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Biomedical subjects

E I Bogdanov

Publications and source records attributed to E I Bogdanov.

At least 19 recordsLinked to original sources
PubMed2006

The post-syrinx syndrome: stable central myelopathy and collapsed or absent syrinx.

Among 168 cases with neurologic findings of cervicothoracic syringomyelia and MRI findings of Chiari 1 malformation and/or underdevelopment of the posterior cranial fossa, 15 patients (9.1 %) had collapsed, flat syrinxes and 14 patients (8.3 %) did not have syrinxes. Both groups of patients had clinical findings of central myelopathy that had been stable for at least 3 years. Magnetic resonance imaging detected atrophy of the cervical spinal cord in both groups and spontaneous communications between the syrinx and the subarachnoid space in 3 patients of the group with collapsed syrinxes. Analysis of these results and review of the literature suggest that patients with clinical signs of syringomyelia and Chiari 1 malformation or underdeveloped posterior fossa, but with small or absent syringomyelitic cavities, have the "postsyrinx" state as a result of spontaneous collapse of distended syrinxes.

Adult↗
PubMed2004

Clinical and neuroimaging features of "idiopathic" syringomyelia.

In some adult patients with cervical syringomyelia, MRI studies do not identify primary disease within the foramen magnum or spinal canal. To identify the etiology of this idiopathic type of syringomyelia, clinical features and posterior fossa (PF) measurements from 17 of these patients, 17 patients with Chiari I-type syringomyelia, and 32 control subjects were compared. Idiopathic syringomyelia and Chiari I-type syringomyelia manifested central cervical myelopathy and a small PF with narrow CSF spaces, suggesting that they develop by the same mechanism.

Adult↗
PubMed2002

Syrinx size and duration of symptoms predict the pace of progressive myelopathy: retrospective analysis of 103 unoperated cases with craniocervical junction malformations and syringomyelia.

OBJECTIVE: the clinical course of syringomyelia associated with craniocervical junction abnormalities is variable. About half of the unoperated patients have benign course. This is difficult to explain on the basis of the present pathogenetic theories. Therefore, to understand the mechanism of syrinx progression better, we studied the value of syrinx size, syrinx morphology, and the syrinx/spinal cord size ratio in predicting the rate of progression and the severity of myelopathy in these patients. METHODS: 103 adult patients with syringomyelia associated with Chiari 1 malformation and/or radiographic signs of underdeveloped posterior cranial fossa were clinically and MRI examined. Patients were subdivided according to the type of disease progression. Severity of neurological deficits, and MRI features (the extent of cerebellar tonsillar displacement, anteroposterior diameter of cavities, the spinal cord and cyst/cord ratio and the shape of cavities) were measured. RESULTS: a significant relationship was found between the mid-sagittal diameter of the syrinxes and the type of disease course; patients with short duration and rapid progression had the largest diameters of cavities, whereas patients with longer duration as well as with slow rate of progression had smaller diameters (chi(2)=28.90, P<0.05; chi(2)=29.89, P<0.01; r=-0.24, P<0.05). In addition, a correlation was found between the anteroposterior diameter of the spinal cord and cyst/cord ratio and the disease duration (r=0.52, P<0.05 and r=0.48, P<0.05, respectively). CONCLUSIONS: the initial years for the development of symptomatic syringomyelia associated with CCJ malformations are characterized by relatively rapid clinical progression accompanied with distended cavities. In the later periods of unoperated syringomyelia, some patients show delay in the progress of syrinxes accompanied with collapse of cavities, probably either due to a spontaneous formation of drainage between the syrinx and the subarachnoidal space, or due to the restoration of abnormal CSF dynamics at the CCJ level.

Adult↗
PubMed2002

[Clinical and neuro-visual study of syringomyelia].

One hundred fifty one patients with syringomyelia of different duration were studied using magnetic resonance imaging (MRI). An association between syringomyilia cavitation and Arnold--Chiari malformation as well as cerebellar tonsils location was found. No definite relationship between syringomyelia course and degree of cerebellum ectopia was detected. With disease duration increasing, cross dimensions of spinal cord cavitation are getting smaller. This may be due to spontaneous cavitations collapse. The hypothesis is supported by flattened out cavitation phenomenon found by MRI on the axial spinal cord sections of 39 patients. Such deformation corresponds to spinal cord atrophy developing during long-term disease course.

