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Biomedical subjects

E Guest

Publications and source records attributed to E Guest.

2 recordsLinked to original sources

Novel methods for quantifying soft tissue changes after orthognathic surgery.

Laser scanners are becoming increasingly important as a tool for quantifying the outcome of facial surgery. However, few computer algorithms have been developed for this purpose. Researchers have either measured the differences in the positions of (manually located) landmarks, or have taken radial measurements of the distances between surfaces. Neither of these techniques provides satisfactory information about the shape changes between surfaces. In this paper, alternative methods are proposed and their performance is compared with that of the radial method. Tests on two patients show that the Correspondences by Sensitivity to Movement (CSM) and closest point algorithms provide the most realistic measurements of the differences between two surfaces. The CSM method was found to be useful for pinpointing areas where the shape has changed.

Adult↗

A three-dimensional model of the mouse at embryonic day 9.

This paper describes a digital, three-dimensional model of the mouse embryo at E9. The model was made by reconstruction from images of serial histological sections digitally warped to remove distortions and has a resolution of approximately 9 microns. The model can be digitally resectioned in any plane to provide images which resemble conventional histological sections. The main tissues have been identified and delineated by digital painting so that the anatomical components can be visualized and manipulated in 3-D surface- and volume-rendered views. This provides a three-dimensional definition of anatomy that will provide a useful tool for interpreting and understanding spatial data in mouse embryos. The anatomy of the model is discussed where it provides landmarks for interpretation and navigation or where it is unexpected in light of existing descriptions of the E9 mouse embryo. The complete anatomy is not presented in this paper but will be available on CD-ROM. A detailed description of the technical aspects of the construction of the model is included in an appendix. The model is the first of a series that will form the basis for an atlas/database of mouse development. This reconstruction and its associated anatomy are available in a variety of data formats with some supporting software from http:@genex.hgu.mrc.ac.uk/.

Anatomy, Cross-Sectional↗