Biomedical subjects
E H DAVIDSON
Publications and source records attributed to E H DAVIDSON.
DIFFERENTIATION IN MONOLAYER TISSUE CULTURE CELLS.
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INSTRUMENTAL ESCAPE CONDITIONING IN A WATER TANK: EFFECTS OF VARIATIONS IN DRIVE STIMULUS INTENSITY AND REINFORCEMENT MAGNITUDE.
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THE BEHAVIOURAL EFFECTS OF CHANGES IN ENVIRONMENTAL COMPLEXITY.
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ON THE RNA SYNTHESIZED DURING THE LAMPBRUSH PHASE OF AMPHIBIAN OOEGENESIS.
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Gene expression in differentiated cells.
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Heritability and control of differentiated function in cultured cells.
An established tissue culture cell line which retains a differentiated function in vitro is described. The cell line is of connective tissue origin, and its characteristic property is the synthesis and secretion of acid mucopolysaccharides, mainly hyaluronic acid. This differentiated cell function, the activity of which depends on continuous gene action, was found to be possessed by each of eleven clonal substrains, and is therefore a genetically heritable cell character. Rate of acid mucopolysaccharide biosynthesis falls sharply under the influence of the environmental conditions existing in crowded cultures, and this rate also declines if protein synthesis is directly inhibited with puromycin. Environmental modification of a differentiated product of gene action is thus illustrated in this study.
Effect of subcellular fractions of ascites tumor cells on tumor-host relationship in mice.
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