Cloning of subunits of the human colonic epithelial Na+ channel.
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Amino Acid Sequence↗
Biomedical subjects
E H Baker
Publications and source records attributed to E H Baker.
Informed consent for neuroleptics with elderly patients in two settings.
This paper presents the results of four studies that evaluated the use of neuroleptics in an aging population both in nursing homes and in a psychiatric teaching hospital. The purpose was to determine the degree to which prescribing practices were in compliance with recent court rulings respecting the right of patients to informed consent to "exceptional" medication. The results indicate that physicians in nursing homes do not inform their patients of the risks of neuroleptics, do not seek consent, and do not consider competency to be even an issue. Elderly patients in the acute academic setting were informed of risks and benefits. However, both consent to medication and the competency to give this consent were presumed until or unless the patient failed to acquiesce. The degree to which these practices might be in potential conflict with state law, ignore the benefits of a negotiated doctor/patient partnership, and demonstrate one aspect of poor quality of care are discussed, and policy recommendations are made.
Aged↗
The structure and reliability of the Teacher Temperament Questionnaire.
The Teacher Temperament Questionnaire is a recently developed instrument designed for personality assessment with preschool and early school children. The present study employed a sample of 116 in order to study the reliability and structure of the TTQ. A principal-components analysis yielded four well-defined components, which were labeled Compliance, Extraversion, Interpersonal Affect, and Environmental Sensitivity. These results did not support the theoretical scales. The component patterns were well defined and stable across the two administrations of the inventory. Internal consistency and test-retest reliability coefficients were determined for each of the four new scales. A second administration involving only items from the first three components provided a partial replication.
Child↗
Cotransformation of temperature sensitivity and nutritional markers in Neisseria gonorrhoeae.
Cotransformation remains the only tool for establishing linkage in Neisseria gonorrhoeae. Because of the difficulty of inducing auxotrophic markers via mutagenesis in this species, most previous studies have utilized antibiotic resistance and naturally occurring (auxotypic) auxotrophic markers. We have succeeded in isolating auxotrophic and temperature-sensitive mutants. The temperature-sensitive mutants have been characterized by their growth on complex and defined media at 31, 37, and 40 degrees C. Two of the mutants exhibited an unusual pattern of temperature sensitivity--growth on the defined medium but absence of growth on the complex medium at 37 degrees C. Both mutants, however, were temperature-sensitive on the two media at 40 degrees C. We have demonstrated linkages between markers isolated in our laboratory and the auxotypic markers of the clinical isolate RUG208. Ts-2 exhibited 85 to 95% linkage to Arg- and his-2 exhibited 40% linkage to Val-. In addition weak linkages were shown between his-2 and Arg- (2 to 6%) and between Arg- and Val- (3 to 5%). Linkages among his-2, Arg-, and Val- which could be demonstrated when deoxyribonucleic acid from strain F62 was used to transform RUG208 were absent when F62 was used as recipient for RUG208 DNA. Our data are consistent with a tentative map order of his-2, Val-, Arg-, Ts-2.
Amino Acids↗