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Biomedical subjects

E Hempel

Publications and source records attributed to E Hempel.

At least 37 records · Page 2Linked to original sources
PubMed1979

[Experience with the anti-androgen cyproterone acetate in the management of hirsutism].

Use of the antiandrogen cyproterone acetate in the treatment of hirsutism.--25 women with hirsutism or hypertrichosis faciei were subject to a "reverse sequential therapy" with cyproterone acetate (Hammerstein's regimen) for 1 to 3 years. In 8 patients, a limited, in 14 patients a satisfactory and in one woman a good result could be recorded. Cycle irregularities and subjective side effects were within a tolerable range. Studies of the hair pattern in 15 patients revealed a higher telogen rate as well as increased diameters of the hair stalks, compared with controls, in the temporal region of the head. These alterations disappeared in the course of the treatment. In the parietal region of the head no significant differences of the hair pattern were found in comparison with the controls and during application of the steroids.

Cyproterone↗
PubMed1979

[Examination of hormonal contraceptives by enzyme induction (author's transl)].

The influence of drug stimulated biotransformation on the biological effectiveness of two different contraceptives (Deposition and Gravistat) was observed.--Phenobarbital, a potent enzyme inducer, is known to increase the metabolism of steroid hormones, including estrogens and progrestogens. -- The clinical symptoms of drug mediated enzyme induction of hormonal steroid contraceptives are dysfunctional bleedings. This phenomenon is discussed.

Adult↗
PubMed1979

[A prospective trial on osteoporosis following bilateral ovariectomy with and without oestrogen replacement (author's transl)].

During four years a prospective study was carried out on 59 women, who had ovariectomized bilaterally for non-malignant diseases. It was studied the loss of the body length, the loss of bone mineral content in a middle phalanx expressed as percentage and several x-ray criteria. By means of combined performance signs of a beginning osteoporosis were found in 59 per cent of women after 2 years and in 68 per cent after 4 years after ovariectomy. -- The authors recommend relative simple screening methods: observation of body length, the dual beam x-ray spectrophotometry (Krokowski) and the minimal combined cortex thickness of the proximal radius according Meema. Women undergoing ovariectomy before the menopause should be attended by medical teamwork. The results of oestrogen prophylaxis were not so convincing as other investigators described.

Adult↗
PubMed1978

[Experimental studies on the castration osteoporosis in the rat. II. Behavior of bone minerals].

In Wistar rats the bone mineral content of calcium magnesium, phosphor, sodium and potassium was investigated 10 months after complete ovarectomy. 20 of ovarectomized animals obtained in this time 0,65 mg ethinyloestradiolsulfonate/kg/month orally. The ovarectomy decreased significantly the content of calcium and magnesium of femur, humerus, vertebra thoracis and lumbalis. After therapy with the oestrogen these minerals were increased, but not significantly. These results did not correlate with the degree of histomorphometrically established osteoporosis. Phosphor, sodium and potassium were not changed significantly. The role of oestrogen dosis was discussed.

Animals↗
PubMed1977

[Experimental allergic chorioretinitis. Appearance and behavior of complement-fixing anti-ROS antibodies in the sera following immunization with retinal antigens (author's transl)].

The authors studied the appearance and behavior of complement-fixing anti-ROS antibodies in the sera of GrCh rabbits following one or two intracutaneous injections of retinal antigens emulsified in Freund's complete adjuvant (KFA). Fourteen different antigenic preparations from heterologous, homologous, and autologous retinal components incorporated in KFA were tested and compared. Apart from the supernatant of a centrifuged homogenized preparation of homologous retina, all immunogens generally induced anti-ROS antibodies. The antibody titers (reciprocal values) reached a maximum 4 to 8 weeks post injection, at only low levels. The changes in antibody concentrations showed some relationship to the quality and dose of the immunogens. Anamnestic effects following reinjection reached maximum values within as little as 5 to 14 days. Animals not developing chorioretinitic lesions showed higher antibody titers more frequently than rabbits with clinically confirmed disease. Provided there is sufficient relevance of the humoral reactions observed, the complement-fixing antibodies we found in our experiments are more likely to have protective than pathogenic functions.

Animals↗
PubMed1977

[Structure and ultrastructure of the endometrium with the depot contraceptive Depositon].

