Among the 15.998 live births recorded in Upper Austria in the year 1985, a representative malformation rate of 1.79, respectively a representative incidence of 17.94 in 1000 live births is reported. The incidences of characteristic malformations and of single malformations combined in malformation groups are determined. An instrument of investigation, especially developed for and successfully used in this examination in form of an illustrated questionnaire is introduced.

Austria↗

PubMed1982

[Perinatal mortality from 1969 to 1979].

From January 1969 to December 1979 a total number of 26,255 births took place at the Department of Obstetrics and Gynecology of the General Hospital Steyr. During this period the perinatal mortality decreased from 35.7% to 11.2% and the standard perinatal mortality (according to the WHO criteria) from 23.8% to 4.8%. The premature birth rate decreased from 7.4% to 4.4%. The chance of survival for low-birthweight newborns was increased impressively. The factors which account for the improvement of these obstetrical results are analyzed.

Austria↗

PubMed1981

[Gestational trophoblastic emboli as possible cause of an acute respiratory distress syndrome (author's transl)].

In a patient with gestational trophoblastic disease midtrimester abortion was induced by intravenous application of prostaglandin F2 alpha. After evacuation of the uterus the patient developed a severe acute respiratory distress syndrome (ARDS). This syndrome has been described as resulting from trophoblastic emboli, hemorrhage shock, gestational osmotic imbalance or disseminated intravascular coagulation. Also an indirect side effect of prostaglandin has to be discussed. Patients who develop acute pulmonary complications after evacuation of a molar pregnancy appear to be at extremely high risk for persistent trophoblastic disease. The paper details the management and follow-up of this patient.

Abortion, Induced↗

PubMed1980

[Laparoscopic diagnosis of inflammatory adnexal diseases].

Explore the source record for details and available documents.

Endometriosis↗

PubMed1980

[Prevention of infections after cesarean section].

Explore the source record for details and available documents.

Cesarean Section↗

PubMed1979

[Tbual Sterilization (author's transl)].

During the years 1975, 1976 and 1977 2481 tubal sterilizations were performed, either simultaneously with gynaecological operations or Caesarian sections, as an independent operation post partum or by laparoscopy. Unipolar, bipolar or thermocoagulation was used for tubal occlusion. Primary surgical complications occurred in 0.36% of the patients. Until March 31st, 1978 6 women (0.24%) became pregnant after tubal coagulation; so far 2 women have asked for reversal of the operation. From the surgical point of view, on the basis of the basis of these figures, it is a low-risk, dependable (Pearl index 0.13), irreversible method of contraception.

Adult↗

PubMed1976

[Translocation (13; 18) (q22; p 11) and prenatal diagnosis (author's transl)].

A balanced translocation (13; 18) (q 22; p 11) was diagnosed in two generations. Out of 10 pregnancies in these two translocation carriers, mother and daughter, only two phenotypically normal childern were born. One of these, namely the daughter, showed balanced translocation, whilst a normal karyotype was diagnosed prenatally in the second case. The other eight pregnancies ended either in spontaneous abortions, in intrauterine death or in lethal malformations. In the present translocation the formation of unbalanced gametes seems to be enhanced.

Abnormalities, Multiple↗

PubMed1976

[Rejection of a kidney graft after pregnancy and delivery].

Eighteen months after cadaver kidney transplantation a 22-year-old woman was successfully delivered of a healthy female child. Onset of allograft rejection in the third trimenon was followed three weeks after delivery by progressive renal failure and resumption of regular dialysis treatment. Pregnancy risk factors after successful renal transplantation and immunosuppressive therapy are discussed.

Adult↗

PubMed1975

[Comparative morphological investigations of human ovarian follicles and their oocytes (author's transl)].

