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Biomedical subjects

E Gregersen

Publications and source records attributed to E Gregersen.

At least 55 records · Page 3Linked to original sources
PubMed1977

Congenital glaucoma before and after the introduction of microsurgery. Results of "macrosurgery" 1943-1963 and of microsurgery (trabeculotomy/ectomy) 1970-1974.

Primary trabeculotomy (in five eyes "converted" to trabeculectomy) normalized the tension in all 21 eyes with congenital glaucoma without associated diseases, (mean postoperative tension 12 mmHg, range 8-20 mm). Re-operation was needed for only one eye. Preoperatively glaucomatous cupping was present in 18 of these 21 eyes. Ten of the 18 eyes with glaucomatous cupping were operated upon before the age of 6 months two before 11 months and the appearance of the disc was normalized in these 12 eyes. Repeated trabeculotomy, -ectomy was without success in three of five operated eyes in patients with congenital glaucoma of several years duration previously treated by "macrosurgery". In patients with associated diseases normal tension was achieved by means of trabeculotomy/-ectomy in two eyes in two Sturge-Weber children with unilateral congenital glaucoma and in both eyes in a child with a chromosomal defect with bilateral congenital glaucoma. Repeated trabeculotomy/ectomy was on the other hand without success in a child with bilateral aniridia with congenital glaucoma and hydrocephalus. Presupposing acute or subacute microsurgery, the present operative results of congenital glaucoma without diseases are far better than those obtained in previous decades by "macrosurgery" which, despite frequent re-operations, effected normalization of the tension in only 61% of the eyes (11 of 26 patients (42%) with bilateral congenital glaucoma without associated diseases and treated by macrosurgery in previous decades were under the Care of the Blind).

Denmark↗
PubMed1977

The distended disc in early stages of congenital glaucoma.

In 12 out of 18 eyes operated upon for congenital glaucoma without associated diseases the preoperative glaucomatous cupping had disappeared at follow-up 2 weeks to 3 months after the operation (trabeculotomy ab externo on 9 eyes and trabeculectomy on 3 eyes). Of the 12 eyes, 10 had had the operation performed before the age of 6 months, in contrast to the group in which glaucomatous cupping of the disc was irreversible where operation had been performed in the age range 6 months--12 years (mean 6 years). The mean postoperative tension value in the 18 eyes was 12 mm (range 8-20) mm) without medication, mean observation time 3 years. It seems likely that during the first phases of congenital glaucoma the disc is distended, i.e. of increased diameter and depth. This form of glaucomatous cupping and the increased diameter of the disc may be due to pressure-conditioned enlargement of the scleral canal and omnidirectional distention of the lamina cribrosa. This distention manifests itself mainly in the central areas of the lamina cribrosa and the disc, and usually disappears when the tension is normalized by surgery during the first phases of the disease.

Child↗
PubMed1976

Extramembranous pregnancy with amniorrhoea.

A case of extramembranous pregnancy is reported. From about the 10th week of pregnancy there was an intermittent loss of liquor amnii, which from about the 25th week, became continuous. The infant was born alive in the 31st week, but died 15 days later because of the respiratory distress syndrome. The placenta was circumvallate with short, thick membranes unable to cover more than a small part of the infant. The course of the pregnancy and the prognosis of the infant are discussed on the base of previous publications. Because of the poor prognosis for the infant it is suggested that interruption of the pregnancy should be considered in early cases of amniorrhoea.

Adult↗
PubMed1975

The value of an ophthalmic tumour centre.

An account is given of the clinician's experience of an ophthalmic tumour centre established in an institute of ophthalmic pathology serving the whole of Denmark (population 5 mill). The Tumour Centre performs supplementary preoperative examination of patients, and gives advice with respect to biopsy, attempted total extirpation, enucleation or observation. The activities of the tumour centre have proved extremely valuable as it contributes to establishing more general lines concerning biopsy, attempted total extirpation, observation, or enucleation, to the benefit of patients as well as research. It is a presupposition that the advisory activity is carried out as an intimate collaboration between ophthalmic pathology and clinical ophthalmology.

Evaluation Studies as Topic↗
PubMed1974

Prostaglandin F2alpha and oxytocin compared with hypertonic saline and oxytocin for the induction of second trimester abortion.

Second trimester abortion was induced in a randomized investigation using a single dose of prostaglandin F2alpha (PGF2alpha) in combination with oxytocin in one group of patients, and hypertonic saline (20%) in combination with oxytocin in another group of patients. Oxytocin was administered in order to induce a rapid abortion, and was given intravenously in a glucose drip (100 I.U. oxytocin added to 1 litre of 5% glucose). Administration rate was 10 I.U./hour. The PG-group consisted of 16 patients. The mean induction-abortion interval for this group was 14.2 hours, and all patients aborted within 24 hours. In three cases the bleeding exceeded 200 ml. In one of these cases infection occurred. Only mild side effects occurred. The saline group also consisted of 16 patients. The mean induction-abortion interval in this group was 21.5 hours. Eleven patients aborted within 24 hours. In two cases the bleeding exceeded 200 ml. No side effects occurred. Intraamniotic instillation of PGF2alpha seems to be a good alternative to hypertonic saline for termination of second trimester pregnancies.

Abortion, Induced↗