Botox in dermatology.
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Botulinum Toxins, Type A↗
Biomedical subjects
E Hernandez-Perez
Publications and source records attributed to E Hernandez-Perez.
Gross and microscopic findings in patients undergoing microdermabrasion for facial rejuvenation.
BACKGROUND: Microdermabrasion (MDA) is a new procedure used for the treatment of cosmetic problems, particularly to combat photoaging and intrinsic aging. Though excellent clinical improvement has been well documented, histologic support is limited. OBJECTIVE: To determine if microscopic changes correlate with clinical improvement and to examine the depth of penetration compared to chemical peels. METHODS: Seven women were submitted to five MDA sessions at weekly intervals. Skin biopsies were performed in all of them, before and after the treatment. Clinical and photographic assessments were recorded weekly. Data concerning skin features, including oiliness, thickness, dilated pores, and general appearance, were all assessed. Microscopic improvement of changes associated with cutaneous aging in the epidermis and dermis where all assessed. For statistical analysis, a t-test for small samples was utilized. RESULTS: All the patients showed clinical and microscopic improvement in all of the parameters assessed. The t-test for small samples showed a P <.05. CONCLUSION: MDA is a good alternative for facial rejuvenation. Improvements in both clinical and microscopic parameters are readily demonstrable.
Adult↗
Oral isotretinoin as part of the treatment of cutaneous aging.
BACKGROUND: A number of drugs have been used to prevent aging changes. However, studies of oral isotretinoin, the commonly used acne drug, as an antiaging drug are lacking. OBJECTIVE: To determine improvement in cutaneous aging utilizing oral isotretinoin combined with different procedures of facial rejuvenation. METHODS: Sixty patients ranging in age from 35 to 65 years, in whom additional modalities of rejuvenation were also used, were randomly assigned to receive treatment with oral isotretinoin (10-20 mg three times a week for 2 months, group A). Their results were compared with 60 patients who had undergone the same surgical procedures but with no oral isotretinoin (group B). RESULTS: All patients treated with oral isotretinoin noted improvement in wrinkles, thickness and color of the skin, size of pores, skin elasticity, tone, and reduction in pigmented lesions and mottled hyperpigmentation. A statistically significant difference was found in the improvement of group A (Wilcoxon test <0.01). Using minimal amounts of this drug, the side effects were practically negligible. CONCLUSION: Utilizing various procedures with oral isotretinoin allowed us to improve the effects of cutaneous aging. Our results using isotretinoin in these cases have been satisfactory. We believe that this is one of the first reports of the use of oral isotretinoin in intrinsic and photoaged skin.
Administration, Oral↗
Phaeohyphomycosis in El Salvador caused by Exophiala spinifera.
We identified Exophiala spinifera as the causal agent in a case of subcutaneous phaeohyphomycosis in El Salvador. Identification was based on the morphology of the fungus in tissue and the microscopic features of the culture obtained from the biopsy material. This case is the first of this type to be documented from Central America.
Child↗
Dehydroemetine therapy for herpes zoster. A comparison with corticosteroids.
A study involving forty patients, all sixty years of age or over, compared the use of dehydroemetine in twenty and triamcinolone in twenty for the treatment of herpes zoster. Pretreatment evolution was less than ten days. Patients treated with dehydroemetine did not experience postherpetic neuralgia, and in fourteen pain completely disappeared at the end of only one series of treatment, which in four patients consisted of only three injections. Postherpetic neuralgia developed in only eight patients out of those treated with triamcinolone, and in four pain persisted for more than six months. The results of laboratory tests, including cardiovascular evaluation, remained normal with both drugs.
Aged↗
Treatment of chromomycosis.
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Chromoblastomycosis↗
A simple and cheap coagulator.
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Cautery↗