Renal and metabolic clearances of sulfamethoxazole in Mexican healthy subjects.
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Biomedical subjects
Publications and source records attributed to E Hong.
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This study shows an experimental model in vitro useful to evaluate vasoactivity of EHP. The findings are consistent with other author's reports, as to the potentiation capacity of different vascular responses with biologic fluids in women with EHAE. As far as we know, this is the first report mentioning the placenta as the origin site of this type of substances.
In rat hepatocytes, active phorbol esters inhibited the alpha 1-adrenergic stimulation of phosphatidylinositol labeling with the expected potency order: phorbol myristate acetate (PMA) greater than phorbol dibutyrate (PDB). In contrast, in rabbit aorta the alpha 1-adrenergic action was inhibited dose-dependently by PDB but not by PMA. Similarly PDB (but not PMA) induced a strong contraction in rabbit aorta. The phorbol ester-induced contraction developed slowly, was dose-dependent and independent of extracellular calcium. These effects of PDB in rabbit aorta were neither inhibited by the protein kinase inhibitor H-7 nor mimicked by the synthetic diacylglycerol, OAG. Our results raise some doubts on the mechanism(s) through which the actions of PDB take place in rabbit aorta.
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