[Human adrenoreactive systems of different types].
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Biomedical subjects
Publications and source records attributed to E I Chesmochakova.
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During the acute period of diverse forms of bronchial asthma in children the following alterations were detected in catecholamine metabolism and in various subtypes of the adrenoreactive system: an increase in urinary excretion of catecholamines, especially of adrenaline, as well as activation of catechol-O-methyl transferase; a decrease (or even absence) of beta 2-adrenoreactive system sensitivity, a decrease in beta 1-reactivity, while sensitivity of alpha 1-adrenoreactive system was increased (in the infectious-allergic form of the disease) and alpha 2-reactivity was unaltered. The uncoupling between catecholamines and various subtypes of the adrenoreactive system appears to occur during the acute period of bronchial asthma.
Distinct and generalized decrease in sensitivity of alpha 2-adrenoreactive system, pronounced decrease of beta 1- and beta 2-but not of alpha 1-adrenoreactivity were observed in children with acute rheumatic fever. After cupping of the rheumatic attack and restoration of circulation functions impairments of the alpha 2-adrenoreactivity (but not of beta 1- and beta 2-adrenoreactivities) were decreased however without complete normalization. Absence of a number of sympathogenic reactions appears to occur due to impairment of the adrenoreactive system sensitivity even though accumulation of catecholamines as found in biological fluids, as a result of which catecholamine-effector uncoupling elevated.
A new approach for evaluation of the sensitivity of alpha 2-adrenoreactive system in men, based on main effects of clonidine, is developed. It may be used in investigation of both physiological and pathological processes in human body.