Biomedical subjects
Publications and source records attributed to E H Porter.
This paper discusses the statistical analysis of dose/cure experiments, developing the simplest possible theory in detail with special attention to experimental design and to the range of validity of the methods advocated. Explanations are aimed at the mathematics-tolerant, not at the mathematician.
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The data from a dilution assay can be used not only to form an estimate of the TD50 (or log TD50), but also to throw light on the transplantation kinetics of tumours. Transplantation "by single cells" is the simplest sort of kinetics, and some tumours, of which we have given two examples, will transplant by single cells. Other tumours consistently transplant with anomalous kinetics-i.e. non-single-cell. A sensitive statistical test for single-cell behaviour has been developed, and we give three examples of tumours that clearly fail the test. The mechanism by which these anomalous tumours depart from single-cell behaviour is unknown, but we suggest an approximate statistical analysis for their assay.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.