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Biomedical subjects

E I Nikolaeva

Publications and source records attributed to E I Nikolaeva.

At least 19 recordsLinked to original sources
PubMed2001

[Experience in studying antigenic activity of inactivated hepatitis A vaccine].

The results obtained during the study of antigeneity of inactivated vaccines against hepatitis A ("Avaxim", France; "Hep-A-in-VAC", Russia; "Havrix", Belgium) used in troop units and RF MD institutions are presented in the article. The aim of the investigation is choice of the drug that provides the production of antibody protective levels in maximally short periods. It is very important for the army collectives sent to the zones of armed conflicts and HAV epidemic centres. It is shown that the most acceptable vaccine is "Avaxim" that provides the highest percentage of seroconversion (93.75%) with antibody level not less than 125 mIU/ml. It is recommended to consider this level as the protective one in conditions of army collectives.

Antibodies, Viral↗
PubMed1998

[Relationship of vascular reactivity to blood lipid spectrum and lipid peroxidation in unstable angina].

AIM: To examine the relationship between the vascular response of the microcirculatory bed to vasoactive agents and lipid peroxidation (LPO) and antioxidative defense in patients with unstable angina pectoris. MATERIALS AND METHODS: Thirty male patients (mean age 58.0 +/- 2.4 years) were examined. The patients were divided into 2 groups: 1) those with high alpha-cholesterolemia alone and 2) those with high alpha-cholesterolemia concurrent with hyperglyceridemia and elevated total cholesterol levels. Photoplethysmographic determination was used to evaluate vascular responses to norepinephrine (vasopressor function) and histamine (vasodilating function), the blood levels of cortisol, LPO products, antioxidative protection components, histamine, and serotonin. RESULTS: Vascular dilating function was found to be most pronounced in Group 1. Moreover, Group 1 patients had a significant depression of the antioxidative defense system and the highest blood levels of cortisol, and serotonin. The levels of LPO products did not differ significantly in both groups though they were significantly higher than those in healthy individuals. CONCLUSION: Impairment in the antioxidant system and in coordination of vasodilating function to histamine stimulation are typical of patients with unstable angina.

Angina, Unstable↗
PubMed1995

Relationships between left hemisphere predominance and disturbances of lipid metabolism in different ethnic groups.

The purpose of this study was to analyze the relationships between brain hemisphere predominance and disturbance of lipid metabolism in atherosclerosis in different ethnic groups. Three groups of subjects were examined: 52 healthy Selkups (the isolated ethnic population of the Far North), 50 healthy Russian men, living in Novosibirsk, and 78 Russian men, living in Novosibirsk, who had myocardial infarction before the age of 50. Blood cholesterol, low density lypoprotein (LDL) and high density lypoprotein (HDL) levels of the subjects with different brain functional asymmetry were compared. The lack of either hemisphere predominance is the most common among the Selkups. The population of Selkups as a whole showed low concentrations of cholesterol and LDL in comparison with both Russian groups. For all examined groups the pattern of lipid metabolism has been worsened for the subjects showing the left hemisphere predominance. The changes of lipid metabolism indices in subjects with the dominant left hemisphere is discussed.

Arctic Regions↗
PubMed1993

Prognosis of myocardial infarction and brain functional asymmetry.

Seventy-eight men (mean age, 47.0 +/- 1.1 years) who had suffered from myocardial infarction were examined. Blood cholesterol, lipoproteins, triglycerides, insulin and cortisol concentrations were compared in patients with left hemisphere or right hemisphere cerebral dominance. Patients with left hemisphere dominance had more serious disease and much higher levels of blood cholesterol and lipoproteins. Patients with right hemisphere dominance had the highest levels of blood cortisol and insulin. The brain's functional asymmetry may be one of the risk factors for coronary atherosclerosis in subjects under the age of 50 years.

Cholesterol↗
PubMed1992

[Functional sensory and motor asymmetry profile in patients with neuroses and those with diseases of the digestive system].

Functional sensorimotor asymmetry (FSMA) was analyzed in 21 healthy volunteers, 19 neurotic patients and 29 patients suffering from alimentary diseases. Among the neurotic patients, there prevailed those with the left profile of FSMA as compared to the group of healthy persons. As to the group of the patients with alimentary diseases, a subgroup of persons with no disturbances of emotional information perception by the neurotic type was distinguished according to the psychophysiological characteristics. Among those persons in the given representative sample, none showed the left and symmetric profiles of FSMA.

Adult↗
PubMed1991

[Analysis of the profiles of functional psychomotor asymmetry and mental stress in patients with cardiovascular diseases].

The profile of functional sensomotor asymmetry (FSMA) was evaluated by a series of tests and inversion of emotional reflection. Altogether 70 healthy subjects and 114 cardiovascular diseases patients were examined. Among the patients there were 36 subjects with acute myocardial infarction, 28 with coronary heart disease, 26 with borderline hypertension and 24 with neurocirculatory dystonia (NCD). The highest emotional tension was recognized in myocardial infarction and coronary heart disease. NCD patients exhibit the left FSMA profile more frequently than healthy subjects.

Adult↗
PubMed1990

[Weight gain during pregnancy in relation to somatic types of women].

The paper presents findings on weekly weight gain in pregnant women as related to constitutional make-ups. Normal and apparently normal pregnant women who were followed up at an antenatal clinic from 7-8 to 40-41 week's gestation have been assigned at the beginning of pregnancy to three weight groups: normal body weight, excessive body weight due to increased fat deposition and deficient body weight. Anthropometric measurements at 7-8, 25-26 and 36-37 weeks showed that weight gain and fat accretion were highest in pregnancies with an initial deficient body weight and lowest in pregnant women with adiposity. Correlation analysis suggested that there was a relationship between the maternal body weight, gestational weight gain and neonatal birthweights. Since women with initial deficient body weights have a wider range of weight gain, as compared with other somatic types, dietary restriction counselling should be cautious and adequate.

Anthropometry↗
PubMed1989

[Use of the emotional reflection inversion test for detection of persons with high risk of development of neurotic disorders].

The results of application of emotional reflection inversion test were juxtaposed to the data of psychiatric investigation of 133 subjects in an out-patient department. The test proved most efficient in detecting the neurotic responses ensuring emotional strain and nonadaptive attitudes. The test is simply used and recommended for mass prophylactic population screening.

Adult↗