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Biomedical subjects

E I Papilova

Publications and source records attributed to E I Papilova.

9 recordsLinked to original sources
PubMed1983

[Acute necrotic encephalitis in adults].

Twenty-five patients aged 15 to 68 years suffering from acute necrotic encephalitis were subjected to combined examination involving epidemiological, clinical, electroencephalographic, echoencephalographic, pathomorphological, virological, immunological, and computerized tomography studies. The results obtained showed both the distinctive characteristics of the pathogenesis of this disease (with vascular and allergic disorders being its constant feature) and a probable etiological role played by Type I herpes simplex virus and various respiratory viruses in more than half of the cases. Efficacy of pathogenetic therapy is shown. Further areas of research in the field of necrotic encephalitides are also discussed.

Acute Disease↗
PubMed1983

[Encephalitis related to influenza in adults].

The results of clinical, virological, and pathomorphological examinations of 25 patients with nervous system involvement into the morbid process caused by influenza infection are presented. The influenza-associated encephalitis is regarded as a manifestation of an infectious-allergic process, in the pathogenesis of which the vascular factor plays the leading role. Therapy with vasoactive drugs combined with glucocorticoids has appeared to be the most efficacious.

Adolescent↗
PubMedDate not supplied

[Toxicological study of the new antiviral agent, 5-bromuridine].

Toxicity of the new antiviral drug 5-bromuridine was studied in experiments on laboratory animals at systemic and local administration. The drug proved to be little toxic. Studies of acute toxicity of the drug administered systemically (intraperitoneally, intravenously and per os) showed it to be well tolerable by animals at concentrations 10-20 fold and 150-300 fold (with reference to an average weight of human body) exceeding the doses recommended for humans at local administration. As compared to controls no changes in the animals' state, peripheral blood and in its principal functional and biochemical parameters, in the activity of serum enzymes as well as in the microstructure of internal organ tissue were revealed during prolonged local administration of the drug to the animals under conditions similar to clinical ones but at higher concentrations and longer exposure.

Animals↗