PubMed Health⌕ Search

Biomedical subjects

E Hénocq

Publications and source records attributed to E Hénocq.

At least 19 recordsLinked to original sources
PubMed1985

Calcium phosphate adjuvanted allergens.

Calcium phosphate has been used for many years as an adjuvant for vaccines. Results of field trials using calcium phosphate in several countries have been published and demonstrate high immunogenicity and the absence of untoward reactions. This paper presents preliminary results of studies on the use of calcium phosphate, instead of aluminum compounds, for preparing adsorbed allergens. These were performed with purified house dust, mite, and grass pollen extracts. Immunotherapy with house dust and mite extracts gave a high rate (70%) of satisfactory therapeutic results. Efficacy was compared with immunization carried out with fluid preparations under the same conditions. It was found that satisfactory results were of the same order, but elicited a higher number of injections. Immunotherapy with calcium phosphate adjuvanted allergens was also equal, as with aluminium adjuvanted allergens, according to published data. Good tolerance was noted for adsorbed grass pollen extracts, but clinical evaluation of results can only be reported after treatments during at least three seasons.

Adjuvants, Immunologic↗
PubMed1982

Staphylococcal and human dander IgE antibodies in superinfected atopic dermatitis.

Ten patients (Group 1) with Staphylococcus aureus superinfected atopic dermatitis (SAD) were compared with three control groups without SAD. One control group (Group 2) was comprised of ten atopic patients with total IgE levels of greater than 1000 u/ml, another control group, of six atopic patients (Group 3) with total IgE levels of less than 1000 u/ml and a third group, of ten non-atopics (Group 4), five of whom were infected with Staphylococcus aureus. Total and specific anti-staphylococcal IgE levels and anti-human dander IgE were high in Group 1. Specific IgE levels to S. aureus were slightly increased in some Group 2 patients but were normal (less than 7%) for Group 3. No specific IgE to human dander antigen was detected in either Group 2 or Group 3. In the non-atopic control group (Group 4), six out of ten patients had both low total, and specific IgE antibodies to both staphylococcal, and human dander antigens. Two had increased total IgE and specific anti-staphylococcal IgE antibodies, and two more with a severe, chronic infection, also had anti-staphylococcal IgE antibodies. In SAD patients, a good correlation was seen between cutaneous basophil hypersensitivity and high specific IgE antibodies against staphylococcal and human dander allergens. Delayed type hypersensitivity reactions to staphylococcal antigen were negative or poorly positive in the SAD group by comparison to controls. A paradoxical anaphylactic type of response to the offending bacterial agent in SAD patients, associated with 'auto-atopy' to human dander, is discussed.

Antibodies, Bacterial↗
PubMed1981

Cutaneous basophil hypersensitivity in atopic dermatitis.

The infiltration by basophils into delayed hypersensitivity skin test sites was examined in patients with atopic dermatitis, contact dermatitis and in normal healthy persons. Atopic dermatitis patients, with large amounts of IgE, injected intradermally with staphylococcal antigens showed reactions that were more transient and erythematous than those of normal persons. On histological examination there were numerous, degranulating basophils among the perivascular mononuclear cells. Normal persons, with small amounts of IgE showed typical mononuclear cell infiltration and few basophils. Patients with contact dermatitis, one with much IgE, responded to patch tests to potassium dichromate or to nickel sulphate by delayed type reactions, but on histology, two of the four patients showed a significant infiltration by basophils. It is considered that the erythematous response to the antigen in atopic dermatitis patients is related to the basophil infiltration.

Adult↗
PubMedDate not supplied

Calcium-phosphate-adjuvanted allergens: total and specific IgE levels before and after immunotherapy with house dust and Dermatophagoides pteronyssinus extracts.

Results of total and specific IgE levels before and after immunotherapy carried out with calcium-phosphate-adjuvanted house dust and mite allergens for 36 patients are reported here. Total and specific IgE levels were evaluated by radioimmunological methods based on the IgE/anti-IgE interaction. Total IgE levels were not significantly different before and after immunotherapy; most of the specific IgE levels remained on the same order. IgE levels after immunotherapy varied only slightly in most patients and were not correlated with therapeutic results. Advantages of calcium phosphate compared to aluminium compounds are reported.

Adjuvants, Immunologic↗