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Biomedical subjects

E H Oppenheimer

Publications and source records attributed to E H Oppenheimer.

At least 19 recordsLinked to original sources
PubMed1982

Fetal gonorrhea with deep tissue infection occurring in utero.

An unusual case of gonorrhea in utero is reported. The 30-week-old fetus died in utero at least four hours prior to delivery. Infection, therefore, occurred by aspiration of infected amniotic contents rather than by the more common route of passage through an infected birth canal. The infection resulted in deep-seated fetal tissue inflammation. Neissseria gonorrhoeae was cultured from maternal and fetal tissues and Gram-negative diplococci were stained in microscopic sections.

Adolescent↗
PubMed1981

Similarity of the tracheobronchial mucous glands and epithelium in infants with and without cystic fibrosis.

A retrospective study of 90 infants and young children with cystic fibrosis and 90 age matched controls without cystic fibrosis revealed no essential histologic differences in their tracheobronchial mucous gland reactions with and without pulmonary infection. Although the secretory response to specific stimuli (especially Pseudomonas or staphylococcal infection) varied in individual cases, every change seen in cystic fibrosis was present in the controls. Inactive or normally active mucous glands were usually present in the cystic fibrosis and control infants in the absence of infection. Moderate mucous gland activity in the absence of overt infection was not pathognomonic of cystic fibrosis; it was seen in both groups in response to an irritative stimulus, such as aspirated blood or gastric contents. Mucous gland secretions contained both acid and neutral mucins in the presence of infection, with no real distinction between the cystic fibrosis infants and controls, differing from the predominantly acid mucins in infected polyps of older children. Reparative squamous metaplasia in the tracheobronchial tract occurred more frequently in infants with cystic fibrosis than in controls. Although cystic fibrosis did predispose to progressive pulmonary disease (bronchiolitis, bronchiectasis), similar lung lesions were found in other metabolic and chronic disorders.

Bacterial Infections↗
PubMed1979

Differential pathology of nasal polyps in cystic fibrosis and atopy.

Nineteen nasal polyps from 13 patients were examined histologically. Nine polyps from seven cystic fibrosis (CF) patients could be positively identified by a triad of observations: delicate, barely visible basement membrane of surface epithelium without submucosal hyalinization, lack of extensive infiltration of eosinophils (Giemsa stains), and a preponderance of acid mucin in glands and cysts of the polyp and in its surface mucous blanket (Alcian Blue-periodic acid-Schiff stains). Two polyps from two patients with CF and atopy showed the characteristic findings of CF without modification. Eight polyps from four atopic patients without CF were identified by the reverse triad of changes: extensive thickening of the epithelial basement membrane and its extension into the submucosa as an irregular hyaline membrane, high stromal eosinophil count, and mainly neutral mucin in mucous glands, cysts, and mucous blanket. Hyperplastic mucous glands, mucous cysts of variable sizes, focal metaplasia of surface epithelium, and acid mucin in goblet cells were considered nonspecific lesions.

Adolescent↗
PubMed1975

Hepatic changes in young infants with cystic fibrosis: possible relation to focal biliary cirrhosis.

Focal biliary cirrhosis is an uncommon finding in infants with cystic fibrosis, but it is present in more than a fifth of surviving children and adolescents. It was found at postmortem examination in only five of 47 infants with CF younger than 3 months, in five of 32 infants from 3 to 12 months, and in 18 of 67 children older than 1 year. In infants under 3 months, excessive mucus in intrahepatic bile ducts was seen in 11 necropsies; in 15 others there were only nonspecific periportal changes. Cholestasis was found in the livers of 18 of the 26 infants. Excessive mucus in the biliary tree was occasionally associated with periportal changes and cholestasis in older infants. The periportal changes, which are regarded as nonspecific, were never found in infants more than 1 year of age.

Age Factors↗