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Biomedical subjects

E H Knobler

Publications and source records attributed to E H Knobler.

5 recordsLinked to original sources
PubMed1990

Acute myelomonocytic leukemia presenting as a benign-appearing cutaneous eruption.

Aleukemic leukemia cutis is a rare condition in which patients have skin lesions containing leukemic cells before evidence of leukemia can be detected in the peripheral blood. There are only 23 cases of this phenomenon documented in the English literature. We describe a 62-year-old woman who developed a diffuse, clinically benign-appearing cutaneous eruption, which histologically showed an atypical infiltrate of cells, 4 months before leukemic cells were found in her peripheral blood and the diagnosis of acute myelomonocytic leukemia was made by bone marrow aspiration. This case illustrates the difficulty in diagnosing leukemia cutis from examination of routine histologic sections and the importance of specialized marker studies in determining the cause of an atypical cellular infiltrate of the skin. It also illustrates how leukemia cutis can masquerade as a clinically benign-appearing cutaneous eruption in a seemingly healthy patient with normal blood parameters.

Antineoplastic Agents↗
PubMed1989

Multiple minute palmar-plantar digitate hyperkeratoses.

Digitate hyperkeratoses are rare lesions of unknown cause. We wish to add a new variant of this entity to the few reports in the literature. Our patient is a 79-year-old woman with palmar pits and digitate hyperkeratoses limited to her palms and soles.

Aged↗
PubMedDate not supplied

Unique vascular skin lesions associated with human immunodeficiency virus.

We report four patients with antibodies to human immunodeficiency virus and/or acquired immunodeficiency syndrome who were noted to have unique vascular lesions that clinically resembled Kaposi's sarcoma or pyogenic granulomas. The lesions were asymptomatic erythematous-violaceous papules and nodules. They erupted over several weeks, without predilection for a specific cutaneous site. Most lesions resolved spontaneously. Histologically these lesions revealed a proliferation of vascular spaces lined by plump, cuboidal endothelial cells embedded in an edematous stroma with an inflammatory infiltrate. It is unclear if these lesions represent Kaposi's sarcoma or pyogenic granulomas or if they are distinct neoplasms associated with human immunodeficiency virus.

Acquired Immunodeficiency Syndrome↗