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Biomedical subjects

E Haufe

Publications and source records attributed to E Haufe.

3 recordsLinked to original sources
PubMed2001

Occupational medicine--its contribution to protection and promotion of health at work.

This article deals with the special demands on occupational medicine due to the changes of work and of tasks at workplaces. Conclusions for research in occupational medicine are drawn from these processes. They are discussed on the basis on an analysis of literature from the years 1980-1998. Focus of future research in the field of occupational medicine is developed by taking international tendencies, the interdisciplinary setting of occupational medicine, and the close relations between science and practice into consideration.

Health Promotion↗
PubMed1999

[Not Available].

Explore the source record for details and available documents.

Germany↗
PubMed1996

[Antibacterial action of clindamycin in chronic, recurrent tonsillitis].

After oral administration of 300 mg Sobelin, the efficacy and pharmacological kinetics of clindamycin (CAS 18323-44-9) were analysed in 35 patients with recurrent tonsillitis. Minimal inhibitor concentration (MIC) and minimal bactericidal concentration (MBC) have been evaluated for 120 strains. MIC and MBC for 91.7% of the strains amounted to 0.25 micrograms/ml. Concentrations of antibiotics in the serum were higher than 0.25 micrograms/ml after 12 h, i.e. higher than the minimal inhibitory concentration. The established free and efficient portion of clindamycin in the serum which is not bound to plasma proteins shows that a clear bacteriostatic effect is achieved up to 6 h after application of the antibiotic. The concentration in the tissue of the tonsils was 0.6-0.8 micrograms/g after 7-9 h indicating that sufficient MIC values were achieved. The free portion of the antibiotic in the tissues after 9 h also reached the MIC of germs. Hence clindamycin is considered to be an efficient antibiotic in the management of acute exacerbation of recurrent tonsillitis. Due to serum- and tissue levels of the tonsils administration of 300 mg of the test drug is indicated three times daily.

Adult↗