord tumor with annular tubules. Clinicopathologic report of two benign and one malignant cases with long follow-ups.

The clinicopathologic features of three new cases of ovarian sex cord tumors with annular tubules are presented, thereby increasing to 23 the number of the published cases in the world literature. These three observations, along with another one which was previously published, were found in the files of the Institute of Pathology of the University of Lausanne from 1939 to 1978. Forty-seven granulosa cell tumors and eight Sertoli and/or Leydig cell tumors of the ovary were found during the same 40-year period. The patients were 48, 64 and 71 years of age. No sign of the Peutz-Jeghers syndrome was noticed in the three patients. All three tumors caused metrorrhagias as a cardinal sign. They were bulky, unilateral and were formed by solid tissue with cystic spaces. Histologically, the most characteristic pattern consisted of simple and complex tubular structures as described by Scully in 1970. Two patients, in which the mitotic indexes of the tumors were lower than 5 mitoses per 10 HPF, died without evidence of a recurrence 36 and 37 years after surgical ablation of the tumor. The third patient, whose neoplasm featured fewer well differentiated tubular structures than the two previous ones and had a mitotic index of over 70 mitoses per 10 HPF, died from massive abdominal recurrence after 5 years and 5 months.

Aged↗
PubMed1979

Müllerian adenosarcoma of the uterus. Clinicopathologic report of five cases.

The clinicopathologic features of five cases of müllerian adenosarcoma of the uterus are presented and are compared with those of previously reported cases. Four tumors were localized in the endometrium; in one case, a cervical or endometrial origin was not clear. The ages of the patients ranged from 53 to 79 years. Two died without clinical evidence of recurrence 19 and 18 years after hysterectomy. One was alive and well 10 years postoperatively and one was lost to follow-up 6 months after therapy. In one case, a first abdominal recurrence was resected 5 years and 9 months after hysterectomy; the patient died of a second abdominal recurrence 18 months later. The tumors were bulky polypoid masses producing metrorrhagia. Histologically, a sarcomatous component was intimately associated with benign epithelium of various müllerian types. The neoplasm was typically organized in papillary fronds and periglandular sarcomatous cuffs. Cystic glands were also a constant feature. Mitoses were generally fewer than 10 per 10 high-power fields, except in one case where they were 44 in a more malignant-appearing area. Adenosarcoma must be differentiated from other müllerian tumors, mainly carcinosarcoma whose prognosis is much less favorable.

Aged↗