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Biomedical subjects
Publications and source records attributed to E Huth.
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The antitumoral activity of specific strains of beta-hemolytic streptococci, group A, published by Okamoto and his group, could be confirmed also with an in vivo-method. An own strain (No. 1C) with good antitumoral effect was used in the ascites-retothelsarcoma of the mouse. This effect was strain-specific. A hypothetical anti-tumor-factor of the streptococci is assumed. First clinical results are described.
The experimental results of Okamoto and his group with the preparation PB-B-45 from a strain of beta-hemolytic streptococci, group A, could be confirmed. The in vitro-method they used gives good results in the screening for strains of streptococci, which have antitumoral activity. With an own strain (no. IC) a complete inhibition of the growth of an ascites-retothelsarcoma of the mouse could be achieved by this technique.
In the serum of 43 children the activities of proteinases and peptidases by mean of 41 substrates have been determined in order to get knowledge of overall activities and differentiation of lysosomal proteolytic enzymes. Proteinases, cathepsins A, B, C and D, aminopeptidases, carboxypeptidases, dipeptidases, tripeptidases and aminoacidarylamidases have been checked. The enzyme pattern of the serum of a collective of 15 healthy children or those without serious clinical signs is demonstrated, also the alterations and differentiations in the serum of children with leucemia, pneumonia, inflammatory diseases of the respiratory tract, other inflammatory diseases and common diseases. Leucyl-glycyl-glycyltripeptidase, glycyl-glycyl-glycyltripeptidase, a proteosterase, carboxypeptidase A, a neutrale proteinase and basic proteinase (cathepsin B) and cathepsin C are increased. A distinct elevation has been found only in children with leucemia and pneumonia.
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