During gynaecological operations on 27 women aged 20 to 52 years, all visible follicles were punctured and 42 oocytes removed for investigation partly by phase-contrast microscope and partly by semi-thin slides. specimens of the walls of the follicles WERE REMOVED AND EXAMINED HIstologically. Furthermore, the activity of steroid-3 beta-ol dehydrogenase was demonstrated histochemically in 14 cases. Comparative investigations of the walls of the follicles and their oocytes gave the following results: 1. In non-ovulatory tertiary follicles (3 to 12 mm in diameter) with no, or very little luteinization of the theca interna and a granulosa of 3 to 10 cell layers, steroid-3 beta-ol dehydrogenase activity was only found in the theca interna. In 5 out of 23 follicles, the oocytes showed early or advanced signs of degeneration. Thus, atresia of the follicles probably occurs after degeneration of the oocytes. 2. 12 follicles (8 to 30 mm in diameter) showed distinct luteinization of the theca and steroid-3 beta-ol dehydrogenase activity in the theca interna, as well as in the granulosa. 4 of these follicles (all at least 20 mm in diameter) showed oocytes with typical pre-ovulatory changes. In 3 other cases with a similar morphological picture of the follicular wall specimens, the oocytes showed no preovulatory changes. The conclusion is drawn that the functional differentiation of the wall of the follicle induces the preparation of the oocyte for ovulation. On the other hand, 5 similar follicles already had degenerating oocytes. It remains doubtful whether such follicles can reach ovulation. 3. In follicles with early or advanced atresia, the oocytes were completely degenerated.

Adult↗

PubMed1975

[Oocytes morphology of tertiary follicles in women with normal and disturbed ovarian function (author's transl)].

During gynecological operations 2 to 20 mm tertiary ovarian follicles were punctured in 65 women aged from 20 to 50 years. 205 eggcells were obtained. Histological examination of these eggcells revealed the following results: 1. Oocytes of small tertiary follicles are not increasing in size during maturation of the follicle. The average diameter of the ooplasma is 109 mu. The most impressive morphological criterium of imminent ovulation in oocytes from Graafian follicles is a loose cloud of granulosa cells. 2. The puncture of all visible tertiary follicles of both ovaries revealed an average of 6 eggcells in younger women (28 to 40 years), but only 3 eggcells in older women (41 to 53 years). In both groups signs of degeneration were observed in one out of 3 eggcells. In cases of anovulatory cycles and Stein-Leventhal-Syndrom, up to 16 eggcells could be obtained from both ovaries, most of them with signs of degeneration. 3. No differences in the number of eggcells and the number of degenerated oocytes could be found during the different phases of the menstrual cycle. The degeneration of the oocytes can begin at any phase of the cycle. Even in the follicles of the preovulatory phase measuring more then 1 cm in diameter eggcells with signs of degeneration could be found.

Adult↗

PubMed1975

[The post partum administration of quingestanolacetate 0.3 mg as oral contraceptive (author's transl)].

Quingestanolacetate (0.3 mg daily), as from the second week post partum was given to 13 women for a total of 111 therapeutic cycles of 28 days. In addition to clinical follow up, 8 women were subjected to serial pregnanediol determinations in the night urine every other day for a total of 45 cycles. One woman became pregnant in the 5th therapeutic cycle, demonstrating an insufficient contraceptive effect of this minipill. The only major side effect was the occurrence of irregular episodes of bleeding during the first 3 therapeutic cycles. With increasing duration of the administration of this drug, the vaginal bleeding settled down to approximately 7 days per 28 days. When pregnanediol serial determinations were started in the 4th to 6th therapeutic cycle post partum, 6 out of 8 women showed ovulatory cycles. In the two remaining patients ovulatory cycles were observed in the 7th and 10th therapeutic cycle, respectively. Of 45 cycles in which control pregnanediol serial determinations had been undertaken, 11 (25%) were anovulatory, 21 (46%) showed a normal ovulatory excretion pattern and 13 (29%) showed severe luteal insufficiency. An insufficiency of luteal function appears to be partially responsible for the contraceptive effect of this minipill.

Adult↗

PubMed1975

[Detection of sex-chromosome anomalies in newborn infants (author's transl)].

6084 consecutive newborn infants were screened for the purpose of evaluation of the X- and Y-chromatin in the cells of the buccal mucosa to detect sex-chromosome anomalies. An anomaly was discovered in 14 newborn infants (0.23%). Among 3184 male infants 8 cases of Klinefelter's syndrome, 2 cases of XYY syndrome and 1 case of a rare structural anomaly of the Y-chromosome were detected. Among 2900 female infants there was 1 child with Turner's syndrome and 2 children with the Triplo-X syndrome. The following clinical features were frequently observed: low birth weight, small size, dystrophy, signs of dysmaturity and increased maternal age. A gonosomal anomaly should be suspected in all cases presenting these characteristic clinical features and the necessary investigations carried out. By these means X-chromosome aberrations, at least, could be partly diagnosed.

Chromosome Aberrations↗