An unusual case of haematuria treated by endoluminal repair.
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Biomedical subjects
E H Asham
Publications and source records attributed to E H Asham.
Endothelin-1 and tumour development.
There has been a growing conviction amongst oncologists that cancer is a disease characterized by changes in specific molecules. These changes include alteration in the structure, regulation or quantity of growth factors and their receptors, signal transducers and the proteins encoded by dominant or suppressor/recessive oncogenes. The role of endothelin (vasoactive peptide) in tumour cell signal transduction and mitogenesis and induction of endothelial cell growth and angiogenesis in tumour growth is discussed in this article.
Endothelin-1↗
Localized intraoperative cardiac tamponade.
A 65-year-old lady had undergone mitral and aortic valve replacement following an open mitral valvotomy and aortic valve exploration 5 years earlier. At reoperation, following sternotomy, extensive adhesions were encountered and it was decided to perform minimal dissection of the heart. Both the aortic and mitral valves were replaced using 23 mm and 29 mm St. Jude bileaflet valves, respectively. At the end of the procedure it was difficult to wean the patient off bypass as her mean arterial pressure dropped and the heart became dilated. It was found that a tamponade had developed, as a result of bleeding from the vent site in the pulmonary artery, and dissected a plane between the heart and the adherent pericardium. Her condition improved dramatically as the tamponade was released and she came off cardiopulmonary bypass with no inotropic support.
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