PubMed Health⌕ Search

Biomedical subjects

E I Gulo

Publications and source records attributed to E I Gulo.

7 recordsLinked to original sources
PubMed2004

[Comparative clinical appraisal of the effectiveness and tolerability of paclitaxel-LANCE and taxol in combination chemotherapy for recurrences and platinum-refractory ovarian carcinoma].

A clinical appraisal of efficacy and tolerability of taxol (T) and a generic drug--paclitaxel--LANCE (P)--was carried out in two groups of patients with recurrences (9) or platinum-refractory ovarian carcinoma (17). In group I, patients aged 19-71 (mean age--47 yrs) had received 6-7 courses, while, in group II, patients aged 44-72 (mean age--52 yrs) who suffered tumor progression--15.0 courses of various chemotherapeutic regimens. Following standard premedication, T and P were injected 135 mg/sq., intravenously, dropwise, during 3 hrs, as a rule, either concurrently with platinum drugs or with hemzar. In the final analysis, there was no clinically significant difference in overall response--44-30% and 44-48%, respectively, nor any significant difference in side-effect incidence was reported.

Adult↗
PubMed1999

[The potential and feasibility of conservative therapy for the early stages of ovarian cancerĭ].

Improvement in techniques of early diagnosis of ovarian cancer (OC) has highlighted the importance of development of methods of conservative surgery. Numerous researchers have failed so far to reach consensus on working out strategies of treatment. A retrospective analysis of clinico-morphological data on 176 patients with bordar-line and OC stage I (conservative surgery--46; radical--130) (1980-1985) showed that efficacy depended on tumor pattern rather than method of treatment. Given high risk of recurrence in unremoved ovary (2 out of 28 reproductive females), bilateral salpingo-oophorectomy without removal of the uterus is discussed as an alternative procedure of conservative therapy. Modern procedures of this therapy requiring accurate staging and monitoring can be carried out at large medical centers only.

Adolescent↗
PubMed1998

["Second-look" surgery and diagnostic laparoscopy in the combined and comprehensive therapy of patients with ovarian cancer].

The data on 503 cases of ovarian malignancies were evaluated to work out indications for and clinical assessment of revision laparotomies. Second-look surgery was carried out in the following situations: (1) tumor elements found in the washings of the peritoneum in Douglas' space and high blood-serum levels of CA-125 (8 patients with stage I-II tumors, in clinical remission); (2) during remission, after 6-10 courses of polychemotherapy (13 patients with stage III-IV tumors); (3) during remission, after non-radical primary surgery (117); (4) suspected recurrence (144); (5) recurrence-free surgical pathology, e.g. ventral hernia, requiring laparotomy (22). Patients without repeated laparotomy (199) were in control. During remission, surveillance can be carried out using cytologic, ultrasound and immunoradiologic techniques since laparoscopy fails. The latter is useful, for diagnostic purposes, in case of discrepancy between clinical and ultrasound evidence as well as during monitoring in patients in clinical remission who show unfavorable levels of CA-125 and poor results of sonographic. Laparotomy is indicated prior to chemotherapy of inoperable tumors for morphologic verification of diagnosis. Indications for second-look operations can be significantly decreased considering the latest improvements in non-invasive monitoring technique. Laparoscopic examination can effectively serve the same purposes.

Adult↗
PubMed1997

[Lymphatic cysts arising after extended surgery for cervical and endometrial tumors].

Retroperitoneal lymphatic cysts account for 10.0-15.0% of complications of extended hysterectomy for tumors of the cervix uteri and endometrium. The data on 1,093 cases treated at the Institute Clinic in 1980-1994 have been analyzed to establish retroperitoneal lymphatic cyst frequency, factors of its development, criteria of diagnosis and procedures of therapy and prevention. Age over 50 years, low differentiation of tumor cells, deep invasion and considerable local extent of tumor have been identified as factors of risk for lymphatic dissemination. Ultrasonic examination proved the most effective diagnostic procedure with a credibility of 85.5%. Depending on cyst size and condition of adjacent organs, treatment of postsurgical lymphatic cysts may be palliative or radical. In the present study, surgery was used in 28.8% of cases. Frequency of complications can be lowered by timely detection of early forms of cancer of the cervix uteri and endometrium which do not require lymphadenectomy.

Adult↗
PubMed1992

[The indications for second-look laparotomy in ovarian cancer patients].

Data on 304 patients with ovarian malignancies (mostly epithelial-72.0%) who had undergone second-look surgery were analysed to develop indications and assess the clinical value of the procedure. Second-look operations were performed 10-22 months after primary surgery in the following clinical settings: (1) clinical remission if wash-offs from the Douglas' pouch peritoneum revealed tumor cells or a high blood-CA-125 level was established (8 patients with stage I-II cancer), (2) remission after 6-10 courses of combination chemotherapy (13 patients with stage III-IV tumor), (3) remission following non-radical primary surgery (117 cases), (4) patients with suspected relapse (144), and (5) cases who were not suspicious for relapse but required laparotomy for concomitant surgical pathology such as, for instance, ventral hernia (22). Intra- and postoperative complications were encountered in 29 out of 304 (9.5%) patients and operative lethality rate was 0.9%. It was shown that improvement in noninvasive methods of monitoring allows to limit indications for second-look surgery in stage III cancer.

Adenocarcinoma↗
PubMed1992

The controversial 'second-look' laparotomy.

To determine optimal indications for and clinical assessment of the significance of relaparotomy, the data of 304 women with malignant ovarian tumours (of epithelial origin, predominantly, 72%) who had undergone a 'second-look' operation were analysed. 'Second-look' relaparotomies were performed 10-22 months after the initial operation, on the following clinical indications: 1) clinical remission after initial combined treatment (surgery + chemotherapy) in cases where malignant cells are found at systematically performed cytological examinations of ??? or lavage from peritoneal surfaces of the Douglas cul-de-sac plus high levels of CA 125 in blood serum (8 patients with stages I and II, FIGO classification); 2) remission after adequate combined treatment and following 6-10 cycles of polychemotherapy, in order to decide whether to abandon or continue with treatment (13 patients with stages III and IV); 3) clinical remission following initial operation which was voluminously non-radical (117 patients); 4) suspicion of tumour recurrence after adequate combined treatment (114 patients); 5) no suspicion of cancer recurrence, though with ventral hernia or other pathology requiring relaparotomy (22 patients). Complications arising at the 'second-look' operation or during the postoperative period were observed in 29 of the 304 patients (9.5%), giving a postoperative mortality of 0.9%. According to experience, the positive significance of 'second-look' operations to optimize treatment of patients with malignant ovarian tumours is obvious.

Antineoplastic Combined Chemotherapy Protocols↗