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E Hawkins

Publications and source records attributed to E Hawkins.

60 records · Page 4Linked to original sources
PubMedDate not supplied

Pathology of the kidney in childhood immunodeficiency: AIDS-related nephropathy is not unique.

Clinical and nephropathologic findings in autopsy material from 7 children with acquired immune deficiency syndrome (AIDS), 13 with severe combined immune deficiency (SCID), and 6 with a variety of other congenital immune deficiencies were reviewed in an effort to understand better the pathophysiology of the AIDS-related nephropathy. Non-HIV viral infection seemed to be associated with the development of the pathologic changes considered to be components of the AIDS-related nephropathy, and these changes, including focal segmental glomerulosclerosis (FSGS) and tubular epithelial cell injury and ectasia, were not limited to the kidneys of children with AIDS but were present in many of the congenital immune deficiencies. Of the 5 children with congenital AIDS, only the 3 who survived longer than a year developed AIDS-related nephropathy, whereas the two children with transfusion-acquired AIDS did not develop renal disease despite surviving for several years after initial infection.

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

Cytogenetic analysis of childhood endodermal sinus tumors: a Pediatric Oncology Group study.

Most adult germ cell tumors have a consistent cytogenetic abnormality, i(12p), and are aneuploid. Many pediatric germ cell tumors are biologically distinct from their adult counterparts, particularly endodermal sinus tumors (ESTs) of young children. We report cytogenetic and ploidy analysis of nine ESTs involving children under 3 years of age (four extragonadal and five testicular). Structural abnormalities were present in seven tumors and were identifiable in six: 5/6 had a structural abnormality of chromosome 1, usually terminal deletion of 1p; 5/6 showed 6q deletion; 3/6 had structural abnormalities of 3p; 2/6 showed abnormalities of chromosome 2. None showed an i(12p) or abnormality of chromosome 12. Ploidy analysis of the tumors correlated with the cytogenetic analysis; in particular, the tumor that was cytogenetically normal showed no aneuploid peaks. To determine if a marker chromosome was derived from chromosome 12 or if karyotypically normal cases included nondividing tumor cells, interphase fluorescence in situ hybridization using an alpha satellite probe for chromosome 12 was performed. These studies showed no evidence of an i(12p). We conclude that ESTs in young children show cytogenetic differences from their adult counterparts and that loci on 1p, 6q, and 3q need to be further studied.

Child, Preschool↗
PubMedDate not supplied

Perioperative management of adrenal cortical suppression.

Two questions asked prior to podiatric surgery for patients with a history of steroid therapy are: what are the risks involved with surgery and what specific measures should be taken in perioperative management for these patients? Studies identifying normal adrenal response to surgery in patients with a long-term history of steroid use have been noted. This paper discusses use of the metyrapone test to identify patients with adrenal suppression who may require additional steroid coverage perioperatively and empirical steroid dosing regimens.

Adrenal Cortex↗