Treating arthritis with nonsteroidals.
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Biomedical subjects
Publications and source records attributed to E Gurwich.
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A single-blind, prospective, crossover study of 27 ambulatory hypertensive outpatients was conducted to compare the antihypertensive effects of single daily dose versus multiple daily dose methyldopa regimens. Patients were randomly assigned to the two treatment modalities for a four-week study period. After four weeks patients were crossed over to the other study regimen. Each patient's blood pressure was determined three times daily, once each week. At the end of the study both treatment modalities were equally effective in controlling blood pressure levels. No serious adverse reactions were detected. This study has shown that patients currently on divided daily doses of methyldopa can be effectively treated on a single total dose of the medication.
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As the basis for a total quality assurance program, a hospital's pharmacy department developed minimum standards of practice and a compliance audit procedure.
A case of diffuse, erythematous, pruritic, maculopapular eruption which occurred on a limited, identical body surface with each administration of 2 different brands of lithium carbonate is reported. Clinicians should be aware of the possibility of this type of eruption occurring when prescribing lithium carbonate to patients.
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