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Biomedical subjects

E Halberg

Publications and source records attributed to E Halberg.

59 records · Page 4Linked to original sources

Plexo-serial linear-nonlinear rhythmometry of blood pressure, pulse and motor activity by a couple in their sixties.

A Nippon-Colin (model BP-203X) instrument was used for longitudinal monitoring of systolic and diastolic blood pressure and pulse, at 10-min or other intervals for 26 days and for a shorter span, by a healthy woman, 60 years of age, and her husband, 61 years of age, both following their usual routine in an academic setting and at home. Due to the quasi-portable nature of the instrument, it was possible on most mornings to bring it from the home by car to the laboratory at the University and to return it to the home on most evenings, for about 2 months. The sturdy instrument withstood transportation and functioned flawlessly for the spans investigated. While the lack of true portability is definitely a handicap of the instrument which precludes it from use in sports and during ambulation, the circumstance that measurements during certain excessive activities away from a given site are not feasible can lead to a more standardized assessment of the blood pressure profile in subjects who pursue sedentary occupations. The procedures of linear-nonlinear rhythmometry applied to the data from the woman covering 26-day spans each and her husband covering 3 days, partly at 10-min and 3-min intervals, respectively, reveal the feasibility of quantifying parameters of circadian rhythmicity rather consistently. Spans as short as 48-h, invariably for the case of systolic blood pressure and usually for the case of diastolic blood pressure, though with lesser consistency for heart rate, sufficed to assess the circadian rhythmic component of this couple in their sixties and may constitute an individualized reference standard for blood pressure monitoring by the elderly with a view of assessing blood pressure rhythm alteration before it may become pathogenetic.

Blood Pressure↗

Circadian and circannual aspects of the complement cascade - new and old results, differing in specificity.

Single cosinor analyses of several elements in the complement cascade suggest the occurrence of circadian rhythms in this immunochemical system. Some earlier results, obtained with less specific methods and reported as properdin, on reanalysis also reveal circadian and circannual rhythms in the aspects of immunology represented. The topic of the complement cascade as a whole is briefly reviewed in the content of modern knowledge.

Adult↗

Circadian susceptibility rhythm of the rat to alloxan.

The susceptibility of rats to alloxan undergoes a circadin rhythm. The toxicity rhythm, presumably involving injury to liver, kidney and other sites, pancreatic beta-cells in particular, is demonstrated in pooled data from 370 mature inbred Fischer or Minnesota Sprague-Dawley rats of both sexes kept in light from 06(00) to 18(00) alternating with darkness, some with free access to Purina laboratory chow with tap water at all times and some other rats subjected to one of three starvation schedules: 1) a 28-h fast before an intravenous alloxan injection; 2) a 28-h fast, except for a 4-h ad libitum feeding before injection; 3) a 28-h fast, except for a 4-h pre-injection tube-feeding of Nutrament (Mead and Johnson, Evansville, Indiana), 1.5 ml/100 g body weight. Survival time data on an additional 200 inbred Fischer rats reveal, next, that susceptibility to alloxan increases as the starvation span is lengthened from 24 to 84 h. The shortening in survival time indicative of this susceptibility increase is nonlinear; a circadian rhythmic change in susceptibility to alloxan is seen as a statistically significant wave-form indicative of the basic (persisting) rhythm, of applied interest as well to students of experimental diabetes.

Alloxan↗

Circadian and circatrigintan rhythms in pulse, oral temperature and blood pressure of a clinically healthy Japanese woman.

The circadian and circatrigintan (menstrual) system of a healthy Japanese woman has been quantified by single cosinor analyses. The results obtained at only 2 frequencies are discussed against the background of prior chronobiologic information. The paper documents different acrophase relations of rhythms with different frequencies in the same variables and includes a sketch of the position of the single cosinor method as a tool in a methodologic armamentarium of broader interest in anthropology, medicine and more generally in biology.

Adult↗