Adult↗
PubMed2000

Spontaneous drainage in syringomyelia: magnetic resonance imaging findings.

We present five cases of syringomyelia associated with Chiari I or other causes of partial obstructions at the cervicomedullary junction, with spontaneous disruption of the wall of a cervical syrinx and formation of a communication between the cavity and the subarachnoid space, shown on axial MRI. MRI can be used to investigate the hydrodynamics, showing the liquid inside the disrupted syrinx wall and the pathway of drainage. The finding of spontaneous drainage may be important for understanding the pathogenesis of syringomyelia and may be helpful for choosing a surgical approach.

Adult↗
PubMed1988

[Automatic analysis of the interference EMG of the brachioradial muscle in neuropathy of the radial nerve].

In 8 patients with radial neuropathy the authors studied histograms of distribution of potentials of motor units (PMU) by their duration, as well as of the number of intercrossings (T) and the mean amplitude of interference EMG of the musculus brachioradialis. The findings included a decrease in the T value and T/M ratio in the presence of an insignificant shift of the histograms and of the mean duration of PMU. With regard to the diagnosis of early neuropathies a reduction in the average value of T and T/M in the presence of ungraded voluntary tension of the muscle is diagnostically more important than changes in the duration of individual PMU.

Action Potentials↗
PubMed1988

[Contractile function of the anterior tibial muscle of man at different stages of the denervation-reinnervation process].

The contractile and electromyographic properties of the tibialis anterior muscle from the affected and normal side have been studied in 27 patients with lumbar radiculopathies. It was found, that at the early stages of denervation-reinnervation process (according B. M. Gecht e.a.) the rise of the strength and rate characteristics twitch contraction are determined. At the late stages this process having electromyographic signs of 'largeness' of the motor units showed the 'smallness' of the same characteristics.

Electromyography↗
PubMed1988

[Restoration of muscle contractile properties after partial and complete denervation].

The subject of this experimental study was the isometric contractile properties of rat tibialis anterior muscle, number and average size of the motor units as well as type content and type-grouping of muscle fibres according to SDH activity in the same muscle after total and partial denervation (crushing the sciatic nerve and L4). It has been shown that in the process of reinnervation after total and partial denervation, quantitative differences with the general tendency in the dynamics of restoration of contractile properties of the whole muscle are found at different dynamics of restoration of electromyographic and muscle histochemical characteristics of motor units.

Animals↗
PubMed1987

[Diagnosis of variants of neuropathies using the standardized methodology of quantitative analysis of the interference EMG].

In examining 36 patients with neuropathies the authors used standardized leads and a quantitative analysis of the interferential EMG and established the criteria for the differential diagnosis of radiculopathies, neuropathies in particular. Comparison with the findings of analysis of potentials of motor units showed that a "myopathic" shift revealed in some patients was due to stage characteristics of denervation and re-innervation process.

Adult↗
PubMed1987

[Muscle contractility after partial denervation (clinico-experimental study)].

Investigation of the contractility of the anterior tibial muscle in patients with vertebrogenic radiculopathy and in rats with experimental radiculopathy has demonstrated a reduction in the rate and force of isometric contraction. The method may be employed in the diagnosis and in the assessment of the dynamics and efficacy of therapy for neuromuscular syndromes.

Adult↗
PubMed1986

[Effect of thyroxine on skeletal muscles in hereditary myodystrophia].

The influence of 3-week L-thyroxin administration on contractility and histochemical composition of skeletal muscles was studied in 129Rj mice of normal and dystrophic genotypes. The rise in speed characteristics of isometric contraction and percentage of type II "fast" fibers was established in both types of animals. Contractile properties in dystrophic animals, receiving L-thyroxin, showed a tendency towards normalization and were comparable to those of normal animals.

Animals↗
PubMed1986

[Comparative properties and histochemical-type composition of skeletal muscles in various forms of experimental neuromuscular pathology].

The authors studied the characteristics of isometric contraction in in vivo experiments and the histochemical typical composition of muscles in different forms of experimental impairments of innervation simulating clinical pathology. The results demonstrate that in different forms of neuromuscular pathology there is a general tendency toward changes in the histochemical composition of muscles whereas alterations of contractile parameters of these muscles are fairly specific for each type of investigated disorder.

Adenosine Triphosphatases↗