Endometrium was investigated histologically in 55 fertile women and by electron-microscope in 6 women under the influence of Deposiston (Jenapharm), a sequential contraceptive containing a long acting oestrogen--ethinyloestradiolsulfonate. The drug was administered orally in 1 mg doses on the 5., 12. and 19. day of each cycle. To achieve proper withdrawal bleeding a single oral dose of 10 mg norethisteronacetate was given on the 26. day of the cycle. Whereas Sequenz- Ovosiston (Jenapharm), a "classical" sequential preparation causes only insignificant variations from the physiological endometrium of fertile women, Deposiston developes irregularly proliferated patterns in more than 50% of the patients, due to differences of the elimination rate of ethinyloestradiolsulfonate. The degree of proliferation covers a wide range from a slightly proliferated endometrium to changes similar to hyperplasia of the endometrium with cystically enlarged glands. The secretory transformation takes place 2 or 3 days following the progestogen application. In 2 of the cases a secretory pattern could be found several days before the intake of the progestogen. This indicates break-through-ovulations.

Adult↗
PubMed1977

[Determination and assessment of the estrogen proliferation dosage on the human endometrium].

The term, 'proliferation dosage' of an estrogen is defined differently in the gynecologic literature. In this article the authors were concerned critically with the methods of its determination. They came to the conclusion that under standardized conditions sufficiently sure and reproducible results can be received in postmenopausal women. 7 short acting and 3 long acting estrogens, some of which are clinically unknown substances, were examined using the following definition of proliferation dosage: 'Proliferation dosage is the amount of an estrogen which induces the signs of the late proliferation phase after being administered daily in the course of 10 to 14 days to postmenopausal women with atrophic endometrium.' In order to investigate the proliferating properties of 3 depot estrogens a modified test procedure was performed, derived from animal experiments' results and the planned clinical mode of application.

Age Factors↗
PubMed1977

[Comparison of vaginal cytologic effects and blood elimination curves of different oestrogen drugs (author's transl)].

With different oral oestrogens it was studied, if relations are existing between pharmacokinetic and vaginal effect. By means of Karyopycnotic Index and Dynamic Oestrogenicity Index the cytological effect was quantified from a single dose of oestradiol valerianate, mestranol, ethinyloestradiol and 3 depot oestrogens proved on postmenopause women and compared with adequate pharmacocinetical investigations. The courses of oestrogen levels did not correlate with indices. Both methods of investigation do not compensate, but complete one another. Depotoestrogens and short acting oestrogens are distinguishable with regard to proliferation maxium and steepness of index decline.

Delayed-Action Preparations↗
PubMed1976

Drug stimulated biotransformation of hormonal steroid contraceptives: clinical implications.

On the basis of well documented biochemical and pharmacological data about the influence of drug mediated enzyme induction on the biotransformation of natural and synthetic sex steroids, practical consequences for hormonal steroid contraception are described and discussed. Clinical reports dealing with this problem are still sparse. The clinical symptoms of drug stimulated biotransformation of hormonal steroid contraceptives are characteristic. Spotting or breakthrough bleeding are observed and in the extreme case conception may occur despite the regular intake of the contraceptive. The appearance of these symptoms differs from one individual to another. With a strong enzyme inducer, bleeding disorders can be provoked artifically in 50 to 60% of the women receiving hormonal contraceptive treatment. The range of drugs which stimulate biotransformation of hormonal contraceptives with consequent loss of their biological effectiveness is not completely known. For practical purposes, it is recommended that bleeding disturbances under hormonal steroid contraception in a previously regular cycle be regarded as loss of reliability; they should be remedied and taken as a sign to search for uncontrolled drug taking.

Ampicillin↗
PubMed1976

[Electron microscopic study on the proliferation and regression of the human endometrium following administration of a new depot estrogen ethinyl estradiol sulfonate].

The ultrastructure of endometrium was investigated after oral application of 1 or 3 mg of the new depot oestrogen etinyloestradiolsulfonate by means of long time observation with biopsies on postmenopause women. Details of this experimental proliferation was described. The highest functional activity in the endometrial gland and stromal cells was found 3 weeks after intake. There was no difference between ultrastructure following exogenous and endogenous oestrogen action. Degenerative changes within mitochondria were observed earlier than the regression in light microscopical picture.

Delayed-Action Preparations↗
PubMed1976

[Ultrastructural studies on the permeability of the amnion-epithelium for peroxidase and ferritin. Contribution on paraplacental metabolism].

By means tracer substances (horseradish peroxidase, ferritin) the permeability of human amnion and umbilical cord (2. to 6. lunar month) has been investigated ultrastructurally. The structure of intercellular cleft permits a passiv transfer of the water and electrolytes in both ways. The findings indicated, that the passage of proteins with a molecular weight of peroxidase predominantly takes place through the intercellular clefts less by means of pinocytosis. Ferritin particles can not penetrate. The epithelium of umbilical cord seems to play no special role in protein and water transport. The results were discussed.

Amnion↗