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Biomedical subjects

E Grober

Publications and source records attributed to E Grober.

5 recordsLinked to original sources
PubMed1992

Skill learning and repetition priming in Alzheimer's disease.

While perceptual-motor learning occurs normally in Alzheimer's disease (AD) patients, their ability to acquire the skill of reading transformed text has not been well delineated. AD patients and matched controls were timed as they read two blocks of words presented in mirror image. Control subjects displayed both skill learning and repetition priming, whereas AD patients displayed only repetition priming. Skill learning in AD patients was associated with their ability to complete verbal analogies. They displayed the expected impairment in recognition for the words from the mirror reading task. The failure of AD patients to acquire the mirror reading skill can be understood through a task analysis and may reflect an underlying deficit in abstract reasoning that precludes the development of appropriate pattern analyzing strategies needed to transform rotated text.

Aged↗
PubMed1992

Implicit and explicit memory in young, old, and demented adults.

Previous study of scopolamine and memory (Grober et al., 1989) showed that young adults given moderate or high doses of scopolamine maintained maximum cued recall in spite of a dose-dependent decrement in free recall when memory was assessed by cued selective reminding (CSR), a procedure which circumvents inattention and induces semantic processing. Intact recall by CSR indicates either that scopolamine impairs memory indirectly through effects on attention and information processing or that it impairs explicit memory but not implicit memory. In the present study which was done to determine if CSR reflects explicit or implicit memory, a free association test was used to estimate implicit memory after CSR was administered; explicit memory was estimated with a final trial of cued recall. Data from young, nondemented, and demented adults indicate that CSR reflects explicit memory supporting the interpretation of the previous study that scopolamine does not produce direct impairment of explicit memory.

Adolescent↗
PubMed1991

Dual-task performance in demented and nondemented elderly.

The present study examined the ability of demented and nondemented elderly subjects to divide their attention between recalling digits and judging the similarity of pairs of letters. Both groups showed substantial decrements in digit recall following distraction by letter matching. To identify the nature of the interference effect, digit recall was scored according to a strict criterion where preservation of the serial order of the digits was required (order-based recall), and a lenient criterion where preservation of digit order was not required (order-free recall). While both groups showed a comparable decrement in order-based recall due to the interfering task, order-free recall virtually eliminated the decrement for the nondemented group whereas substantial interference was still observed in the demented group. These results suggest that letter matching interferes with digit recall in nondemented elderly primarily by disrupting order information. In the case of demented elderly, letter matching disrupts the preservation of item information as well.

Aged↗
PubMed1991

Development and validation of a model for estimating premorbid verbal intelligence in the elderly.

In a preliminary effort to improve the early diagnosis of dementia, we developed a regression-based method for estimating premorbid intelligence measured by the ability to read irregular words from the American version of the Nelson Adult Reading Test (AMNART). Using errors on the AMNART and years of education, a model for predicting current verbal intelligence (VIQ) was developed in a sample of nondemented elderly. Double cross validation showed that the model had high accuracy and stability in estimating current VIQ in nondemented subjects. The model was then used to estimate premorbid VIQ in mildly demented subjects. Estimated premorbid IQ exceeded current IQ by at least 10 points and did not differ from that of nondemented subjects. Less than 10% of nondemented elderly had discrepancies that were as large. If intellectual decline predicts future functional loss and can be reliably measured using cross-sectional data, the requirement of functional impairment may be an unnecessary barrier to the early diagnosis of dementia.

Actuarial Analysis↗